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The Journal of Arthroplasty Vol. 20 No. 2 2005




        A Comparison of 2 Continuous Passive Motion
           Protocols After Total Knee Arthroplasty
                                A Controlled and Randomized Study

                     Lisa A. Bennett, BAppSc, MPhty,* Sara C. Brearley, BAppSc,y
                     John A. L. Hart, MBBS, FRACS, FA, Orth A, FASMF, FACSP,z
                                   and Michael J. Bailey, BSc, MSc§


                     Abstract: Effect of continuous passive motion (CPM) protocols on outcomes after
                     total knee arthroplasty. In this prospective randomized controlled study, 147
                     patients were assigned to 1 of 3 treatment groups: CPM from 08 to 408 and increased
                     by 108 per day, CPM from 908 to 508 (early flexion) and gradually progressed into
                     full extension over a 3-day period, and a no-CPM group. The CPM was administered
                     twice a day for 3 hours over a 5-day period. All patients participated in the same
                     postoperative physiotherapy program. Patients were assessed preoperatively, day 5,
                     3 months, and 1 year postoperatively. The early flexion group had significantly more
                     range of flexion than both the standard and control groups at day 5. There was no
                     significant difference between the groups for any other variable tested at any time
                     frame. Key words: total knee arthroplasty, CPM, rehabilitation, outcomes.
                     n 2005 Elsevier Inc. All rights reserved.




Continuous passive motion (CPM) can be applied to                             tion was detrimental to joints, motion was benefi-
the knee joint by a mechanical device that moves                              cial, and CPM minimized forces across damaged
through a preset range of motion (ROM) at a                                   joint surfaces. For motion to be continuous, it has to
selected velocity. Salter [1-3] researched and devel-                         be applied passively, as muscles would fatigue with
oped the concept of CPM after experiments in rabbits                          continuous active movement of a joint [1-3].
where he demonstrated that articular cartilage                                   Continuous passive motion devices have been
defects and intra-articular fractures healed better                           widely used as an adjunct to physiotherapy after
when CPM was used. He believed that immobiliza-                               total knee arthroplasty (TKA) for the past 2
                                                                              decades [4]; however, there is controversy as to
                                                                              whether it is useful. Numerous studies have been
   From the *Department of Physiotherapy, The Alfred, Melbourne,              carried out on the effects of CPM after TKA.
Australia; yDepartment of Physiotherapy, Caulfield General Medical            Parameters such as knee ROM, length of stay
Centre, Melbourne, Australia; zDepartment of Surgery, The Alfred,
Monash University, Melbourne, Australia, and §Department of                   (LOS), wound healing, and knee function have
Epidemiology and Preventative Medicine, Monash University, Australia.         been evaluated with contradictory results. Some
   Submitted October 27, 2003; accepted August 9, 2004.                       [4-12] recommend CPM, whereas others [13-18]
   Benefits or funds were received in partial or total support of
the research material described in this article from the Alfred,              have found it to be of little value in rehabilitation of
Melbourne, Australia (small projects grant).                                  the knee after TKA. The differences in outcomes can
   Reprint requests: (From 15 October 2004 to 15 October 2005)                be explained partly by variations in study design and
Sara C Brearley, Physiotherapy Rehabilitation Department,
Caulfield 3162, Victoria, Australia. (From 16 October 2005) Lisa              methodology. Differences in the duration of appli-
Bennett, Physiotherapy Department, The Alfred, Commercial                     cation of CPM ranging from as little as 4 hours a day
Road, Prahran 3182, Australia.                                                [15] to almost 24 hours per day [19] have been
   n 2005 Elsevier Inc. All rights reserved.
   0883-5403/04/2002-0013$30.00/0                                             reported. Some studies [13,15,19-21] have included
   doi:10.1016/j.arth.2004.08.009                                             small samples, which may affect validity.



                                                                        225
226 The Journal of Arthroplasty Vol. 20 No. 2 February 2005

   The primary motions of the knee joint are flexion         flexion and 08 extension of the knee, decreasing
and extension [22]. Traditionally, CPM has been              LOS, and improving knee function.
administered by moving the knee from full exten-          2. There would be no difference in wound healing
sion through increasing degrees of flexion [19]. For         between the 3 groups.
the purposes of this paper, we refer to this method as
standard CPM. More recently, an early flexion
                                                                        Materials and Methods
regime has been advocated in which the knee is
progressively moved from flexion to extension
                                                          Study Design
[21,23-25]. Jordan et al [23] conducted a non-
randomized trial comparing standard and early               Patients were allocated by a block randomization
flexion CPM after primary TKA. Early flexion              procedure into 1 of 3 groups:
resulted in decreased LOS, decreased hospital costs,
and increased ROM at 1 year. On the other hand,           ! Group A: Standard CPM regime
MacDonald et al [24] found no statistical differences,    ! Group B: Early flexion CPM regime
at any measured interval, between standard and            ! Group C: No CPM (the control group).
early flexion CPM regimes and a no-CPM group.                The operating surgeon and the independent
Their randomized trial evaluated cumulative anal-         assessor were blinded to the group allocation of the
gesic requirements, ROM, LOS, and Knee Society            subjects, and the subjects were blinded to the study
scores. The authors acknowledge, however, that a          hypotheses. To determine the number of subjects
longer trial of CPM may have benefited these              required to achieve statistical significance, a power
patients as CPM was only utilized for a maximum           analysis was performed. The sample size was based
of 24 hours postoperatively. Our study is the first       on 3 pairwise comparisons of the groups each at a
prospective randomized controlled trial comparing 2       significance level of 1.7% (=5%/3) at 5 days after
CPM protocols where the CPM has been adminis-             operation. To detect a difference of 78 knee ROM
tered over a significant period of time.                  between groups with an SD of 108 within each
                                                          group, the study needed to recruit 43 subjects per
                  Aims of The Study                       group to achieve 80% power. It is generally accepted
                                                          that goniometric measurements of the knee have an
  The aims of the research were to assess                 error rate of F58 [26]. If a 78 ROM difference existed
                                                          in our study, this would represent a true difference
1. The effect of CPM after TKA on knee ROM,               between the groups A, B, and C rather than a
   length of hospital stay, wound healing, knee           difference due to measurement error.
   function, and perceived health status.
2. Whether early flexion CPM produces a better            Study Cohort
   outcome than a standard CPM regime or control
   with no CPM.                                             One hundred forty-eight patients were initially
                                                          recruited into the study. One patient was subse-
Hypotheses                                                quently excluded from the study, as we were
                                                          unable to achieve 908 knee flexion on the CPM
1. Early flexion CPM would be more effective than         device in recovery. Results were analyzed for the
   standard CPM and no CPM in achieving 908               remaining 147 patients. They were admitted to The



                                       Table 1. Demographic Information

                                        A                           B                      C
Group                            (Standard CPM)           (Early flexion CPM)          (No CPM)            Total

Patients (N)                          47                         48                      52                 147
Gender (% female)                     72.3                       64.6                    67.3
Mean age (y)                          70.7                       71.4                    71.7
Genesis I prosthesis (N)               7                          5                       7                  19
Genesis II prosthesis (N)             40                         43                      45                 128
Cruciate retained (N)                 43                         41                      46                 130
Posterior stabilized (N)               4                          7                       6                  17
Patella resurfaced (N)                22                         24                      28                  74
Patella not resurfaced (N)            25                         24                      24                  73
Continuous Passive Motion Protocols After Total Knee Arthroplasty ! Bennett et al 227

               Table 2. Physiotherapy Program                           prostheses were again used at the discretion of the
                                                                        operating surgeon (Table 1). The patella was not
Commencing day 1 postoperatively
Ankle dorsi flexion/plantar flexion
                                                                        routinely resurfaced, at the discretion of the treat-
Static quadriceps progressing to quadriceps over a fulcrum              ing surgeon (Table 1).
  (active-assisted to active)                                              Two Redivac drains were inserted and later
Static gluteals
Gentle active/active-assisted hip knee flexion on a
                                                                        removed at 48 hours. An attempt was made to
  powder board                                                          standardize the anesthetic protocol, but because of
Chest care as indicated                                                 individual patient requirements this was not
On day 2
                                                                        possible. There was no significant difference be-
Exercises as above progressing to independent straight leg raise        tween the groups A, B, and C according to
Transfer out of bed and sit out of bed in a chair if tolerated          anesthetic techniques.
On day 3
Exercises as above                                                      Physiotherapy Program
Knee flexion over the side of the bed
Ambulation with gait aids, full weight bearing initiated                   All patients participated in a standardized phys-
                                                                        iotherapy program (Table 2).
Day 4 onward
Knee flexion and extension ROM and strength, gait
  reeducation, and steps practiced. Patients with a
  quadriceps lag greater than 108 ambulated with                                          CPM Protocols
  EKS until adequate knee control obtained
Program conducted half an hour twice a day                              Group A: Standard
  except on weekends when patients were seen once a day
                                                                           Day 1 (operative day): CPM machine applied in the
                                                                        recovery room set at 08 to 408 for 3 hours. The CPM
                                                                        was removed and extension knee splint (EKS) ap-
Alfred, Melbourne, between January 1997 and July                        plied to maintain the knee in extension overnight.
2000 for surgery using a Genesis I or II prosthesis                        Day 2: CPM machine applied early in the
(Smith and Nephew, Memphis, Tenn). All had a                            morning at 08 to 458 for 3 hours and reapplied late
primary diagnosis of osteoarthritis. Those excluded                     afternoon at 08 to 508 for 3 hours. Extension knee
had bilateral TKA performed at the same time,                           splint applied overnight.
revision of TKA, rheumatoid arthritis, or hemophil-                        Days 3 to 6: CPM increased 58 twice a day until
ia. Demographic information is described in Table 1.                    ceased on day 6. Extension knee splint applied
                                                                        overnight.
Surgical Procedure
                                                                        Group B: Early Flexion
  Initially, Genesis I TKA prostheses were used
exclusively in the study, but this protocol changed                        Day 1 (operative day): CPM machine was applied
to Genesis II when the prosthesis became available.                     in the recovery room at 908 to 508 knee flexion.
Ten experienced surgeons working in 2 surgical                          The CPM machine was cycled between 908 and 508
units at The Alfred performed the operations.                           flexion for 3 hours. Knee rested at 908 flexion on
Trainee registrars supervised by the senior surgeons                    the machine overnight.
performed some procedures. An anteromedial or                              Day 2: CPM between 908 and 408 for 3 hours.
midline incision was used, and the knees were                           Continuous passive motion was turned off but
approached through a medial parapatellar capsular                       remained in situ with the knee resting in 908 flexion
incision. Cruciate retaining and posterior-stabilized                   on the machine. Continuous passive motion applied



                                                   Table 3. Mean Knee Flexion

CPM Group                      A (Standard)                        B (Early Flexion)                        C (None)
Knee ROM          Active Flexion      Passive Flexion      Active Flexion    Passive Flexion   Active Flexion    Passive Flexion

Time
Preoperative          102.58              108.38               102.58            108.68            102.68              108.88
Day 5                  69.48               75.38                78.78             86.68             64.98               71.28
3 mo                   95.08                                    95.88                               93.78
1y                    102.78                                   102.58                              102.98
228 The Journal of Arthroplasty Vol. 20 No. 2 February 2005

               Table 4. Mean Passive Knee Extension (Fixed Flexion Deformity) and Quadriceps Lag
CPM Group                  A (Standard)                      B (Early Flexion )                        C (None)
Knee ROM       Quadriceps Lag    Passive Extension   Quadriceps Lag    Passive Extension   Quadriceps Lag   Passive Extension

Time
Preoperative        2.08                  9.38            2.28               9.78               1.88              10.08
Day 5              12.18                  6.28           11.68               7.78              12.98               6.58
3 mo                2.38                  7.28            3.28               8.78               1.68               6.48
1y                  1.08                  3.68            1.58               3.48               0.18               4.18




late afternoon at 908 and 308 flexion for 3 hours,                  Analgesic requirements were not controlled in
and the knee was rested in 908 flexion overnight.                this study. If one patient group experienced
   Day 3: CPM between 908 and 208 for 3 hours in                 significantly more pain than the others, this could
the morning and between 908 and 108 for 3 hours                  influence postoperative recovery and, hence, have
in the afternoon. The CPM was then removed and                   an impact on the results. However, a specialized
EKS applied overnight.                                           pain team monitored these patients postoperative-
   Day 4: CPM between 908 and 08 for 3 hours in                  ly, and pain levels were recorded using a visual
the morning and afternoon. The CPM was removed                   analogue scale twice a day when the machine was
and the EKS applied overnight.                                   not cycling, for the first five postoperative days.
   Days 5 to 6: CPM between 908 and 08 for 3 hours
in the morning and afternoon. Extension knee
                                                                                      Data Analysis
splint in bed at night. Continuous passive motion
ceased at the end of day 6.
                                                                    Means and standard errors were computed for
                                                                 each group at each time point (baseline, 5 days, 3
Group C: No CPM
                                                                 months, 1 year). Univariate analysis was conducted
  EKS in theater and remained in situ when in bed                using v 2 tests for categorical variables and analysis of
overnight and removed during the day. The patient                variance for continuous normally distributed data.
received no CPM.                                                 Where data were found to be log-normally distrib-
                                                                 uted (LOS, passive extension, and quadriceps lag), a
                                                                 log transformation was performed before analysis.
                   Measurements                                  Multivariate analysis was conducted using a repeat
                                                                 measures analysis of covariance adjusting for base-
  Data were collected from each patient in the                   line prognostic factors. Wound healing and perio-
preoperative period (at a preadmission clinic) and               perative anesthetic requirements were evaluated
postoperatively at 3 months and 1 year.                          using v 2 tests for equal proportion. Perceived health
1. Knee flexion, extension, and quadriceps lag                   status, measured on an ordinal scale, was evaluated
   were measured in degrees with a standard                      using nonparametric analysis.
   universal goniometer [26]. These measurements
   were also taken on the fifth postoperative day.                                         Results
2. Knee function was assessed using the functional
   component of the Knee Society Clinical Rating                 Range of Motion
   System [27].
3. Perceived health status of each patient was                      Preoperatively, there were no statistically signif-
   assessed using the Short-Form 12-Item Health                  icant differences between the 3 groups in mean
   Survey (SF-12) [28].
  On the fifth postoperative day, wound healing was
evaluated using the following classification system:                  Table 5. Length of Hospital Stay (Acute) in Days
aseptic wound discharge, aseptic wound dehiscence,               Group                         N        Geometric Mean LOS
superficial infection, or deep infection [8]. Wound
healing was considered to have failed if there was               A (Standard CPM)             47                  8.8
infection or aseptic dehiscence of the wound.                    B (Early flexion CPM)        48                  8.1
                                                                 C (No CPM)                   52                  8
  Hospital (inpatient) LOS was recorded in days in               P                            .51
the acute and rehabilitation settings.
Continuous Passive Motion Protocols After Total Knee Arthroplasty ! Bennett et al 229

  Table 6. Length of Hospital Stay (Rehabilitation)                             Table 8. Wound Healing
                      in Days
                                                                Wound Healing
Group                         N       Geometric Mean LOS        (5th Postoperative Day)         Yes        (N)      No         (N)

A (Standard CPM)               32               18.7            A (Standard CPM)               93.5%        43      6.5%       3
B (Early flexion CPM)          29               17.8            B (Early flexion CPM)          98%          47      2%         1
C (No CPM)                     39               15.8            C (No CPM)                     92.3%        48      7.7%       4
P                             .58                               P                                .44




passive or active flexion (Table 3), or in quadri-              Pain
ceps lag or passive extension (Table 4). At day
5 postoperatively, there were significant differ-                  The mean of the 10 visual analogue scale scores
ences between the groups in active flexion                      for each patient was calculated; hence, a score out
( P = .008 and P b .0001) and passive flexion                   of 10 was determined. There are statistically
( P = .007 and P b .0001) (Table 3). At 3 months                significant differences in mean pain scores between
and 1 year postoperatively, there were no signif-               groups A and B ( P b .0001), groups B and C ( P =
icant differences between the groups in active                  .005), and groups A and C ( P = .013) (see Table 7).
flexion, passive extension, and quadriceps lag.                 These differences are, however, not clinically
(Tables 3 and 4).                                               significant as they represent less than or equal to 1
                                                                point on a 10-point scale.
Length of Stay
                                                                Wound Healing
   Patients were discharged home when the mul-
tidisciplinary team assessed them as being able to                 Healing rates for the groups are represented in
manage safely in their home environment. Some                   Table 8. A v 2 analysis revealed that there was no
patients were transferred to a rehabilitation                   significant difference between the groups in wound
facility for ongoing therapy before discharge.                  healing rates ( P = .44).
Length of acute hospital stay (in days) for the
3 groups was 8.8 for group A, 8.1 for group B,                  Knee Function
and 8.0 for group C. There was no significant                     Knee function was assessed using the Knee
difference between the groups ( P = .51) (Table 5).             Society Clinical Rating System [29]. There was
One hundred patients went to a rehabilitation                   no significant difference between the 3 groups
facility. Of these, 32 were in group A (geometric               preoperatively, at 3 months or at 1 year (Table 9).
mean LOS = 18.7 days), 29 were in group B
(geometric mean LOS =17.8 days), and 39 were in                 Perceived Health Status Measure SF-12
group C (geometric mean LOS =15.8 days). There
was no significant difference between the groups                   The SF-12 is a shorter version of the SF-36
( P = .58) (Table 6).                                           used to reproduce its Physical Component Sum-
                                                                mary (PCS) and Mental Component Summary
                                                                (MCS) scores [28]. There was no significant
                                                                difference between the groups in PCS and MCS
                                                                preoperatively, nor at 3 months and 1 year
                                                                postoperatively.
        Table 7. Visual Analogue Scale Scores

                                              Mean
                                            Score Over
Group         Day 1 Day 2 Day 3 Day 4 Day 5   5 days
                                                                        Table 9. Knee Society Scores: Function
A (Standard    4.1      3.7   3.5   3.4   3.2          3.6                        (Means and SEs)
  CPM)
B (Early       3.2      2.9   2.5   2.3   2.4          2.6      CPM group               A                  B               C
  flexion
  CPM)                                                          Preoperative      40.1 (3.0)           42.1 (3.0)      45.3 (2.8)
C (No CPM)     3.5      3.1   3.1   3.1   2.9          3.1      3 mo              51.9 (3.6)           52.2 (3.2)      56.0 (3.0)
P                                                      b.0001   1y                57.9 (3.6)           59.6 (3.4)      58.1 (3.1)
230 The Journal of Arthroplasty Vol. 20 No. 2 February 2005

                    Discussion                            In contrast, Harms and Engstrom [4] found that
                                                          CPM resulted in a significant improvement in knee
Flexion: Early Postoperative Phase                        extension. In our study, we found no significant
                                                          differences between the groups in passive knee
   The present study demonstrated a significant           extension at 3 months nor at 1 year. Other authors
improvement in active and passive knee flexion            have reported the same finding [10,19,24,25].
at day 5 postoperatively in group B compared to
groups A and C. McInnes et al [9] reported that           Quadriceps Lag
standard CPM significantly increased active flexion
at 1 week postoperatively but not at 6 weeks.               We found no significant differences between the
Harms and Engstrom [4] found knee flexion was             groups in quadriceps lag at day 5, 3 months, and 1
increased in a standard CPM group when compared           year postoperatively. Other authors [23-25] did not
with a no-CPM group. Yashar et al [25] found a            examine quadriceps lag in their publications. Ng
significant difference in passive knee flexion in         and Yeo [21] found no significant differences
favor of an early flexion group. Other studies have       between groups in active extension on the fifth
reported no significant differences [19-21].              postoperative day.

Flexion: Late Postoperative Phase                         Length of Stay

   At 3 months and 1 year postoperatively, there             There were no significant differences between
was no significant difference between the groups in       the groups in acute or rehabilitation hospital
active or passive knee flexion in our study. This is      inpatient LOS, which is in agreement with Yashar
in agreement with the findings of other studies at        et al [25] and MacDonald et al [24], but is in
3-, 6-, and 12-month evaluations [17,19,24,25]. In        contrast to the findings of the nonrandomized
contrast, Jordan et al [23] in a nonrandomized            study on 100 TKA patients by Jordan et al [23].
study reported that an early flexion CPM regime           The latter authors reported that the early flexion
produced increased flexion ROM at 1 year com-             resulted in decreased LOS and decreased hospital
pared with standard CPM.                                  costs and improved ROM at 1 year. Our acute
   The average active range of knee flexion in our        hospital LOS for all groups was higher than that
study, at 1 year postoperatively, was 1038 for all        reported by MacDonald et al [24]. There are a
groups. This value is lower than the 1128 average         number of possible reasons for this including
knee flexion reported by MacDonald et al [24] and         patient demographics. MacDonald et al [24] ex-
Yashar et al [25]. The likely explanation for this        cluded patients older than 80 years and those who
difference is that postoperative ROM is influenced        were unable to ambulate 30 m and climb 10 steps.
by preoperative ROM [30]. In our study, the patients      In our study, age was not an exclusion criterion
were all public hospital patients and mean preoper-       and some of our patients were virtually wheelchair
ative active flexion was 102.68 (Table 3). In a cohort    bound before surgery because of a long waiting list.
treated privately, the average preoperative flexion       These are important factors in outcome. Further-
was 111.58 and the postoperative flexion was 111.68.      more, MacDonald et al [24] excluded patients if
MacDonald et al [24] reported a mean preoperative         they had fixed flexion deformities greater than 158,
range of 1068, whereas Yashar et al [25] reported a       whereas in our study 17 patients had deformities of
mean preoperative ROM of 1108. The mean age of            that magnitude. Thus, over 10% of our subjects
patients in our study was 71 years. In the study of       had severe degenerate disease of the knee preop-
MacDonald et al [24], the mean age was not stated,        eratively, which would have contributed to a
but patients older than 80 years were excluded, as        slower recovery. Johnson [7,8] found LOS was
were those with a greater than 158 fixed flexion          significantly reduced after the use of standard CPM
deformity. In the study of Yashar et al [25], the mean    compared with control. However, others [4,9] have
age was 69 years. In our study, increased patient age     found no significant difference in LOS between
and stiffer knees preoperatively may have contrib-        standard and control groups. Local discharge poli-
uted to the reduced range of movement.                    cies and the availability of rehabilitation facilities
                                                          also affect length of acute hospital stay.
Extension
                                                          Wound Healing
  We found no statistically significant differences
between the groups in passive extension in the first        Johnson [7] reported that transcutaneous oxy-
postoperative week, as did previous authors [9,21].       gen tension on the lateral aspect of the incision
Continuous Passive Motion Protocols After Total Knee Arthroplasty ! Bennett et al 231

decreased as the knee flexed past 408; hence, we              preoperatively (Table 10). The reason for this is not
were somewhat concerned about the risk of wound               clear. The number of complications in the no-CPM
breakdown in the early flexion group. In the                  group was not significantly different when com-
present study, the early flexion group knees were             pared to the CPM groups at 3 months and 1 year.
maintained in 908 flexion overnight for 2 nights,             Adequate test-retest reliability using the SF-12 was
but there were no significant differences between             demonstrated by Ware et al [28]: PCS = 0.89 and
the groups in wound healing when assessed on the              MCS = 0.76. This measurement tool was designed
fifth postoperative day, which agrees with Yashar et          for large group studies with patient populations
al [25]. Our early flexion group had fewer wound              greater than 500 [28]. Therefore, it may not be the
complications than the control or standard groups             most reliable tool to estimate perceived health
(Table 8). Ververeli et al [12] also found that there         status in clinical applications such as the present
was no significant difference in wound healing                study.
between standard and no-CPM groups.
                                                              Study Limitations and Suggestions
Knee Function                                                 for Future Research

   The functional component of the Knee Society                  Our patients attended a preadmission clinic
Clinical Rating System [29] was used as a mea-                where they received education, written informa-
surement tool in this study. It demonstrates good             tion about TKA, and a personalized exercise
responsiveness when used to assess outcome after              program to be commenced before their operation.
TKA [27]. Despite a 5-point difference in preoper-            Attendance at this clinic may have influenced the
ative Knee Society function scores between control            results in favor of the no-CPM group. Postopera-
and standard CPM groups (Table 9), there were no              tively patients were given 2 half-hour sessions of
statistically significant group differences preopera-         physiotherapy daily during the week and 1 half-
tively. In addition, there were no statistically              hour session on weekends. This intensive program
significant differences at 3 months or 1 year                 is not readily available in all hospitals. The role of
between control and CPM treatment groups. Sim-                CPM in the early postoperative management of
ilarly, MacDonald et al [24] also found that there            patients who are medically or psychologically
were no differences between the control and CPM               impaired was not addressed in our study and may
groups preoperatively and at 1 year when evaluat-             require further investigation. Colwell and
ed using the Knee Society scoring system. McInnes             Morris [19] found that isolating outliers made the
et al [9] reported no significant differences between         LOS significantly different between a no-CPM
standard CPM and control groups in knee function              group and a standard CPM group.
at 6 weeks after TKA.                                            Statistical tests are for means and assess whether
                                                              the means of different groups are statistically
Perceived Health Status                                       different. This conclusion fails to identify individ-
                                                              uals or subgroups that may have benefited from the
  The Medical Outcomes Study SF-12 includes 12                intervention. Thirty-three of the 147 patients
questions from the SF-36. No other authors                    evaluated in this study had a preexisting fixed
evaluating the effects of CPM on TKA have used                flexion deformity (FFD) of 158 or more. We
the SF-12. In the present study, we found no dif-             analyzed the day 5 postoperative results of these
ferences in SF-12 scores preoperatively, at 3                 patients for the purpose of generating ideas for
months or at 1 year between the 3 groups. How-                future research. Statistical analysis of this subgroup
ever, the PCS for the control group was signifi-              showed that these patients had statistically signif-
cantly worse at 1 year postoperatively compared to            icant increases in quadriceps lag ( P = .0005) and



                                     Table 10. SF-12 Scores (Means and SEs)

Group                  A (Standard CPM)                 B (Early Flexion CPM)                     C (No CPM)
SF-12                PCS              MCS               PCS                MCS               PC                MCS

Preoperative      38.0 (2.0)        48.1 (1.8)       42.2 (2.0)          45.7 (1.8)       43.4 (1.8)       44.5 (1.7)
3 mo              39.4 (2.3)        50.4 (2.1)       38.4 (2.1)          53.3 (1.9)       39.5 (1.9)       54.1 (1.8)
1y                43.8 (2.4)        54.3 (2.2)       40.0 (2.3)          54.4 (2.1)       37.8 (2.1)       54.3 (1.9)
232 The Journal of Arthroplasty Vol. 20 No. 2 February 2005

passive extension loss ( P b .0001) when compared                    an experimental investigation in the rabbit. J Bone
to the rest of the group (patients with a FFD V108).                 Joint Surg 1980;62A:1232.
We also analyzed the FFD subgroup according to                 3.    Salter RB: Motion vs rest: why immobilize joints? J
CPM group allocation (A, B, C). There were no                        Bone Joint Surg 1982;64B:251.
                                                               4.    Harms M, Engstrom B. Continuous passive motion as
statistically significant differences in quadriceps lag
                                                                     an adjunct to treatment in the physiotherapy man-
or passive extension loss between the groups.
                                                                     agement of the total knee arthroplasty patient.
Unfortunately, the sample size was small and a                       Physiotherapy 1991;77:301.
larger sample of patients with clinically significant          5.    Coutts RD, Toth C, Kaita JH. The role of continuous
preexisting FFD would need to be evaluated to                        passive motion in the rehabilitation of the total knee
determine whether CPM makes a difference for                         patient. In Hungerford DS, Krackow K, Kenna RV,
some patients after TKA.                                             editors. Total knee arthroplasty: a comprehensive
                                                                     approach (p. 126). Baltimore: Williams & Wilkins;
                                                                     1984.
                     Conclusion                                6.    Coutts RD. Continuous passive motion in the reha-
                                                                     bilitation of the total knee patient: its role and effect.
   The results of this study show that an early                      Orthop Rev 1986;15:27.
flexion CPM regime is useful in achieving a better             7.    Johnson DP. The effect of continuous passive motion
range of active and passive flexion in the early                     on wound healing and joint mobility after knee
postoperative period after TKA, but did not result in                arthroplasty. J Bone Joint Surg 1990;72A:421.
decreased LOS. Length of stay is, however, multi-              8.    Johnson DP, Eastwood DM. Beneficial effects of
factorial and influenced by social issues in addition                continuous passive motion after total condylar knee
                                                                     arthroplasty. Ann R Coll Surg Engl 1992;74:412.
to joint function. We were unable to demonstrate
                                                               9.    McInnes J, Larson MG, Daltroy LH, et al. A controlled
any significant difference between standard and
                                                                     evaluation of continuous passive motion in patients
early flexion CPM and control groups after dis-                      undergoing total knee arthroplasty. JAMA 1992;
charge. There was no difference in wound healing                     268:1423.
rates, functional outcome, or perceived health                 10.   Maloney WJ, Schurman DJ, Hangen D, et al. The
status. From these results, we have been unable                      influence of continuous passive motion on outcome
to justify the use of CPM as a routine rehabilitation                in total knee arthroplasty. Clin Orthop 1990;256:162.
tool in the public hospital setting after TKA. The             11.   Romness DW, Rand JA. The role of continuous
role of CPM in the management of patients with                       passive motion following total knee arthroplasty.
difficult problems or in facilities where manpower                   Clin Orthop 1988;226:34.
is limited warrants further study.                             12.   Ververeli PA, Sutton DC, Hearn SL, et al. Continuous
                                                                     passive motion after total knee arthroplasty —
                                                                     analysis of costs and benefits. Clin Orthop 1995;
                                                                     321:208.
                Acknowledgments                                13.   Chiarello CM, Gundersen MS, O’Halloran T. The
                                                                     effect of continuous passive motion duration and
   This research was supported by an Alfred                          increment on range of motion in total knee arthro-
Hospital small project grant. The authors wish to                    plasty patients. J Orthop Sports Phys Ther 1997;
acknowledge Helen Donaldson of Smith and                             25:119.
Nephew Surgical Pty Ltd for her extensive role in              14.   Kumar PJ, McPherson EJ, Dorr LD, et al. Rehabili-
data collection. We would also like to thank Lara                    tation after total knee arthroplasty — a comparison of
Kimmel and members of the physiotherapy de-                          2 rehabilitation techniques. Clin Orthop 1996;
                                                                     331:93.
partment at The Alfred for treating the patients,
                                                               15.   Nielson PT, Rechnagel K, Nielsen SE. No effect of
and the surgeons of the Department of Orthopedic                     continuous passive motion after arthroplasty of the
Surgery for allowing their patients to participate in                knee. Acta Orthop Scand 1988;59:580.
the study.                                                     16.   Pope RO, Corcoran S, McCaul K, et al. Continuous
                                                                     passive motion after primary total knee arthro-
                                                                     plasty — does it offer any benefits? J Bone Joint Surg
                     References                                      Br 1997;79B:914.
                                                               17.   Ritter MA, Gandolf VS, Holston KS. Continuous
1. Salter RB, Field P. The effects of continuous com-                passive motion versus physical therapy in total knee
   pression on living articular cartilage: an experimental           arthroplasty. Clin Orthop 1989;244:239.
   investigation. J Bone Joint Surg 1960;42A:31.               18.   Nadler SF, Malanga GA, Zimmerman JR. Continuous
2. Salter RB, Simmonds DF, Malcolm BW, et al. The                    passive motion in the rehabilitation setting. A
   biological effect of continuous passive motion on the             retrospective study. Am J Phys Med Rehabil 1993;
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Continuous Passive Motion Protocols After Total Knee Arthroplasty ! Bennett et al 233

19. Colwell CW, Morris BA. The influence of continuous       25. Yashar AA, Venn-Watson E, Welsh T, et al. Contin-
    passive motion on the results of total knee arthro-          uous passive motion with accelerated flexion after
    plasty. Clin Orthop 1992;276:225.                            total knee arthroplasty. Clin Orthop 1997;345:38.
20. Chen B, Zimmerman JR, Soulen L, et al. Continuous        26. Clarkson HM, Gilewich GB. Musculoskeletal assess-
    passive motion after total knee arthroplasty: a              ment: joint range of motion and manual muscle
    prospective study. Am J Phys Med Rehabil 2000;9:             strength. Baltimore: Williams and Wilkins; 1989.
    421.                                                     27. Kreibich DN, Vaz M, Bourne RB, et al. What is the
21. Ng TS, Yeo SJ. An alternative early knee flexion             best way of assessing outcome after total knee
    regime of continuous passive motion for total knee           replacement? Clin Orthop 1996;331:221.
    arthroplasty. Physiotherapy Singapore 1999;2:2.          28. Ware Jr JE, Kosinski M, Keller SD. A 12 item short
22. Norkin CC, Levangie PK. Joint structure and func-            form health survey: construction of scales and
    tion. 2nd ed. Philadelphia: F Davis Company; 1992.           preliminary tests of reliability and validity. Med Care
23. Jordan LR, Siegel JL, Olivo JL. Early flexion routine:       1996;34:220.
    an alternative method of continuous passive motion.      29. Insall JN, Dorr LD, Scott RD, et al. Rationale of the
    Clin Orthop 1995;315:231.                                    knee society clinical rating system. Clin Orthop
24. MacDonald SJ, Bourne RB, Rorabeck CH, et al.                 1989;248:13.
    Prospective randomized clinical trial of continuous      30. Harvey IA, Barry K, Kirby SPJ, et al. Factors affecting
    passive motion after total knee arthroplasty. Clin           the range of movement of total knee arthroplasty.
    Orthop 2000;380:30.                                          J Bone Joint Surg Br 1993;75B:950.

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A comparison of 2 cpm protocols after total knee arthroplasty

  • 1. The Journal of Arthroplasty Vol. 20 No. 2 2005 A Comparison of 2 Continuous Passive Motion Protocols After Total Knee Arthroplasty A Controlled and Randomized Study Lisa A. Bennett, BAppSc, MPhty,* Sara C. Brearley, BAppSc,y John A. L. Hart, MBBS, FRACS, FA, Orth A, FASMF, FACSP,z and Michael J. Bailey, BSc, MSc§ Abstract: Effect of continuous passive motion (CPM) protocols on outcomes after total knee arthroplasty. In this prospective randomized controlled study, 147 patients were assigned to 1 of 3 treatment groups: CPM from 08 to 408 and increased by 108 per day, CPM from 908 to 508 (early flexion) and gradually progressed into full extension over a 3-day period, and a no-CPM group. The CPM was administered twice a day for 3 hours over a 5-day period. All patients participated in the same postoperative physiotherapy program. Patients were assessed preoperatively, day 5, 3 months, and 1 year postoperatively. The early flexion group had significantly more range of flexion than both the standard and control groups at day 5. There was no significant difference between the groups for any other variable tested at any time frame. Key words: total knee arthroplasty, CPM, rehabilitation, outcomes. n 2005 Elsevier Inc. All rights reserved. Continuous passive motion (CPM) can be applied to tion was detrimental to joints, motion was benefi- the knee joint by a mechanical device that moves cial, and CPM minimized forces across damaged through a preset range of motion (ROM) at a joint surfaces. For motion to be continuous, it has to selected velocity. Salter [1-3] researched and devel- be applied passively, as muscles would fatigue with oped the concept of CPM after experiments in rabbits continuous active movement of a joint [1-3]. where he demonstrated that articular cartilage Continuous passive motion devices have been defects and intra-articular fractures healed better widely used as an adjunct to physiotherapy after when CPM was used. He believed that immobiliza- total knee arthroplasty (TKA) for the past 2 decades [4]; however, there is controversy as to whether it is useful. Numerous studies have been From the *Department of Physiotherapy, The Alfred, Melbourne, carried out on the effects of CPM after TKA. Australia; yDepartment of Physiotherapy, Caulfield General Medical Parameters such as knee ROM, length of stay Centre, Melbourne, Australia; zDepartment of Surgery, The Alfred, Monash University, Melbourne, Australia, and §Department of (LOS), wound healing, and knee function have Epidemiology and Preventative Medicine, Monash University, Australia. been evaluated with contradictory results. Some Submitted October 27, 2003; accepted August 9, 2004. [4-12] recommend CPM, whereas others [13-18] Benefits or funds were received in partial or total support of the research material described in this article from the Alfred, have found it to be of little value in rehabilitation of Melbourne, Australia (small projects grant). the knee after TKA. The differences in outcomes can Reprint requests: (From 15 October 2004 to 15 October 2005) be explained partly by variations in study design and Sara C Brearley, Physiotherapy Rehabilitation Department, Caulfield 3162, Victoria, Australia. (From 16 October 2005) Lisa methodology. Differences in the duration of appli- Bennett, Physiotherapy Department, The Alfred, Commercial cation of CPM ranging from as little as 4 hours a day Road, Prahran 3182, Australia. [15] to almost 24 hours per day [19] have been n 2005 Elsevier Inc. All rights reserved. 0883-5403/04/2002-0013$30.00/0 reported. Some studies [13,15,19-21] have included doi:10.1016/j.arth.2004.08.009 small samples, which may affect validity. 225
  • 2. 226 The Journal of Arthroplasty Vol. 20 No. 2 February 2005 The primary motions of the knee joint are flexion flexion and 08 extension of the knee, decreasing and extension [22]. Traditionally, CPM has been LOS, and improving knee function. administered by moving the knee from full exten- 2. There would be no difference in wound healing sion through increasing degrees of flexion [19]. For between the 3 groups. the purposes of this paper, we refer to this method as standard CPM. More recently, an early flexion Materials and Methods regime has been advocated in which the knee is progressively moved from flexion to extension Study Design [21,23-25]. Jordan et al [23] conducted a non- randomized trial comparing standard and early Patients were allocated by a block randomization flexion CPM after primary TKA. Early flexion procedure into 1 of 3 groups: resulted in decreased LOS, decreased hospital costs, and increased ROM at 1 year. On the other hand, ! Group A: Standard CPM regime MacDonald et al [24] found no statistical differences, ! Group B: Early flexion CPM regime at any measured interval, between standard and ! Group C: No CPM (the control group). early flexion CPM regimes and a no-CPM group. The operating surgeon and the independent Their randomized trial evaluated cumulative anal- assessor were blinded to the group allocation of the gesic requirements, ROM, LOS, and Knee Society subjects, and the subjects were blinded to the study scores. The authors acknowledge, however, that a hypotheses. To determine the number of subjects longer trial of CPM may have benefited these required to achieve statistical significance, a power patients as CPM was only utilized for a maximum analysis was performed. The sample size was based of 24 hours postoperatively. Our study is the first on 3 pairwise comparisons of the groups each at a prospective randomized controlled trial comparing 2 significance level of 1.7% (=5%/3) at 5 days after CPM protocols where the CPM has been adminis- operation. To detect a difference of 78 knee ROM tered over a significant period of time. between groups with an SD of 108 within each group, the study needed to recruit 43 subjects per Aims of The Study group to achieve 80% power. It is generally accepted that goniometric measurements of the knee have an The aims of the research were to assess error rate of F58 [26]. If a 78 ROM difference existed in our study, this would represent a true difference 1. The effect of CPM after TKA on knee ROM, between the groups A, B, and C rather than a length of hospital stay, wound healing, knee difference due to measurement error. function, and perceived health status. 2. Whether early flexion CPM produces a better Study Cohort outcome than a standard CPM regime or control with no CPM. One hundred forty-eight patients were initially recruited into the study. One patient was subse- Hypotheses quently excluded from the study, as we were unable to achieve 908 knee flexion on the CPM 1. Early flexion CPM would be more effective than device in recovery. Results were analyzed for the standard CPM and no CPM in achieving 908 remaining 147 patients. They were admitted to The Table 1. Demographic Information A B C Group (Standard CPM) (Early flexion CPM) (No CPM) Total Patients (N) 47 48 52 147 Gender (% female) 72.3 64.6 67.3 Mean age (y) 70.7 71.4 71.7 Genesis I prosthesis (N) 7 5 7 19 Genesis II prosthesis (N) 40 43 45 128 Cruciate retained (N) 43 41 46 130 Posterior stabilized (N) 4 7 6 17 Patella resurfaced (N) 22 24 28 74 Patella not resurfaced (N) 25 24 24 73
  • 3. Continuous Passive Motion Protocols After Total Knee Arthroplasty ! Bennett et al 227 Table 2. Physiotherapy Program prostheses were again used at the discretion of the operating surgeon (Table 1). The patella was not Commencing day 1 postoperatively Ankle dorsi flexion/plantar flexion routinely resurfaced, at the discretion of the treat- Static quadriceps progressing to quadriceps over a fulcrum ing surgeon (Table 1). (active-assisted to active) Two Redivac drains were inserted and later Static gluteals Gentle active/active-assisted hip knee flexion on a removed at 48 hours. An attempt was made to powder board standardize the anesthetic protocol, but because of Chest care as indicated individual patient requirements this was not On day 2 possible. There was no significant difference be- Exercises as above progressing to independent straight leg raise tween the groups A, B, and C according to Transfer out of bed and sit out of bed in a chair if tolerated anesthetic techniques. On day 3 Exercises as above Physiotherapy Program Knee flexion over the side of the bed Ambulation with gait aids, full weight bearing initiated All patients participated in a standardized phys- iotherapy program (Table 2). Day 4 onward Knee flexion and extension ROM and strength, gait reeducation, and steps practiced. Patients with a quadriceps lag greater than 108 ambulated with CPM Protocols EKS until adequate knee control obtained Program conducted half an hour twice a day Group A: Standard except on weekends when patients were seen once a day Day 1 (operative day): CPM machine applied in the recovery room set at 08 to 408 for 3 hours. The CPM was removed and extension knee splint (EKS) ap- Alfred, Melbourne, between January 1997 and July plied to maintain the knee in extension overnight. 2000 for surgery using a Genesis I or II prosthesis Day 2: CPM machine applied early in the (Smith and Nephew, Memphis, Tenn). All had a morning at 08 to 458 for 3 hours and reapplied late primary diagnosis of osteoarthritis. Those excluded afternoon at 08 to 508 for 3 hours. Extension knee had bilateral TKA performed at the same time, splint applied overnight. revision of TKA, rheumatoid arthritis, or hemophil- Days 3 to 6: CPM increased 58 twice a day until ia. Demographic information is described in Table 1. ceased on day 6. Extension knee splint applied overnight. Surgical Procedure Group B: Early Flexion Initially, Genesis I TKA prostheses were used exclusively in the study, but this protocol changed Day 1 (operative day): CPM machine was applied to Genesis II when the prosthesis became available. in the recovery room at 908 to 508 knee flexion. Ten experienced surgeons working in 2 surgical The CPM machine was cycled between 908 and 508 units at The Alfred performed the operations. flexion for 3 hours. Knee rested at 908 flexion on Trainee registrars supervised by the senior surgeons the machine overnight. performed some procedures. An anteromedial or Day 2: CPM between 908 and 408 for 3 hours. midline incision was used, and the knees were Continuous passive motion was turned off but approached through a medial parapatellar capsular remained in situ with the knee resting in 908 flexion incision. Cruciate retaining and posterior-stabilized on the machine. Continuous passive motion applied Table 3. Mean Knee Flexion CPM Group A (Standard) B (Early Flexion) C (None) Knee ROM Active Flexion Passive Flexion Active Flexion Passive Flexion Active Flexion Passive Flexion Time Preoperative 102.58 108.38 102.58 108.68 102.68 108.88 Day 5 69.48 75.38 78.78 86.68 64.98 71.28 3 mo 95.08 95.88 93.78 1y 102.78 102.58 102.98
  • 4. 228 The Journal of Arthroplasty Vol. 20 No. 2 February 2005 Table 4. Mean Passive Knee Extension (Fixed Flexion Deformity) and Quadriceps Lag CPM Group A (Standard) B (Early Flexion ) C (None) Knee ROM Quadriceps Lag Passive Extension Quadriceps Lag Passive Extension Quadriceps Lag Passive Extension Time Preoperative 2.08 9.38 2.28 9.78 1.88 10.08 Day 5 12.18 6.28 11.68 7.78 12.98 6.58 3 mo 2.38 7.28 3.28 8.78 1.68 6.48 1y 1.08 3.68 1.58 3.48 0.18 4.18 late afternoon at 908 and 308 flexion for 3 hours, Analgesic requirements were not controlled in and the knee was rested in 908 flexion overnight. this study. If one patient group experienced Day 3: CPM between 908 and 208 for 3 hours in significantly more pain than the others, this could the morning and between 908 and 108 for 3 hours influence postoperative recovery and, hence, have in the afternoon. The CPM was then removed and an impact on the results. However, a specialized EKS applied overnight. pain team monitored these patients postoperative- Day 4: CPM between 908 and 08 for 3 hours in ly, and pain levels were recorded using a visual the morning and afternoon. The CPM was removed analogue scale twice a day when the machine was and the EKS applied overnight. not cycling, for the first five postoperative days. Days 5 to 6: CPM between 908 and 08 for 3 hours in the morning and afternoon. Extension knee Data Analysis splint in bed at night. Continuous passive motion ceased at the end of day 6. Means and standard errors were computed for each group at each time point (baseline, 5 days, 3 Group C: No CPM months, 1 year). Univariate analysis was conducted EKS in theater and remained in situ when in bed using v 2 tests for categorical variables and analysis of overnight and removed during the day. The patient variance for continuous normally distributed data. received no CPM. Where data were found to be log-normally distrib- uted (LOS, passive extension, and quadriceps lag), a log transformation was performed before analysis. Measurements Multivariate analysis was conducted using a repeat measures analysis of covariance adjusting for base- Data were collected from each patient in the line prognostic factors. Wound healing and perio- preoperative period (at a preadmission clinic) and perative anesthetic requirements were evaluated postoperatively at 3 months and 1 year. using v 2 tests for equal proportion. Perceived health 1. Knee flexion, extension, and quadriceps lag status, measured on an ordinal scale, was evaluated were measured in degrees with a standard using nonparametric analysis. universal goniometer [26]. These measurements were also taken on the fifth postoperative day. Results 2. Knee function was assessed using the functional component of the Knee Society Clinical Rating Range of Motion System [27]. 3. Perceived health status of each patient was Preoperatively, there were no statistically signif- assessed using the Short-Form 12-Item Health icant differences between the 3 groups in mean Survey (SF-12) [28]. On the fifth postoperative day, wound healing was evaluated using the following classification system: Table 5. Length of Hospital Stay (Acute) in Days aseptic wound discharge, aseptic wound dehiscence, Group N Geometric Mean LOS superficial infection, or deep infection [8]. Wound healing was considered to have failed if there was A (Standard CPM) 47 8.8 infection or aseptic dehiscence of the wound. B (Early flexion CPM) 48 8.1 C (No CPM) 52 8 Hospital (inpatient) LOS was recorded in days in P .51 the acute and rehabilitation settings.
  • 5. Continuous Passive Motion Protocols After Total Knee Arthroplasty ! Bennett et al 229 Table 6. Length of Hospital Stay (Rehabilitation) Table 8. Wound Healing in Days Wound Healing Group N Geometric Mean LOS (5th Postoperative Day) Yes (N) No (N) A (Standard CPM) 32 18.7 A (Standard CPM) 93.5% 43 6.5% 3 B (Early flexion CPM) 29 17.8 B (Early flexion CPM) 98% 47 2% 1 C (No CPM) 39 15.8 C (No CPM) 92.3% 48 7.7% 4 P .58 P .44 passive or active flexion (Table 3), or in quadri- Pain ceps lag or passive extension (Table 4). At day 5 postoperatively, there were significant differ- The mean of the 10 visual analogue scale scores ences between the groups in active flexion for each patient was calculated; hence, a score out ( P = .008 and P b .0001) and passive flexion of 10 was determined. There are statistically ( P = .007 and P b .0001) (Table 3). At 3 months significant differences in mean pain scores between and 1 year postoperatively, there were no signif- groups A and B ( P b .0001), groups B and C ( P = icant differences between the groups in active .005), and groups A and C ( P = .013) (see Table 7). flexion, passive extension, and quadriceps lag. These differences are, however, not clinically (Tables 3 and 4). significant as they represent less than or equal to 1 point on a 10-point scale. Length of Stay Wound Healing Patients were discharged home when the mul- tidisciplinary team assessed them as being able to Healing rates for the groups are represented in manage safely in their home environment. Some Table 8. A v 2 analysis revealed that there was no patients were transferred to a rehabilitation significant difference between the groups in wound facility for ongoing therapy before discharge. healing rates ( P = .44). Length of acute hospital stay (in days) for the 3 groups was 8.8 for group A, 8.1 for group B, Knee Function and 8.0 for group C. There was no significant Knee function was assessed using the Knee difference between the groups ( P = .51) (Table 5). Society Clinical Rating System [29]. There was One hundred patients went to a rehabilitation no significant difference between the 3 groups facility. Of these, 32 were in group A (geometric preoperatively, at 3 months or at 1 year (Table 9). mean LOS = 18.7 days), 29 were in group B (geometric mean LOS =17.8 days), and 39 were in Perceived Health Status Measure SF-12 group C (geometric mean LOS =15.8 days). There was no significant difference between the groups The SF-12 is a shorter version of the SF-36 ( P = .58) (Table 6). used to reproduce its Physical Component Sum- mary (PCS) and Mental Component Summary (MCS) scores [28]. There was no significant difference between the groups in PCS and MCS preoperatively, nor at 3 months and 1 year postoperatively. Table 7. Visual Analogue Scale Scores Mean Score Over Group Day 1 Day 2 Day 3 Day 4 Day 5 5 days Table 9. Knee Society Scores: Function A (Standard 4.1 3.7 3.5 3.4 3.2 3.6 (Means and SEs) CPM) B (Early 3.2 2.9 2.5 2.3 2.4 2.6 CPM group A B C flexion CPM) Preoperative 40.1 (3.0) 42.1 (3.0) 45.3 (2.8) C (No CPM) 3.5 3.1 3.1 3.1 2.9 3.1 3 mo 51.9 (3.6) 52.2 (3.2) 56.0 (3.0) P b.0001 1y 57.9 (3.6) 59.6 (3.4) 58.1 (3.1)
  • 6. 230 The Journal of Arthroplasty Vol. 20 No. 2 February 2005 Discussion In contrast, Harms and Engstrom [4] found that CPM resulted in a significant improvement in knee Flexion: Early Postoperative Phase extension. In our study, we found no significant differences between the groups in passive knee The present study demonstrated a significant extension at 3 months nor at 1 year. Other authors improvement in active and passive knee flexion have reported the same finding [10,19,24,25]. at day 5 postoperatively in group B compared to groups A and C. McInnes et al [9] reported that Quadriceps Lag standard CPM significantly increased active flexion at 1 week postoperatively but not at 6 weeks. We found no significant differences between the Harms and Engstrom [4] found knee flexion was groups in quadriceps lag at day 5, 3 months, and 1 increased in a standard CPM group when compared year postoperatively. Other authors [23-25] did not with a no-CPM group. Yashar et al [25] found a examine quadriceps lag in their publications. Ng significant difference in passive knee flexion in and Yeo [21] found no significant differences favor of an early flexion group. Other studies have between groups in active extension on the fifth reported no significant differences [19-21]. postoperative day. Flexion: Late Postoperative Phase Length of Stay At 3 months and 1 year postoperatively, there There were no significant differences between was no significant difference between the groups in the groups in acute or rehabilitation hospital active or passive knee flexion in our study. This is inpatient LOS, which is in agreement with Yashar in agreement with the findings of other studies at et al [25] and MacDonald et al [24], but is in 3-, 6-, and 12-month evaluations [17,19,24,25]. In contrast to the findings of the nonrandomized contrast, Jordan et al [23] in a nonrandomized study on 100 TKA patients by Jordan et al [23]. study reported that an early flexion CPM regime The latter authors reported that the early flexion produced increased flexion ROM at 1 year com- resulted in decreased LOS and decreased hospital pared with standard CPM. costs and improved ROM at 1 year. Our acute The average active range of knee flexion in our hospital LOS for all groups was higher than that study, at 1 year postoperatively, was 1038 for all reported by MacDonald et al [24]. There are a groups. This value is lower than the 1128 average number of possible reasons for this including knee flexion reported by MacDonald et al [24] and patient demographics. MacDonald et al [24] ex- Yashar et al [25]. The likely explanation for this cluded patients older than 80 years and those who difference is that postoperative ROM is influenced were unable to ambulate 30 m and climb 10 steps. by preoperative ROM [30]. In our study, the patients In our study, age was not an exclusion criterion were all public hospital patients and mean preoper- and some of our patients were virtually wheelchair ative active flexion was 102.68 (Table 3). In a cohort bound before surgery because of a long waiting list. treated privately, the average preoperative flexion These are important factors in outcome. Further- was 111.58 and the postoperative flexion was 111.68. more, MacDonald et al [24] excluded patients if MacDonald et al [24] reported a mean preoperative they had fixed flexion deformities greater than 158, range of 1068, whereas Yashar et al [25] reported a whereas in our study 17 patients had deformities of mean preoperative ROM of 1108. The mean age of that magnitude. Thus, over 10% of our subjects patients in our study was 71 years. In the study of had severe degenerate disease of the knee preop- MacDonald et al [24], the mean age was not stated, eratively, which would have contributed to a but patients older than 80 years were excluded, as slower recovery. Johnson [7,8] found LOS was were those with a greater than 158 fixed flexion significantly reduced after the use of standard CPM deformity. In the study of Yashar et al [25], the mean compared with control. However, others [4,9] have age was 69 years. In our study, increased patient age found no significant difference in LOS between and stiffer knees preoperatively may have contrib- standard and control groups. Local discharge poli- uted to the reduced range of movement. cies and the availability of rehabilitation facilities also affect length of acute hospital stay. Extension Wound Healing We found no statistically significant differences between the groups in passive extension in the first Johnson [7] reported that transcutaneous oxy- postoperative week, as did previous authors [9,21]. gen tension on the lateral aspect of the incision
  • 7. Continuous Passive Motion Protocols After Total Knee Arthroplasty ! Bennett et al 231 decreased as the knee flexed past 408; hence, we preoperatively (Table 10). The reason for this is not were somewhat concerned about the risk of wound clear. The number of complications in the no-CPM breakdown in the early flexion group. In the group was not significantly different when com- present study, the early flexion group knees were pared to the CPM groups at 3 months and 1 year. maintained in 908 flexion overnight for 2 nights, Adequate test-retest reliability using the SF-12 was but there were no significant differences between demonstrated by Ware et al [28]: PCS = 0.89 and the groups in wound healing when assessed on the MCS = 0.76. This measurement tool was designed fifth postoperative day, which agrees with Yashar et for large group studies with patient populations al [25]. Our early flexion group had fewer wound greater than 500 [28]. Therefore, it may not be the complications than the control or standard groups most reliable tool to estimate perceived health (Table 8). Ververeli et al [12] also found that there status in clinical applications such as the present was no significant difference in wound healing study. between standard and no-CPM groups. Study Limitations and Suggestions Knee Function for Future Research The functional component of the Knee Society Our patients attended a preadmission clinic Clinical Rating System [29] was used as a mea- where they received education, written informa- surement tool in this study. It demonstrates good tion about TKA, and a personalized exercise responsiveness when used to assess outcome after program to be commenced before their operation. TKA [27]. Despite a 5-point difference in preoper- Attendance at this clinic may have influenced the ative Knee Society function scores between control results in favor of the no-CPM group. Postopera- and standard CPM groups (Table 9), there were no tively patients were given 2 half-hour sessions of statistically significant group differences preopera- physiotherapy daily during the week and 1 half- tively. In addition, there were no statistically hour session on weekends. This intensive program significant differences at 3 months or 1 year is not readily available in all hospitals. The role of between control and CPM treatment groups. Sim- CPM in the early postoperative management of ilarly, MacDonald et al [24] also found that there patients who are medically or psychologically were no differences between the control and CPM impaired was not addressed in our study and may groups preoperatively and at 1 year when evaluat- require further investigation. Colwell and ed using the Knee Society scoring system. McInnes Morris [19] found that isolating outliers made the et al [9] reported no significant differences between LOS significantly different between a no-CPM standard CPM and control groups in knee function group and a standard CPM group. at 6 weeks after TKA. Statistical tests are for means and assess whether the means of different groups are statistically Perceived Health Status different. This conclusion fails to identify individ- uals or subgroups that may have benefited from the The Medical Outcomes Study SF-12 includes 12 intervention. Thirty-three of the 147 patients questions from the SF-36. No other authors evaluated in this study had a preexisting fixed evaluating the effects of CPM on TKA have used flexion deformity (FFD) of 158 or more. We the SF-12. In the present study, we found no dif- analyzed the day 5 postoperative results of these ferences in SF-12 scores preoperatively, at 3 patients for the purpose of generating ideas for months or at 1 year between the 3 groups. How- future research. Statistical analysis of this subgroup ever, the PCS for the control group was signifi- showed that these patients had statistically signif- cantly worse at 1 year postoperatively compared to icant increases in quadriceps lag ( P = .0005) and Table 10. SF-12 Scores (Means and SEs) Group A (Standard CPM) B (Early Flexion CPM) C (No CPM) SF-12 PCS MCS PCS MCS PC MCS Preoperative 38.0 (2.0) 48.1 (1.8) 42.2 (2.0) 45.7 (1.8) 43.4 (1.8) 44.5 (1.7) 3 mo 39.4 (2.3) 50.4 (2.1) 38.4 (2.1) 53.3 (1.9) 39.5 (1.9) 54.1 (1.8) 1y 43.8 (2.4) 54.3 (2.2) 40.0 (2.3) 54.4 (2.1) 37.8 (2.1) 54.3 (1.9)
  • 8. 232 The Journal of Arthroplasty Vol. 20 No. 2 February 2005 passive extension loss ( P b .0001) when compared an experimental investigation in the rabbit. J Bone to the rest of the group (patients with a FFD V108). Joint Surg 1980;62A:1232. We also analyzed the FFD subgroup according to 3. Salter RB: Motion vs rest: why immobilize joints? J CPM group allocation (A, B, C). There were no Bone Joint Surg 1982;64B:251. 4. Harms M, Engstrom B. Continuous passive motion as statistically significant differences in quadriceps lag an adjunct to treatment in the physiotherapy man- or passive extension loss between the groups. agement of the total knee arthroplasty patient. Unfortunately, the sample size was small and a Physiotherapy 1991;77:301. larger sample of patients with clinically significant 5. Coutts RD, Toth C, Kaita JH. The role of continuous preexisting FFD would need to be evaluated to passive motion in the rehabilitation of the total knee determine whether CPM makes a difference for patient. In Hungerford DS, Krackow K, Kenna RV, some patients after TKA. editors. Total knee arthroplasty: a comprehensive approach (p. 126). Baltimore: Williams & Wilkins; 1984. Conclusion 6. Coutts RD. Continuous passive motion in the reha- bilitation of the total knee patient: its role and effect. The results of this study show that an early Orthop Rev 1986;15:27. flexion CPM regime is useful in achieving a better 7. Johnson DP. The effect of continuous passive motion range of active and passive flexion in the early on wound healing and joint mobility after knee postoperative period after TKA, but did not result in arthroplasty. J Bone Joint Surg 1990;72A:421. decreased LOS. Length of stay is, however, multi- 8. Johnson DP, Eastwood DM. Beneficial effects of factorial and influenced by social issues in addition continuous passive motion after total condylar knee arthroplasty. Ann R Coll Surg Engl 1992;74:412. to joint function. We were unable to demonstrate 9. McInnes J, Larson MG, Daltroy LH, et al. A controlled any significant difference between standard and evaluation of continuous passive motion in patients early flexion CPM and control groups after dis- undergoing total knee arthroplasty. JAMA 1992; charge. There was no difference in wound healing 268:1423. rates, functional outcome, or perceived health 10. Maloney WJ, Schurman DJ, Hangen D, et al. The status. From these results, we have been unable influence of continuous passive motion on outcome to justify the use of CPM as a routine rehabilitation in total knee arthroplasty. Clin Orthop 1990;256:162. tool in the public hospital setting after TKA. The 11. Romness DW, Rand JA. The role of continuous role of CPM in the management of patients with passive motion following total knee arthroplasty. difficult problems or in facilities where manpower Clin Orthop 1988;226:34. is limited warrants further study. 12. Ververeli PA, Sutton DC, Hearn SL, et al. Continuous passive motion after total knee arthroplasty — analysis of costs and benefits. Clin Orthop 1995; 321:208. Acknowledgments 13. Chiarello CM, Gundersen MS, O’Halloran T. The effect of continuous passive motion duration and This research was supported by an Alfred increment on range of motion in total knee arthro- Hospital small project grant. The authors wish to plasty patients. J Orthop Sports Phys Ther 1997; acknowledge Helen Donaldson of Smith and 25:119. Nephew Surgical Pty Ltd for her extensive role in 14. Kumar PJ, McPherson EJ, Dorr LD, et al. Rehabili- data collection. We would also like to thank Lara tation after total knee arthroplasty — a comparison of Kimmel and members of the physiotherapy de- 2 rehabilitation techniques. Clin Orthop 1996; 331:93. partment at The Alfred for treating the patients, 15. Nielson PT, Rechnagel K, Nielsen SE. No effect of and the surgeons of the Department of Orthopedic continuous passive motion after arthroplasty of the Surgery for allowing their patients to participate in knee. Acta Orthop Scand 1988;59:580. the study. 16. Pope RO, Corcoran S, McCaul K, et al. Continuous passive motion after primary total knee arthro- plasty — does it offer any benefits? J Bone Joint Surg References Br 1997;79B:914. 17. Ritter MA, Gandolf VS, Holston KS. Continuous 1. Salter RB, Field P. The effects of continuous com- passive motion versus physical therapy in total knee pression on living articular cartilage: an experimental arthroplasty. Clin Orthop 1989;244:239. investigation. J Bone Joint Surg 1960;42A:31. 18. Nadler SF, Malanga GA, Zimmerman JR. Continuous 2. Salter RB, Simmonds DF, Malcolm BW, et al. The passive motion in the rehabilitation setting. A biological effect of continuous passive motion on the retrospective study. Am J Phys Med Rehabil 1993; healing of full-thickness defects in articular cartilage: 72:162.
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