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Polycystic Ovary (Ovarian) Syndrome
Polycystic Ovary Syndrome ,[object Object],[object Object]
Associated morbidity of PCOS ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Stein-Leventhal Syndrome ,[object Object],[object Object],[object Object]
Correlation of Hyperandrogenism with Hyperinsulinism in Polycystic Ovarian Disease ,[object Object],[object Object],[object Object]
Insulin resistance and polycystic ovary syndrome: mechanism and implication for pathogenesis ,[object Object],[object Object],[object Object]
Polycystic Ovaries ,[object Object],[object Object]
Polycystic Ovaries ,[object Object],[object Object],[object Object]
Polycystic Ovaries ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Polycystic Ovaries
* Sonography of polycystic ovary.
A: Polycystic ovaries, showing increased size and a smooth white surface reflecting thickening of the capsule. B: Section through polycystic ovary, showing multiple cysts with diameter < 10 mm arranged around the periphery of the ovary. The stroma is increased, and the ovary enlarged. ©The Medical Journal of Australia 2004  www.mja.com.au  ISSN: 0025-729X
Diagnosis of PCOS
Opinion of Ricardo Azziz… ,[object Object],From “Controversy in Clinical Endocrinology, Diagnosis of PCOS: Premature Rotterdam Criteria Are Premature; J of Clinical Endo & Meta, 2006
Diagnosis of PCOS
Diagnosis of PCOS
Diagnosis of PCOS
Clinical Features of PCOS ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Young woman with PCOS showing facial hirsutism (A) and axillary acanthosis nigricans (B). The latter is associated with severe insulin resistance and hyperinsulinaemia and is an occasional finding in PCOS (photographs courtesy Dr John Casey, St Vincent’s Clinic, Sydney, NSW). ©The Medical Journal of Australia 2004  www.mja.com.au  ISSN: 0025-729X
Clinical Features of PCOS ,[object Object],[object Object]
*  Manifestations of polycystic ovary syndrome at different ages   ©The Medical Journal of Australia 2004  www.mja.com.au  ISSN: 0025-729X
Differential Diagnosis of PCOS ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Laboratory Tests for the differential Diagnosis of Androgen Excess ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
 
Flow diagram for the laboratory evaluation of amenorrhea. Such a scheme must be considered as an adjunct to the clinical evaluation of the patient. CAH -= congenital adrenal hyperplasia; DHEAS = dehydroepiandrosterone sulfate; FSH = follicle-stimulating hormone; HCA = hypothalamic chronic anovulation; PCO = polycystic ovary syndrome; PRL = prolactin; T = testosterone; TSH = thyroid-stimulating hormone. Originally from Rebar RW, The ovaries. In: Smith LH Jr, ed. Cecil textbook of medicine, ed. 18. Philadelphia. WB Saunders, 1992:1367)
Laboratory Tests for PCOS ,[object Object],[object Object],[object Object],[object Object],[object Object]
Laboratory Tests for PCOS ,[object Object],[object Object],[object Object],[object Object]
Laboratory Tests for PCOS ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Management of PCOS ,[object Object],[object Object],[object Object],[object Object],[object Object]
Management of PCOS ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Management of PCOS ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Management of PCOS ,[object Object],[object Object],[object Object]
Randomized, Double-Blind, Placebo-Controlled Trials of  Metformin  in PCOS
Management of PCOS ,[object Object],[object Object],[object Object],[object Object],[object Object]
[object Object],[object Object],[object Object],[object Object],Effects of  Metformin   and  Rosiglitazone , Alone and in Combination, in Nonobese Women with Polycystic Ovary Syndrome and Normal Indices of Insulin Sensitivity.
Effects of  Metformin   and  Rosiglitazone , Alone and in Combination, in Nonobese Women with Polycystic Ovary Syndrome and Normal Indices of Insulin Sensitivity. ,[object Object],[object Object]
Effects of  Metformin   and  Rosiglitazone , Alone and in Combination, in Nonobese Women with Polycystic Ovary Syndrome and Normal Indices of Insulin Sensitivity. ,[object Object],[object Object]
Management for Hirsutism ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Cyproterone Acetate ,[object Object],[object Object],[object Object],[object Object]
 
[object Object]
Management for Infertility ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Management for Infertility ,[object Object],[object Object],[object Object],[object Object]
Management for Infertility ,[object Object],[object Object],[object Object]
Oral Contraceptives  and  Glucose Tolerance/Insulin Sensitivity  in Women With PCOS: Clinical Trials
FIG. 1.  Case-control studies on  myocardial infarctions  associated with current use of  low-dose oral contraceptives  versus no current use. Odds ratios (ORs) are expressed with their 95% confidence interval. OR were adjusted for multiple confounding factors, depending on the study. The combined OR was weighted based on the variance of the ORs in each study.
FIG. 2.  Case-control studies on  ischemic strokes  associated with current use of  low-dose oral contraceptives  versus no current use. Odds ratios (ORs) are expressed with their 95% confidence interval. OR were adjusted for multiple confounding factors, depending on the study. The combined OR was weighted based on the variance of the ORs in each study.
The cardinal feature is functional ovarian hyperandrogenism. ©The Medical Journal of Australia 2004  www.mja.com.au  ISSN: 0025-729X

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Ovary Hyperstimulation 1

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  • 11. * Sonography of polycystic ovary.
  • 12. A: Polycystic ovaries, showing increased size and a smooth white surface reflecting thickening of the capsule. B: Section through polycystic ovary, showing multiple cysts with diameter < 10 mm arranged around the periphery of the ovary. The stroma is increased, and the ovary enlarged. ©The Medical Journal of Australia 2004 www.mja.com.au ISSN: 0025-729X
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  • 19. Young woman with PCOS showing facial hirsutism (A) and axillary acanthosis nigricans (B). The latter is associated with severe insulin resistance and hyperinsulinaemia and is an occasional finding in PCOS (photographs courtesy Dr John Casey, St Vincent’s Clinic, Sydney, NSW). ©The Medical Journal of Australia 2004 www.mja.com.au ISSN: 0025-729X
  • 20.
  • 21. * Manifestations of polycystic ovary syndrome at different ages ©The Medical Journal of Australia 2004 www.mja.com.au ISSN: 0025-729X
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  • 25. Flow diagram for the laboratory evaluation of amenorrhea. Such a scheme must be considered as an adjunct to the clinical evaluation of the patient. CAH -= congenital adrenal hyperplasia; DHEAS = dehydroepiandrosterone sulfate; FSH = follicle-stimulating hormone; HCA = hypothalamic chronic anovulation; PCO = polycystic ovary syndrome; PRL = prolactin; T = testosterone; TSH = thyroid-stimulating hormone. Originally from Rebar RW, The ovaries. In: Smith LH Jr, ed. Cecil textbook of medicine, ed. 18. Philadelphia. WB Saunders, 1992:1367)
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  • 33. Randomized, Double-Blind, Placebo-Controlled Trials of Metformin in PCOS
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  • 45. Oral Contraceptives and Glucose Tolerance/Insulin Sensitivity in Women With PCOS: Clinical Trials
  • 46. FIG. 1. Case-control studies on myocardial infarctions associated with current use of low-dose oral contraceptives versus no current use. Odds ratios (ORs) are expressed with their 95% confidence interval. OR were adjusted for multiple confounding factors, depending on the study. The combined OR was weighted based on the variance of the ORs in each study.
  • 47. FIG. 2. Case-control studies on ischemic strokes associated with current use of low-dose oral contraceptives versus no current use. Odds ratios (ORs) are expressed with their 95% confidence interval. OR were adjusted for multiple confounding factors, depending on the study. The combined OR was weighted based on the variance of the ORs in each study.
  • 48. The cardinal feature is functional ovarian hyperandrogenism. ©The Medical Journal of Australia 2004 www.mja.com.au ISSN: 0025-729X