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fMRI Results
- 2. Harnessing the power and appeal of technology to improve kidsâ health 2!
- 3. Our Model! research! innovation! customer input! 3!
- 4. Re-Mission! â˘âŻ 20 levels! â˘âŻ 7 cancer types! â˘âŻ Objectives: kill cells, manage side-effects and complications! â˘âŻ Weapons: chemo, radiation, antibiotics, stool softener! 4!
- 5. PEDIATRICS August 2008! RE-MISSION WORKS! â˘âŻ Improved treatment adherence! â⯠16% increase in antibiotic doses! â⯠Blood chemo levels 20% higher! â˘âŻ Improved cancer knowledge! â˘âŻ Greater self-efďŹcacy: Increased belief in ability to control/cope with cancer! 5!
- 6. Identifying the mechanisms of action in Re-Mission! Knowledge and learning are only part of the story 6!
- 7. Identifying the mechanisms of action in Re-Mission! ? Treatment! adherence! 7 7!
- 8. Re-Mission Works â But How? Identifying the mechanisms of action in Re-Mission! Emotion/! Motivation! Treatment! adherence! Knowledge! Re-Mission Attitudes Study! Jennifer Aaker, Ph.D., Stanford University! 8 8!
- 9. Identifying the mechanisms of action in Re-Mission! How does videogame play inďŹuence real-life behavior?! ? Interactivity and Reward-Related Neural Activation During a Serious Videogame! ! h#p://dx.plos.org/10.1371/journal.pone.0033909  ! 9 9!
- 10. Identifying the mechanisms of action in Re-Mission! 10 min fMRI T2*! Rest! Rest  Rest  Rest  Rest  Rest  Rest  Play! Rest! 10!
- 11. Identifying the mechanisms of action in Re-Mission! Interactive play ! Passive exposure! Caudate! Caudate! Thalamus! Thalamus! Hippocampus! Hippocampus! 11 11!
- 12. iden%fying  mechanisms  of  ac%on  Identifying the mechanisms of action in Re-Mission! Results! â˘âŻ Game-based interventions can be powerful tools for activating health-supportive behaviors! â˘âŻ Psychological outcomes (knowledge, self-efďŹcacy)! â˘âŻ Treatment-related behavior (chemo / antibiotic adherence)! â˘âŻ Interactive game-play has wide impact on the brain! â˘âŻ Learning / knowledge ! Interactivity and Reward-Related Neural â˘âŻ Motivation / emotion! Activation! During a Serious Videogame! â˘âŻ Hippocampal activation may play a role in generalizing in-game experience to real-life behavior! Brian Knutson, Ph.D., Stanford University ! http://dx.plos.org/10.1371/journal.pone.0033909! Implications! â˘âŻ Psychological ârecipeâ for positive behavior change! â˘âŻ Neural biomarkers for optimizing interventions ! 12  12!
- 13. Thank you!