1. THE WAR AGAINST CANCER
Presented by Sayer Ji, founder of GreenMedInfo.com

2. THE WAR AGAINST CANCER:
ENDLESS BY DESIGN?
“Only the dead have seen the end of war.”
― Plato
“All war is a symptom of man's failure as a
thinking animal.”
― John Steinbeck
Presented by Sayer Ji, founder of GreenMedInfo.com

3. Declaring War Against Cancer
 The signing of the National Cancer Act of 1971
by then U.S. President Richard Nixon is viewed as
the beginning of the war on cancer.
President Richard Nixon signs the
National Cancer Act, Dec. 23, 1971,
launching a $1.6 billion federal
crusade to conquer cancer. (AP)

4. Putting the War on Cancer Into Perspective
Causalities In The War On Cancer Causalities In The War On Terrorism
•1,569,670 estimated 17 U.S. citizens
new cases worldwide killed as a
•571,950 estimated
result of incidents of
terrorism: [in 2011]
deaths [in 2011]
Source: U.S. Dept. of
Source: ACS, Cancer State, 7.21.12
Facts & Figures

5. The War Against Cancer
 “Atoms for Peace”
 “Humanitarian” Applications
of weapons of mass
destruction
 Radiotherapy
 Chemotherapy
 Metaphoric of Fear

6. Nitrogen Mustard
Nitrogen mustards have both medical Schecdule 1 substance, Chemical Weapons
and chemical weapon designations: Convention – production over 100 grams per year
must be declared to the Organization for the
HN2 (Mechlorethamine, trade name Prohibition of Chemical Weapons
Mustargen): Bis(2-
chloroethyl)methylamine
HN3: Tris(2-chloroethyl)amine (still
used for military purposes)

7. Radiotherapy
"There is no safe dose of radiation“
~ Professor Edward P. Radford, Physician and
There are over 30 radioisotopes used Epidemiologist
in medicine, with common ones
including:
Fluorine-18, gallium-67,indium-111,
iodine-131, xenon-133,yttrium-90

8. 1.3 MILLION OVERDIAGNOSED AND OVERTREATED
FOR BREAST CANCER OVER THE PAST 30 YEARS.
*#1 Hidden Health Threat to Women Is Overdiagnosis
And Overtreatment, e.g. Breast Cancer, Osteoporosis, Menopause, Cholesterol Screening, etc.
Collateral Damage? Millions of Causalities in the War Against Cancer

9. The United States Preventive Services Task Force is an independent panel of experts in prevention and primary care appointed by the
Department of Health and Human Services. In 2011 it recommended that men no longer receive PSA screenings for prostate cancer.
“Unfortunately, the evidence now shows that this test does not save
men’s lives.” ~ Dr. Virginia Moyer, taskforce Chair

10. THE NEW BIOLOGY WILL ALLOW FOR THE
CONCEPT OF A NON-PROGRESSIVE, NON-
MALIGNANT CANCER
The Conventional Concept of Cancer is a “Meme” (thought-
form) with real malignancy.

11. Cancer Stem Cells
• CSCs are considered responsible for cancer recurrence,metastasis and
treatment resistance.
• Found in diverse tumors, e.g. brain, breast, colon, ovary, pancreas,
prostate , pancreas, melanoma, multiple myeloma
• Slow to divide
• Minority subpopulation (1:100 – 1:1000)
• Capable of self-renewal (theoretically infinite)
• De-differentiated
• Capable of giving rise to each, diverse cell phenotype in a tumor population
• Explains why chemotherapy and radiation fail to prevent recurrence and
may increase malignancy
• Capable of being induced via chemotherapy [Cell Cycle, 2012]
• Capable of being induced via radiation, e.g. breast, glioma [Stem Cells,
2012, Nature, 2006]

12. CSC Hierachy
Image Source: EuroStemCell
The tumor may not be the “enemy.”

13. Radiotherapy Failure – Cancer Stem Cells
“Radiation treatment generates therapy-
resistant cancer stem cells from less aggressive
breast cancer cells.” ~ Cancer [ACS], June 2012
“Radiation-induced reprogramming of breast
cells” ~ Stem Cells, May 2012
“Using non-BCSCs sorted from
patient samples, we found that
ionizing radiation reprogrammed
differentiated breast cancer cells
into induced BCSCs (iBCSCs).” ~
Stem Cells, May 2012

14. Cancer Tumors as Metazoa 1.0 –
tapping genes of ancient ancestors Paul Davies
Physical Biology (2011)
The genes of cellular cooperation that evolved with multicellularity about a billion years ago are the same genes that
malfunction to cause cancer. We hypothesize that cancer is an atavistic condition that occurs when genetic or epigenetic
malfunction unlocks an ancient 'toolkit' of pre-existing adaptations, re-establishing the dominance of an earlier layer of genes
that controlled loose-knit colonies of only partially differentiated cells, similar to tumors. The existence of such a toolkit implies
that the progress of the neoplasm in the host organism differs distinctively from normal Darwinian evolution. Comparative
genomics and the phylogeny of basal metazoans, opisthokonta and basal multicellular eukaryotes should help identify the
relevant genes and yield the order in which they evolved. This order will be a rough guide to the reverse order in which cancer
develops, as mutations disrupt the genes of cellular cooperation. Our proposal is consistent with current understanding of cancer
and explains the paradoxical rapidity with which cancer acquires a suite of mutually-supportive complex abilities. Finally we
make several predictions and suggest ways to test this model. NCBI

15. Cellular Immortality
“Single cells have but one imperative “If you look deeply into the palm of your hand,
– to replicate. They are, in effect,
immortal. But when cells first formed you will see your parents and all generations
co-operative assemblages, a new of your ancestors. All of them are alive in this
deal was struck. Most organisms moment. Each is present in your body.
outsourced their immortality to
specialised germ cells (eg sperm and You are the continuation of each of these people.”
ova), and in return accepted death Thich Nhat Hanh
for themselves. Thus a typical tissue
cell might reproduce a handful of
times and then die.” ~ Paul Davies

16. Turritopsis nutricula “immortal jellyfish”
Turritopsis nutricula, the immortal jellyfish, is a
hydrozoa whose medusa, or jelly fish, form can
revert to the polyp stage after becoming sexually
mature. It is the only known case of ametazoan
capable of reverting completely to a sexually
immature, colonial stage after having reached sexual
maturity as a solitary stage

17. Tumor Microenvironment or “soil”
Known contributors to stemness:
• Ethanol/breast cells [Cell Cycle, 2012]
• Cigarette smoke [Cell Cycle, 2103]
• Hypoxia/Oxidative Stress [Stem Cells, 2008]
• Radiation therapy exposure [Stem Cells, 2012]
Chemotherapy: Fluorouracil [Tumour Biology,
•
2013]  The microenvironment
•
•
Chemotherapy: Carboplatin [Cell Cycle, 2012]
Primary Tumor Surgery [Frontiers of
may be decide what
Bioescience, 2012] turns on or off the
“stemness” phenotype

18. Time Scale of Evolution
•First Eukaryotes evolved between 1.6-2.1 billion years ago.
•Rudimentary multicellular organisms evolved from unicellular eukaryotes at
least 1.7 billion years ago. [Metazoa 1.0]
•600 million years ago Earth experienced the Cambrian explosion (Big Bang of
Life), in part due to the Great Oxygenation Event. [Metazoa 2.0]

19. Oncogenes: Ancient Survival Genes
Unmasked?
•MYC Oncogene found deregulated in
30% of human cancers
•Traced back 600 million years in
ancestral metazoan, Hydra, particularly
within their stem cells.
Source: Science Daily, Feb. 15th, 2010
•"It is amazing that we have been able to find this oncogene in such a simple organism," says
Hydra expert Hobmayer from the Institute of Zoology.
•The stem cells in the fresh water polyp strongly indicate its regenerative ability -- the polyp
completely regenerates within five days and, thus, it could theoretically age ad infinitum.

20. Nocebo: Deadly Expectations
“Suicide and cardiovascular death after a cancer diagnosis.”
N Engl J Med. 2012 April
Researchers looked at data on more than 6 million Swedes aged 30 and older between 1991-2006
using the country’s health registries in order to determine how the psychological toll of cancer diagnosis
impacts the risk for death. After analyzing over 500,000 people who were diagnosed with cancer
during that period, the risk of suicide was found to be 12 times higher and the risk of heart-related
death 6 times higher during the first week following diagnosis versus those who were cancer free.

21. Adrenaline Feeds Cancer Malignancy
In a 2012 article published in the journal Cancer Genetics and Cytogenetics,
titled "Adrenaline induces chemoresistance in HT-29 colon
adenocarcinoma cells,” researchers found that the stress hormone
adrenaline induces multidrug resistance in colon cancer cells.
When adrenaline-induced P-glycoprotein levels increase within cancer cells,
they become more effective at excreting drugs that may do them harm, e.g. chemotherapy.

22. The Nutrigenomic Environment
The molecular fabric of our body is woven from
the body of the Earth – via what we ingest, inhale
or apply topically.
•Co-evolution of plants (Ordovician
period, 450 mya) and animals (Cambrian)
•The preCambrian “Age of Chemistry,”
600 mya to 4,700 mya versus today’s
“Age of Chemistry.”
•"Ascorbic acid induces growth inhibition and redifferentiation of human gastric cancer cells
through the production of hydrogen peroxide. “ ~ Biomed Environ Sci. 2006
•Turmeric is capable of altering the expression of a wide range of genes simultaneously ~
GreenmedInfo

23. Turmeric
PubMed.gov: 5,470 abstracts
GreenMedInfo.com: 1,585 abstracts
613 Diseases
175 Pharmacological Actions

24. Natural CSC-Targeting
Non-Toxic Natural Substances Which Target and Kill
CSCs
Natural compounds have been shown to exhibit three
properties which make them suitable alternatives to
conventional chemotherapy and radiotherapy:
High margin of safety: Relative to chemotherapy agents
such as 5-fluorouracil natural compounds are two orders
of magnitude safer
Selective Cytotoxicity: The ability to target only those cells
that are cancerous and not healthy cells
CSCs Targeting: The ability to target the cancer stem cells
within a tumor population.

25. Natural CSC-Targeting
Research indicates that the following compounds (along
with common dietary sources) have the ability to target
CSCs:
Curcumin (Turmeric)
Resveratrol (Red Wine; Japanese Knotweed)
Quercetin (Onion)
Sulforaphane (Brocolli sprouts)
Parthenolide (Butterbur)
Andrographalide (Andrographis)
Genistein (Cultured Soy; Coffee)
Piperine (Black Pepper)
Additional research found on the GreenMedInfo.com
Multidrug Resistance page indicate over 50 compounds
inhibit multidrug resistance cancers in experimental
models.

26. You Can Regress Cancer with Food!
Journal of Cancer
Epidemiology, Biomarkers & The study observed the
Prev., 2008 “Flaxseed “Proliferation rates were
supplementation (not dietary
fat restriction) reduces significantly lower (50% )
prostate cancer proliferation among men assigned to
rates in men presurgery.” the flaxseed arms. ”

27. You Can Regress Cancer With Food!
Journal of Clinical Cancer The study observed the “effects of
dietary flaxseed on tumor biological
Research, 2005 “Dietary markers and urinary lignan
flaxseed has the potential excretion in postmenopausal
to reduce tumor growth in patients with newly diagnosed
breast cancer. …an increase in
patients with breast apoptosis (30.7%; P = 0.007) were
cancer.” observed in the flaxseed, but not in
the placebo group.”

28. Tools for Self-Empowerment
PUBMED.GOV 22 million biomedical citations Internet – Mycellium – Global Brain

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