Design for Six Sigma (DFSS) is a proactive approach to product design that aims to prevent quality problems, while traditional Six Sigma is a reactive approach focused on improving existing processes. DFSS uses tools like Quality Function Deployment and Failure Mode and Effects Analysis during the design process to translate customer needs into engineering requirements and optimize designs to achieve high quality levels. Key challenges to implementing DFSS include overcoming cultural resistance to change and adapting new technical methods and tools. Leadership support is critical to making DFSS successful through clear communication of the quality vision and goals.