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Ceorins

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Flavio Guzmán
Flavio Guzmán
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Pharmacology of Cephalosporins: General Overview Flavio Guzmán, M.D. http://pharmamotion.com.ar
β - lactams: cell wall inhibitors
β -lactam ring ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Cell wall inhibitors: important features ,[object Object],[object Object],[object Object]
Mechanism of action 1 ,[object Object],[object Object],[object Object]
Mechanism of action 2
Cephalosporins
Cephalosporins: characteristics
Chemical structure of cephalosporins ,[object Object],[object Object]
First gen. cephalosporins.:
1st Generation cephalosporins: antibacterial coverage Active mainly against Gram positive cocci. Less active against Gram negative.
Clinical uses of first gen. cephalosporins
2nd generation cephalosporins
2nd generation cephalosporins. Antibiotic coverage ,[object Object]
3rd generation cephalosporins
3rd generation cephalosporins Coverage Increased coverage against Gram negatives. Decreased coverage against Gram +
3rd generation cephalosporins Clinical uses
Ceftriaxone and meningitis
4th generation cephalosporins
4th generation cephalosporins Antibacterial coverage Coverage against Gram + and Gram -, good activity against β -lactamase producing bacteria.
[object Object]

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  1. or instance, certain antibiotics, like beta-lactams (penicillins, cephalosporins, carbapenems, monobactams), clindamycin, macrolides (erythromycin, clarithromycin), oxazolidinones (linezolid), can be effective because of the extensive amount of time the antibiotic binds to the microorganism. The inhibitory effect can be effective because their concentration exceeds the MIC for the microorganism.