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Breakthrough Innovation, Barcelona 2010




Innospire
The global innovation initiative
@ Merck
Dr. Ulrich Betz
Director, Head of Department
Center of Innovation
Merck Serono
Merck KGaA
Milestones in the history of Merck


Merck is the oldest pharmaceutical and chemical company in the
world
1668                                        1827
Friedrich Jacob Merck (1621-1678)           Heinrich Emanuel Merck (1794-1855)
buys the Angel Pharmacy (Engel-             starts production on an industrial scale
Apotheke)




                                    Innospire 2009                                     1
Merck is not the same as Merck


• Merck KGaA and the U.S. pharmaceutical company Merck & Co.
  have been two independent companies since 1917.

• Common historical roots:

    • 1891 Merck & Co. founded in New York by Georg Merck, a
      member of the Merck family

    • As a consequence of World War I, Merck & Co. was expropriated
      and became an independent company.

• Today, Merck & Co. holds the rights to the name within North
  America. Merck KGaA operates there as EMD and holds the rights
  to the name Merck in the rest of the world.


                               Innospire 2009                         2
Corporate structure


                     Merck Group
                    Business sectors
    Pharmaceuticals                                  Chemicals




                                                                           Divisions
     Merck Serono                                  Liquid Crystals

                                                     Performance &
  Consumer Health Care                            Life Science Chemicals



                      Central functions



                                 Innospire 2009                                        3
Merck Group
FY 2009 by division




                      Innospire 2009   4
Merger between traditional Pharma and Biotech
Opportunity to take the best of both worlds

  Merck Ethicals                                       Serono

    Division of Merck KGaA (family-owned since             Family-owned since 1906
    1668)
                                                           Major success with Rebif®, the leading multiple
    Major success with Erbitux® in developing a            sclerosis product outside the U.S.
    world-class Oncology franchise
                                                           Strategy of focusing on specialized therapeutic
    Successful CardioMetabolic Care franchise              areas for serious medical needs (fertility,
    built on core product families (Glucophage®,           metabolic endocrinology)
    Concor® and Euthyrox®)
                                                           Strong capabilities in developing biotech
                                                           compounds

                                  Founded 5th January 2007

                                  Focus on innovative small molecular and
                                  protein drugs

                                  Around 17000 employees

                                  € 4.993 billion sales in 2009

                                  Headquarter in Geneva, Switzerland
                                                   Innospire 2009                                            5
Reaching the next level




                 Innospire 2009   6
The 7 sources of innovation


                     The Innovator Mindset
          Company
 Line                          Collabo-                                 Open
            wide                                 Consul-
organi-              Scouts     ration                     Customers Innovation
            idea                                  tants
zation                         Partners                               platform
          sourcing
                     Evaluate
                        - market potential
                        - probability of success
                        - exploitability
                        - cross-divisional synergies
                      Enable operational phase
                          „fit for purpose“

                        New business
                                Innospire 2009                              7
To proudly go where nobody
dared to go before…




                    Innospire 2009   8
Or …to proudly go where nobody
dared to go before…




                   Innospire 2009   9
Mobilize Merck‘s full innovation potential
in challenging times



 Established processes



innospire
Involvement of all employees
    • Across organizational units
    • Across the hierarchy
    • Beyond existing businesses
Fostering entrepreneurial spirit
                                    Innospire 2009   10
Corporate structure


                     Merck Group
                    Business sectors
    Pharmaceuticals                                         Chemicals




                            synergies




                                                                                  Divisions
     Merck Serono                                         Liquid Crystals

                                                            Performance &
  Consumer Health Care                                   Life Science Chemicals



                      Central functions



                                        Innospire 2009                                        11
What is innospire ?



• innospire: The Chemical and Pharmaceutical divisions have jointly
  started a new worldwide process to source and develop ideas from all
  Merck employees
• innospire mobilizes Merck‘s full innovation potential in economically
  challenging times
• innospire created an environment for entrepreneurial individuals to form
  highly motivated professionally trained teams and move forward with
  innovative business ideas and professional business plans
• innospire especially welcomes ideas that benefit both chemical and
  pharmaceutical divisions
• innospire is complementary to the Merck Innovation Award, local
  suggestion schemes and the divisional R&D pipeline processes

                                  Innospire 2009                          12
The innospire Process –
Five phases towards global success

 Phase 1           Phase 2              Phase 3               Phase 4          Phase 5
       Idea            Idea               Innovation            Innovation         Enabling
     Sourcing        Selection              Market-             Bootcamp           Projects
                                             place

     Kick-off           462                 17                      6     Grand
     March 30        submissions      business concepts          projects Jury

      April         May            June                        Oct           Dec        2010


Three key differences to „classic“ idea competitions:
1)     Idea matures and evolves
       (the idea put in does not need to be identical to the idea that comes out of the bootcamp)
2)     Team matures and evolves
       (it can be different people that propose the idea, that mature the idea to business case
        and that finally implement it, teams get training and consulting to overcome hurdles)
3)     Self-assembling teams, survival of the fittest
       (only those ideas survive that manage to convince a team to work on them)
                                           Innospire 2009                                     13
innospire - Call for Ideas




                        Innospire 2009   14
innospire.merck.de




                     Innospire 2009   15
Thank you!


  Innospire has received
     462 submissions
from 550 idea champions
    out of 32 countries

          Innospire 2009   16
Total Number of Entries   Entries by Date




                                            Date
                                            Innospire 2009   17
Number of Entries




                                                                                                     100
                                                                                                           120
                                                                                                                 140
                                                                                                                       160




                                                                           20
                                                                                40
                                                                                      60
                                                                                                80




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                                                                                                                             Entries by Countries




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Innospire 2009
                                                                   1
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                                                                   1




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                                         Ki
                                                                   4




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                                                     do
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                                                  U
                                      Ve SA
                                           ne
                                                                                           60




                                                 zu
                                                       el
                                         Vi               a
                                                                   2




                                              et
                                                   na
                                                        m
                                                                   1




18
Entries by targeted Business Sector




               22%
                                      Pharma Entries
       45%                            Chemicals Entries
                                      Pharma+Chemicals Entries
              33%




                     Innospire 2009                              19
Entries by Idea Type




        16%
                21%                     Application Entries
                                        Material Entries
     22%                                Process Entries

              41%                       Service Entries




                       Innospire 2009                         20
The innospire process –
Phase 2: Idea Selection

                       1st set of Criteria                     2nd set of Criteria
    Phase 2          • Suitability for further optimization   • Prioritization of joint Chemical
                       to a full business plan                  & Pharma ideas
        Idea
      Selection      • Market attractiveness,
                       potential revenue                      • Balance Blue Sky (long term)
                                                                ideas, medium-term ideas,
     462 ideas       • Industry attractiveness,                 and Quick Wins (fast sales
                       competitive situation                    generators)
                     • Risk profile, proof of concept
                                                              • Balance ideas with a focus
                       feasibility
                                                                on materials, technologies,
  17 member          • Breakthrough vs.                         applications and new
 cross-functional      incremental innovation                   business models
 evaluation team
                     • Synergies with existing business


                                                                    Re-            Evaluation
Pre-assessment      Evaluation          40 interviews            evaluation
      with                                                                         by 2nd set
                    by 1st set            with idea              by 1st set        of criteria
  scorecards        of criteria                                  of criteria
                                           owners

                                           Innospire 2009                                        21
The innospire process –
Phase 3: Innovation Marketplace




                                              Phase 3
                                        Objectives and Criteria


 The Objectives of this Phase                    Criteria for next Phase 4
• First presentation of idea on marketplace    • Refined business concept
  events                                       • Are the different roles, e.g. champion, finance,
• Recruitment of bootcamp teams                  marketing/sales, present in the team?
• Creative entrepreneurial colleagues can      • Is there a clear leader?
  apply to join a team.                        • Do the team members have a consistent vision?
• Refinement of business concepts              • Are the team members very committed?

                                               Innospire 2009                                       22
Innovation Market Place


• Presentation of 17 business concepts




 - Market Place Kick-off event
 - Poster sessions at key locations including Darmstadt, Geneva and Boston
 - Date: June 2009

 - Presentation by Poster, Powerpoint, or Video
 - Intranet portal for global coverage

• Recruitment of bootcamp teams and refinement of
  business concepts
                                             Innospire 2009                  23
Innovation Bootcamp


The innovation bootcamp has the objective
to nurture and coach early stage ideas in
Merck, to advance in the company and to
become successful businesses

Modules
- Teaching - Coaching - Writing - Fun

Content
- Case studies                   - Basic theory                   - Presentation skills
- Marketing plan                 - Market Forecasting             - Manufacturing issues
- Financial plan                 - Legal issues                   - Team building
- Integration plan               - Launching plan

Faculties
Prof. Stefan Stremersch, Chair of Economics and Chair of Marketing at Erasmus University Rotterdam
Prof. Dr. Walter Van Dyck, Professor of Technology and Innovation Management, Tilburg University
Dr. Guido Petit, Director of Alcatel-Lucent Technical Academy
Merck internal experts on manufacturing, patent, financial, integration issues and HR
                                           Innospire 2009                                       24
Teams are inspired and innovative




     I need innospire because                                I need innospire because
 It gives a chance to make cross-divisional             It adds a lot to the fun I have at my job and
     ideas real, that have no home in the               makes Merck a more attractive employer. It
                 business units                             is a great opportunity to broaden my
   and would not have a chance otherwise                          expertise and knowledge.
                                       Innospire 2009                                          25
Statements from innospire
bootcamp participants


I need innospire because
  – It gives a chance to make cross-divisional ideas real, that have no
    home in the business units and would not have a chance otherwise
  – It gives us the possibility to think of innovations by combining
    different divisions expertise
  – The process brings ideas to reality
  – It encourages Merck employees to use their own creativity for the
    good of the company
  – It adds a lot to the fun I have at my job and makes Merck a more
    attractive employer. It is a great opportunity to broaden my
    expertise and knowledge.

                                 Innospire 2009                         26
The Grand Jury

• Composed of members of the
  Executive Management Boards
  from Merck Chemicals Division
  and from Merck Serono
• 20min for each team leader
  to present the business plan
• 10min Q&A
• Selection of projects that are endorsed to move to the enabling
  phase
• Allocation of budget
• Debriefing of teams
• 5 of the 6 presented business plans were endorsed!
                                  Innospire 2009                    27
From idea to business


                                                                                   TAs/BUs
                                                                                   LC/PC/AT
                                                                                   Pipelines
                     direct
                     uptake


internal idea call
                                                later uptake
 innospire
                                                               formation of new
                                                                 business unit
                                    innovation
                     Innovation                                    spin off
                      incubator     incubator
                                                                   out-licensing

                                  mature with innovation funding
                                  Project selection and
                                     governance via
                                   Innovation Steering
                                       Committee
                                        Innospire 2009                                 28
Merck Innovation Steering
Committee

Members
• Head Porfolio Development Head Advanced Technologies
  Head R&D                  Head Performance Life Science
  Head Patents              Head Innovation Management

Mandate
• Fully exploit cross-divisional synergies
• Promote innovation @ Merck
• Align on innospire calls and other innovation initiatives
• Governance of cross-divisional incubator projects


                                       Innospire 2009         29
Two cross-divisional project teams are in the
enabling phase supported by innospire funds




                           Innospire 2009       30
Additional ideas will be followed-up
and qualified in 2010


       2009                  2010                        2011                2012
Idea
         Innovation
Call     Bootcamp              Project Enablement
2009




                    Idea
                 Follow-up     Innovation
                               Bootcamp                   Project Enablement
                 Workshops




                                                  Idea     Innovation
                                                  Call     Bootcamp     Project Enablement
                                                  2011


  2010: Focus on idea evaluation and maturation from 2009 call
      feedback to all idea submitters, new idea call in 2011
                                       Innospire 2009                                 31
innospire
A success story


• Highlighting the importance and the support for innovation
  at all times
• Fostering global inter-divisional collaboration
• Supporting innovative thinking and an entrepreneurial
  mindset
• Training, coaching and support for project teams
• 5 endorsed business plans on their way in highly
  motivated project teams to generate new business for
  Merck

                             Innospire 2009                    32
Thank you!       ulrich.betz@merck.de




Innospire 2009                          33

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Frt 110523.3A - Vision Meeting - Intrapeneurship - Alcatel-Lucent - Presentatie Lucent- Merck - Ulrich Betz - Barcelona

  • 1. Breakthrough Innovation, Barcelona 2010 Innospire The global innovation initiative @ Merck Dr. Ulrich Betz Director, Head of Department Center of Innovation Merck Serono Merck KGaA
  • 2. Milestones in the history of Merck Merck is the oldest pharmaceutical and chemical company in the world 1668 1827 Friedrich Jacob Merck (1621-1678) Heinrich Emanuel Merck (1794-1855) buys the Angel Pharmacy (Engel- starts production on an industrial scale Apotheke) Innospire 2009 1
  • 3. Merck is not the same as Merck • Merck KGaA and the U.S. pharmaceutical company Merck & Co. have been two independent companies since 1917. • Common historical roots: • 1891 Merck & Co. founded in New York by Georg Merck, a member of the Merck family • As a consequence of World War I, Merck & Co. was expropriated and became an independent company. • Today, Merck & Co. holds the rights to the name within North America. Merck KGaA operates there as EMD and holds the rights to the name Merck in the rest of the world. Innospire 2009 2
  • 4. Corporate structure Merck Group Business sectors Pharmaceuticals Chemicals Divisions Merck Serono Liquid Crystals Performance & Consumer Health Care Life Science Chemicals Central functions Innospire 2009 3
  • 5. Merck Group FY 2009 by division Innospire 2009 4
  • 6. Merger between traditional Pharma and Biotech Opportunity to take the best of both worlds Merck Ethicals Serono Division of Merck KGaA (family-owned since Family-owned since 1906 1668) Major success with Rebif®, the leading multiple Major success with Erbitux® in developing a sclerosis product outside the U.S. world-class Oncology franchise Strategy of focusing on specialized therapeutic Successful CardioMetabolic Care franchise areas for serious medical needs (fertility, built on core product families (Glucophage®, metabolic endocrinology) Concor® and Euthyrox®) Strong capabilities in developing biotech compounds Founded 5th January 2007 Focus on innovative small molecular and protein drugs Around 17000 employees € 4.993 billion sales in 2009 Headquarter in Geneva, Switzerland Innospire 2009 5
  • 7. Reaching the next level Innospire 2009 6
  • 8. The 7 sources of innovation The Innovator Mindset Company Line Collabo- Open wide Consul- organi- Scouts ration Customers Innovation idea tants zation Partners platform sourcing Evaluate - market potential - probability of success - exploitability - cross-divisional synergies Enable operational phase „fit for purpose“ New business Innospire 2009 7
  • 9. To proudly go where nobody dared to go before… Innospire 2009 8
  • 10. Or …to proudly go where nobody dared to go before… Innospire 2009 9
  • 11. Mobilize Merck‘s full innovation potential in challenging times Established processes innospire Involvement of all employees • Across organizational units • Across the hierarchy • Beyond existing businesses Fostering entrepreneurial spirit Innospire 2009 10
  • 12. Corporate structure Merck Group Business sectors Pharmaceuticals Chemicals synergies Divisions Merck Serono Liquid Crystals Performance & Consumer Health Care Life Science Chemicals Central functions Innospire 2009 11
  • 13. What is innospire ? • innospire: The Chemical and Pharmaceutical divisions have jointly started a new worldwide process to source and develop ideas from all Merck employees • innospire mobilizes Merck‘s full innovation potential in economically challenging times • innospire created an environment for entrepreneurial individuals to form highly motivated professionally trained teams and move forward with innovative business ideas and professional business plans • innospire especially welcomes ideas that benefit both chemical and pharmaceutical divisions • innospire is complementary to the Merck Innovation Award, local suggestion schemes and the divisional R&D pipeline processes Innospire 2009 12
  • 14. The innospire Process – Five phases towards global success Phase 1 Phase 2 Phase 3 Phase 4 Phase 5 Idea Idea Innovation Innovation Enabling Sourcing Selection Market- Bootcamp Projects place Kick-off 462 17 6 Grand March 30 submissions business concepts projects Jury April May June Oct Dec 2010 Three key differences to „classic“ idea competitions: 1) Idea matures and evolves (the idea put in does not need to be identical to the idea that comes out of the bootcamp) 2) Team matures and evolves (it can be different people that propose the idea, that mature the idea to business case and that finally implement it, teams get training and consulting to overcome hurdles) 3) Self-assembling teams, survival of the fittest (only those ideas survive that manage to convince a team to work on them) Innospire 2009 13
  • 15. innospire - Call for Ideas Innospire 2009 14
  • 16. innospire.merck.de Innospire 2009 15
  • 17. Thank you! Innospire has received 462 submissions from 550 idea champions out of 32 countries Innospire 2009 16
  • 18. Total Number of Entries Entries by Date Date Innospire 2009 17
  • 19. Number of Entries 100 120 140 160 20 40 60 80 0 Au st ra Be lia 3 lg iu m 1 Br az il 2 C hi C na ol 61 um bi a 5 Fr an G c 5 er e m an G y r 136 G eec ua e 3 te m al a 1 In In di do a 3 ne si a 1 Ire la nd 1 Ita ly 9 Ja pa M n 52 Entries by Countries N exi et he co 5 rla nd s 3 Pe Ph ru 3 illi pi ne Country s 9 Po la R nd u Innospire 2009 1 Sa ma ud nia i 1 So Ara bi ut h a 1 Ko re a 9 S Sw pa itz in 2 er la nd Ta 36 iw Th an U 16 ai ni la te d n 7 Ar Tu d ab rk U Em ey 1 ni i te d rate Ki 4 ng s do m 17 U Ve SA ne 60 zu el Vi a 2 et na m 1 18
  • 20. Entries by targeted Business Sector 22% Pharma Entries 45% Chemicals Entries Pharma+Chemicals Entries 33% Innospire 2009 19
  • 21. Entries by Idea Type 16% 21% Application Entries Material Entries 22% Process Entries 41% Service Entries Innospire 2009 20
  • 22. The innospire process – Phase 2: Idea Selection 1st set of Criteria 2nd set of Criteria Phase 2 • Suitability for further optimization • Prioritization of joint Chemical to a full business plan & Pharma ideas Idea Selection • Market attractiveness, potential revenue • Balance Blue Sky (long term) ideas, medium-term ideas, 462 ideas • Industry attractiveness, and Quick Wins (fast sales competitive situation generators) • Risk profile, proof of concept • Balance ideas with a focus feasibility on materials, technologies, 17 member • Breakthrough vs. applications and new cross-functional incremental innovation business models evaluation team • Synergies with existing business Re- Evaluation Pre-assessment Evaluation 40 interviews evaluation with by 2nd set by 1st set with idea by 1st set of criteria scorecards of criteria of criteria owners Innospire 2009 21
  • 23. The innospire process – Phase 3: Innovation Marketplace Phase 3 Objectives and Criteria The Objectives of this Phase Criteria for next Phase 4 • First presentation of idea on marketplace • Refined business concept events • Are the different roles, e.g. champion, finance, • Recruitment of bootcamp teams marketing/sales, present in the team? • Creative entrepreneurial colleagues can • Is there a clear leader? apply to join a team. • Do the team members have a consistent vision? • Refinement of business concepts • Are the team members very committed? Innospire 2009 22
  • 24. Innovation Market Place • Presentation of 17 business concepts - Market Place Kick-off event - Poster sessions at key locations including Darmstadt, Geneva and Boston - Date: June 2009 - Presentation by Poster, Powerpoint, or Video - Intranet portal for global coverage • Recruitment of bootcamp teams and refinement of business concepts Innospire 2009 23
  • 25. Innovation Bootcamp The innovation bootcamp has the objective to nurture and coach early stage ideas in Merck, to advance in the company and to become successful businesses Modules - Teaching - Coaching - Writing - Fun Content - Case studies - Basic theory - Presentation skills - Marketing plan - Market Forecasting - Manufacturing issues - Financial plan - Legal issues - Team building - Integration plan - Launching plan Faculties Prof. Stefan Stremersch, Chair of Economics and Chair of Marketing at Erasmus University Rotterdam Prof. Dr. Walter Van Dyck, Professor of Technology and Innovation Management, Tilburg University Dr. Guido Petit, Director of Alcatel-Lucent Technical Academy Merck internal experts on manufacturing, patent, financial, integration issues and HR Innospire 2009 24
  • 26. Teams are inspired and innovative I need innospire because I need innospire because It gives a chance to make cross-divisional It adds a lot to the fun I have at my job and ideas real, that have no home in the makes Merck a more attractive employer. It business units is a great opportunity to broaden my and would not have a chance otherwise expertise and knowledge. Innospire 2009 25
  • 27. Statements from innospire bootcamp participants I need innospire because – It gives a chance to make cross-divisional ideas real, that have no home in the business units and would not have a chance otherwise – It gives us the possibility to think of innovations by combining different divisions expertise – The process brings ideas to reality – It encourages Merck employees to use their own creativity for the good of the company – It adds a lot to the fun I have at my job and makes Merck a more attractive employer. It is a great opportunity to broaden my expertise and knowledge. Innospire 2009 26
  • 28. The Grand Jury • Composed of members of the Executive Management Boards from Merck Chemicals Division and from Merck Serono • 20min for each team leader to present the business plan • 10min Q&A • Selection of projects that are endorsed to move to the enabling phase • Allocation of budget • Debriefing of teams • 5 of the 6 presented business plans were endorsed! Innospire 2009 27
  • 29. From idea to business TAs/BUs LC/PC/AT Pipelines direct uptake internal idea call later uptake innospire formation of new business unit innovation Innovation spin off incubator incubator out-licensing mature with innovation funding Project selection and governance via Innovation Steering Committee Innospire 2009 28
  • 30. Merck Innovation Steering Committee Members • Head Porfolio Development Head Advanced Technologies Head R&D Head Performance Life Science Head Patents Head Innovation Management Mandate • Fully exploit cross-divisional synergies • Promote innovation @ Merck • Align on innospire calls and other innovation initiatives • Governance of cross-divisional incubator projects Innospire 2009 29
  • 31. Two cross-divisional project teams are in the enabling phase supported by innospire funds Innospire 2009 30
  • 32. Additional ideas will be followed-up and qualified in 2010 2009 2010 2011 2012 Idea Innovation Call Bootcamp Project Enablement 2009 Idea Follow-up Innovation Bootcamp Project Enablement Workshops Idea Innovation Call Bootcamp Project Enablement 2011 2010: Focus on idea evaluation and maturation from 2009 call feedback to all idea submitters, new idea call in 2011 Innospire 2009 31
  • 33. innospire A success story • Highlighting the importance and the support for innovation at all times • Fostering global inter-divisional collaboration • Supporting innovative thinking and an entrepreneurial mindset • Training, coaching and support for project teams • 5 endorsed business plans on their way in highly motivated project teams to generate new business for Merck Innospire 2009 32
  • 34. Thank you! ulrich.betz@merck.de Innospire 2009 33