Glomerular Filtration rate and its determinants.pptx
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Platelet-rich Plasma vs. Cortisone Injections for the Non-surgical Treatment of Shoulder Pain
1. Platelet-Rich Plasma vs. Cortisone Injections
for the Non-Surgical Treatment of Shoulder
Pain
Alan M. Hirahara, M.D., FRCS(C)
Private Practice
Sacramento, CA USA
Medical Director Team Physician Consultant
Sacramento State Athletics Sacramento River Cats Oakland A’s
MiLB - AAA
2. Objective of Study
• To evaluate the outcomes of platelet-rich plasma
(PRP) injections vs cortisone injections in
patients with shoulder pain
• To reduce the risks of treating patients with
shoulder pain by using a safe, effective, non-
surgical treatment of shoulder pain
3. Introduction
• In the literature, outcomes vary significantly in treating
shoulder pain non-surgically
• Platelet-Rich Plasma (PRP) - Improved healing of soft
tissues & bone
• Cortisone carries risk of degeneration of tissue, AVN,
inhibition of cell proliferation
– PRP has not been shown to carry any risk
4. Study Design
• Case-control study
• Collection period: 1/09 – 12/11
• Pain scores, ASES scores taken every week for 1
month, then every month for 6 months
– ROM measured pre-injection / 4 wks post
5. Study Design
• All patients with shoulder pain
• Inclusions:
– failed NSAID’s and physical therapy regimen
• Exclusions:
– any trauma post-injection
– non-compliance with therapy protocol
– blood dyscrasias
6. PRP Technique
• 10 cc autologous blood drawn
• Using ACP system, blood spun for 5 minutes at 1500
RPM
• Platelet Rich-Plasma (PRP) collected
8. Patient Data
Study Group Control Group
• 186 patients • 299 patients
• 85 male / 101 female • 128 male / 171 female
• Age range: 17 – 86 years • Age range: 22 – 90 years
• Age average: 52.48 years • Age average: 54.09 years
10. All Patients
Pain Scores ASES Scores
7.0 80.0
6.0 70.0
5.0 60.0
4.0 50.0
3.0 40.0
2.0 30.0
20.0
1.0
10.0
0.0
0.0
Study Group Control Group
Study n = 186
* p < 0.05 for Months 4 – 6 & 3 – 6
Control n = 299
11. All Patients
ROM
160.0
140.0
120.0
100.0 Flexion - Study
Flexion - Control
80.0 Abduction - Study
Abduction - Control
60.0 External Rotation - Study
External Rotation - Control
40.0
20.0
0.0
Pre-Injection 4 Weeks
* No statistical significance between groups
12. Tendonopathy
Pain Scores ASES Scores
8.0 90.0
7.0 80.0
70.0
6.0
60.0
5.0
50.0
4.0
40.0
3.0
30.0
2.0
20.0
1.0 10.0
- -
Study n = 19
* p < 0.05 for Mo 6 & Mo 1 – 3, 6 Control n = 68
13. PASTA Lesions
Pain Scores ASES Scores
8.0
80.0
7.0
70.0
6.0
60.0
5.0
50.0
4.0 40.0
3.0 30.0
20.0
2.0
10.0
1.0
-
-
Study n = 23
* p < 0.05 for Wk 3 - Mo 6 & Mo 1, 4 - 6 Control n = 24
14. Full RC Tears
Pain Scores ASES Scores
8.0
80.0
7.0
70.0
6.0
60.0
5.0
50.0
4.0 40.0
3.0 30.0
20.0
2.0
10.0
1.0
-
-
Study n = 26
* No statistical significance between groups Control n = 48
15. Adhesive Capsulitis
Pain Scores ASES Scores
6.0 80.0
70.0
5.0
60.0
4.0
50.0
3.0 40.0
30.0
2.0
20.0
1.0
10.0
- -
Study n = 70
* No statistical significance between groups Control n = 84
16. Shoulder DJD
Pain Scores ASES Scores
7.0
80.0
6.0
70.0
5.0 60.0
50.0
4.0
40.0
3.0
30.0
2.0 20.0
10.0
1.0
-
-
Study n = 19
* No statistical significance between groups Control n = 39
17. Discussion
• Both PRP & Cortisone injections can help
relieve shoulder pain
• BUT PRP improves pain & function
significantly more
18. PRP – Superior to Cortisone
• Tendonopathy
• PASTA lesions
20. Conclusion
• PRP can help diminish pain and improve
function and ROM in patients with specific
shoulder pathologies more than cortisone but
with significantly less side-effects or risks
• Randomized study needed to confirm results