The document introduces CACHEfx scalable caching appliances which use high-speed memory to overcome disk-based I/O bottlenecks and accelerate data center systems. CACHEfx appliances seamlessly integrate into existing infrastructures, initially focusing on accelerating NAS/NFS and clustered file systems. They deliver high performance in terms of low latency, high IOPS, and high throughput while supporting thousands of clients and scaling to multiple terabytes. Production customers have seen up to 5x application performance increases and 85% reductions in filer load with CACHEfx appliances.