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Clinical Pharmacological Issues in the Elderly Charles A. Cefalu MD, M Professor and Chief, Section of Geriatric Medicine Department of Fam. Med, LSUHSC, New Orleans, La.
Evaluation for Possible Polypharmacy ,[object Object],[object Object],[object Object]
Increased Medication Use and Perceived Health in the Oldest Old ,[object Object],[object Object],[object Object]
Factors Related to Adverse Drug Drug Reactions ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Factors Related to Increased Number of Adverse Drug Reactions, Cont’d ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Normal Changes of Aging ,[object Object],[object Object],[object Object],[object Object],[object Object]
Normal Physiological Changes of the Organ Systems ,[object Object],[object Object],[object Object],[object Object]
Normal Changes of Aging-Hepatic ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Pharmaceutical Agents That Require Hepatic Metabolism ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Pharmaceutical Agents That Require Hepatic Metabolism ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
The Cytochrome System ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Particular Agents of Concern in the Elderly-highly bound to protein ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Normal Changes of Aging-Renal ,[object Object],[object Object],[object Object]
Creatinine Clearance Calculation ,[object Object],[object Object],[object Object],[object Object],[object Object]
Pharmaceutical Agents Primarily Eliminated In the Kidneys Requiring Dosage Adjustment ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Inappropriate Prescribing of Renally Excreted Agents in LTC ,[object Object],[object Object],[object Object]
Aminoglycoside Dosing in the Elderly With Impaired Renal Function ,[object Object],[object Object]
“Good Rule of Thumb” ,[object Object]
Physiological changes of the GI Tract ,[object Object],[object Object],[object Object]
CNS Changes with Aging ,[object Object],[object Object],[object Object],[object Object]
Anticholinergic Agents ,[object Object],[object Object],[object Object],[object Object]
Anti-cholinergic Agents-continued ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Common Clinical Conditions Necessitate Adjustment of Dosage in the Elderly: ,[object Object],[object Object],[object Object],[object Object],[object Object]
Anorexia and Aging ,[object Object],[object Object],[object Object]
Anorexia-Drug Induced: ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Specific High Risk Drug Categories
Screening for potential toxicity of prescription drugs-H2 Blockers: ,[object Object],[object Object],[object Object],[object Object]
H2 Blockers-continued ,[object Object],[object Object]
High Risk Drugs-Beta Blockers ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],.
Beta Blockers-continued ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Antihypertensives that cause Postural Hypotension or Sedation: ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Diuretics ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Diuretics-continued ,[object Object],[object Object],[object Object],[object Object]
Diuretics-References ,[object Object],[object Object],[object Object],[object Object]
Major and Minor Tranquilizers* and Hypnotics: ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Oral Hypoglycemics: ,[object Object],[object Object]
Lanoxin ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
NSAIDs*: ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
“ Tips” for Safe Traditional NSAID Use ,[object Object],[object Object],[object Object],[object Object],[object Object]
Narcotics: ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Theophylline Adverse Reactions: ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Oxybutynin ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Muscle Relaxers: ,[object Object],[object Object],[object Object],[object Object],[object Object]
Ophthalmologic Preparations ,[object Object],[object Object]
List Of Inappropriate Drugs In Elderly-Journal of American Medical Association-July 27, 1994; Archives of Internal Medicine-July 28, 1997 and 2003
Inappropriate Drugs in Elderly: ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Inappropriate Drugs in Elderly-Cont,d ,[object Object],[object Object],[object Object],[object Object]
Inappropriate Drugs in Elderly-Cont,d ,[object Object],[object Object],[object Object],[object Object],[object Object]
Inappropriate Drugs in Elderly-Cont,d ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Inappropriate Drugs in Elderly-Cont,d ,[object Object],[object Object],[object Object],[object Object],[object Object]
Inappropriate Drugs in Elderly-Cont,d ,[object Object],[object Object],[object Object],[object Object]
Pain Pill Use by Elders ,[object Object],[object Object]
Inappropriate Drugs in Elderly-Cont,d ,[object Object],[object Object],[object Object],[object Object]
Inappropriate Drugs in Elderly-Cont,d ,[object Object],[object Object],[object Object],[object Object],[object Object]
Inappropriate Drugs in Elderly-Cont,d ,[object Object]
Screening for Toxicity of OTC Drugs ,[object Object],[object Object],[object Object]
Screening for Toxicity-OTC Drugs-Cont. ,[object Object],[object Object],[object Object]
Rules for Prescribing to the Elderly ,[object Object],[object Object],[object Object],[object Object]
Rules, cont’d ,[object Object],[object Object],[object Object],[object Object],[object Object]
Rules, cont’d ,[object Object],[object Object],[object Object],[object Object]
 

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Geriatric%20 Medicine%20 %20 Dr.%20 Cefalu

  • 1. Clinical Pharmacological Issues in the Elderly Charles A. Cefalu MD, M Professor and Chief, Section of Geriatric Medicine Department of Fam. Med, LSUHSC, New Orleans, La.
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  • 45. List Of Inappropriate Drugs In Elderly-Journal of American Medical Association-July 27, 1994; Archives of Internal Medicine-July 28, 1997 and 2003
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