1. Directionality of
higher-order auditory pathways
Determining causality in source space:
a FEM-aided MEG study
Dominic Portain
Burkhard Maess
A.D. Friederici
Max Planck Institute
for Human Cognitive and Brain Sciences Leipzig, Germany
Dominic Portain, Imaging Meeting 13.08.2012 Max Planck Institute for Human Cognitive and Brain Sciences

2. Overview
• Theoretical background • Study time course
• Task paradigm • Acquisition
• Data analysis • Discussion
Dominic Portain, Imaging Meeting 13.08.2012 Max Planck Institute for Human Cognitive and Brain Sciences

3. Pathway
functions
pSTG
Friederici, 2011
Dominic Portain, Imaging Meeting 13.08.2012 Max Planck Institute for Human Cognitive and Brain Sciences

4. Age influence Perani et al., PNAS 2011
Dominic Portain, Imaging Meeting 13.08.2012 Max Planck Institute for Human Cognitive and Brain Sciences

5. rior, middle, and inferior temporal gyrus, respectively; Pr:
us; F2: middle frontal gyrus; PrF3op: precentral gyrus/F3op
: superior temporal sulcus; AG: angular gyrus; Fusa: anterior
s; a, p, l, m, d, v: anterior, posterior, lateral, middle, dorsal,
ctively.
Paradigm
yrus and the frontal operculum in the frontal lobe.
ion – action cycle that is supported by these fronto-
eas connected through the arcuate fasciculus fibers
tom) permits the implementation of a motor-sound-
er than pure-sound-based, phoneme representation
•
d Poeppel, 2004). “Subject-object” paradigm
In such a model, articulatory
the primary and common ist deron which both
(“Wo objects Affe, den der Tiger zieht?”)
duction and speech perception develop and act, in
• fMRI evidence: Cooke 2002, Stromswold
with Liberman’s motor theory of speech (Liberman
, 2000).
1996
Vigneau 2006, NeuroImage
•
al working-memory loop
Activation in pSTG/STS duringSentence (and text) clusters. Top: sagittal projection map of the 161
Fig. 4. syntactic comprehension
activation peaks derived from studies on sentence (green) and syntactic
• Contrast in BA44 the
he issues investigated by neuroimaging concerns the
between phonological and semantic processing inbetween subject/object-first conditions
(light green) processing; clusters are segregated by the algorithm for spatial
classification and their standard error on the y and z axes (yellow). Note
that in the frontal lobe the peaks issued from studies investigating syntax
obe. As a matter of fact, lesion studies have not clearly
ether the analysis of language sounds and the processing are located more dorsally. In the temporal lobe, the spatial distribution of
meaning are segregated or not in the left F3. Recent sentence and syntax peak is not different. Bottom: four of the sentence
Dominic Portain, Imaging Meeting 13.08.2012 clusters are in closeMax Planck Institutesemantic ones, and clusters involved
relationship with for Human Cognitive and Brain Sciences
ns on this topic have produced contradictory results. In

6. Task
• Picture-Selection task
• 216 trials (Pilot, 18min)
304 trials (MEG, 25min)
• Tutorial: random trials
“Wo ist der Hase, den der Vogel schiebt?”
until 90% correct
“Wo ist der Hase, der den Vogel schiebt?”
• •Feedback: Correct response
immediate:
“Wo ist das Tier, das der Vogel schiebt?”
• delayed: Accuracy, Speed
“Wo ist das Tier, das den Vogel schiebt?”
Dominic Portain, Imaging Meeting 13.08.2012 Max Planck Institute for Human Cognitive and Brain Sciences

7. DWI
Procedure
Localizing individual dorsal path II
image
T1 + T2 Segmentation Head FEM source Source
image model localization space
MRT
restricting to
BA44 and pSTG
MEG
Electrode-
space localized causality research
signals signals analysis answer
Dominic Portain, Imaging Meeting 13.08.2012 Max Planck Institute for Human Cognitive and Brain Sciences

8. Time course Goals
Pilot (behavioral) Task is quickly solvable
now
20 children, aged 10 Prevention of mental shortcuts
Hypotheses
Oct Main (MEG) Information flow along D2
2012 30 children, aged 10 Early top-down modulation
early Control (MEG)
Dependency on development of D2
2013 30 adults
Dominic Portain, Imaging Meeting 13.08.2012 Max Planck Institute for Human Cognitive and Brain Sciences

9. MEG
Acquisition 1000 Hz resolution
330 Hz bandwidth
horizontal acquisition
T1_mpr_sag_ADNI_12ch T2_spc_sag_P2_iso DWI_standard_12ch
12-channel head coil
12-channel head coil 12-channel head coil
Flip angle: 9°
Flip angle: 120° Flip angle: 90°
Repetition time: 2300ms
Repetition time: 3200ms Repetition time: 12.9s
Echo time: 2.96ms
Echo time: 402ms Echo time: 100ms
Inversion time: 900ms
Matrix: 256x258 Matrix: 128x128
Matrix: 256x240
FOV: 250x250x176 mm FOV: 220x220x151mm
FOV: 256x240x176 mm
Resolution: 0.5x0.5x1mm Resolution: 1.7x1.7x1.7mm
Resolution: 1x1x1mm
~7min ~9.5min ~19min
= 36min x 30 subjects
Dominic Portain, Imaging Meeting 13.08.2012 Max Planck Institute for Human Cognitive and Brain Sciences

10. Special thanks:
• Alfred Anwander
• Michael Skeide
• Christine Schipke
• Maria Felber
• Jens Brauer
• Katja Kirsche
• Yvonne Wolff
XXX Max Planck Institute for Human Cognitive and Brain Sciences