2. RTM: Radboud Translational Medicine
from molecule to man
Discovery Screening preclinical testing Clinical trials
Radboud University Nijmegen Medical Centre, The Netherlands
3. RTM: Radboud Translational Medicine
from molecule to man
Discovery Screening preclinical testing Clinical trials
Radboud University Nijmegen Medical Centre, The Netherlands
6. From human imaging to small animal imaging
Mouse Human
Uptake of 123I-IBF
by D2 receptors
Neurology Dopamine w/ 99mTc-TRODAT
99m
Tc-MIBI
Cardiovascular Stress 99mTc-MIBI
[99mTc] Minigastrin
Oncology Renal Cell Carcinoma
*functional imaging
15. FDG-PET: functional imaging
Monitor response to treatment
Pre treatment
4 weeks after
start of treatment
24 weeks after
start of treatment
Pre treatment
Dept. Nuclear Medicine, Radboud University Nijmegen Medical Centre
16. FDG-PET: functional imaging
Monitor response to treatment
Pre treatment
4 weeks after
start of treatment
24 weeks after
start of treatment
Pre treatment 1 week after start of
imatinib treatment
Dept. Nuclear Medicine, Radboud University Nijmegen Medical Centre
17. FDG-PET: functional imaging
Monitor response to treatment
Pre treatment
4 weeks after
start of treatment
24 weeks after
start of treatment
Pre treatment 1 week after start of
imatinib treatment
Dept. Nuclear Medicine, Radboud University Nijmegen Medical Centre
18. microPET/CT scanner
Radboud University Nijmegen Medical Centre, The Netherlands
19. Monitor the therapeutic effect
of a new anti-cancer drug
- 1 day
Radboud University Nijmegen Medical Center, The Netherlands
20. Monitor the therapeutic effect
of a new anti-cancer drug
- 1 day 1 day
Radboud University Nijmegen Medical Center, The Netherlands
21. Monitor the therapeutic effect
of a new anti-cancer drug
- 1 day 1 day 3 days
Radboud University Nijmegen Medical Center, The Netherlands
22. Monitor the therapeutic effect
of a new anti-cancer drug
- 1 day 1 day 3 days 7 days
Radboud University Nijmegen Medical Center, The Netherlands
26. microSPECT imaging
Radboud University Nijmegen Medical Centre, The Netherlands
27. Imaging transplated islets of Langerhans
Diabetes type 1: autoimmune destruction of insulin producing beta cells
Islet transplantation is a promising treatment for patients with type1 diabetes
AIM: Non-invasive in vivo determination of beta cell mass after islet transplantation.
In-111-DTPA-
Exendin
islets
Radboud University Nijmegen Medical Centre, The Netherlands
38. Drug development Research
Hoffmann La Roche
Novartis
Sanofi
Fuji Biotechnology
Future Chemistry
Immunomedics Inc.
Synaffix
Wilex
Milabs
Radboud University Nijmegen Medical Centre, The Netherlands
Hinweis der Redaktion
At the moment more than 180 million people worldwide suffer from diabetes and an increase of the incidence of diabetes is expected.
MIP maximum intensity projection VRT volume rendering technique