MSD Finca Productiva Salud Del Hato

1. THE COVEXIN 10 STORY WHAT’S SO SPECIAL ABOUT COVEXIN 10?

4. How Does PZC Affect an Aluminum Adjuvant PZC pH +

5. How Does PZC Affect an Adjuvant pH 7.2 pH AlOOH PZC 9.5+ Alum PZC 4.5+ Point at Which Typical Vaccines are Blended + +

6. How Does PZC Affect an Adjuvant pH 7.2 pH AlOOH PZC 9.5+ Alum PZC 4.5+ Point at Which Typical Vaccines are Blended Protein of Interest PZC 5.5 0 + + +

7. How Does PZC Affect an Adjuvant pH 7.2 pH AlOOH PZC 9.5+ Alum PZC 4.5+ Point at Which Typical Vaccines are Blended Protein of Interest PZC 7.8 + + +

8. Aluminum Hydroxide Clostridial Toxoids Clostridial Toxoids Alum Blending Blending Al 3+ Al 3+ Al 3+ Al 3+ Al 3+ Al 3+ Al 3+ Al 3+ Al 3+ Al 3+

11. CLOSTRIDIAL VACCINE POTENCY Time Potency 3 yrs 6 mos Required potency

12. CLOSTRIDIAL VACCINE POTENCY

13. CLOSTRIDIAL VACCINE POTENCY Time Potency 3 yrs 6 mos Required potency

14. CLOSTRIDIAL VACCINE POTENCY Time Potency 3 yrs 6 mos New Potency Level

15. RESULTING RELEASE LEVELS ≥ 2.5 U/ml ≥ 4.6 U/ml C. septicum ≥ 1.0 U/ml ≥ 6.6 U/ml C. sordelli ≥ 2.5 U/ml ≥ 4.9 U/ml C. tetani ≥ 3.5 U/ml ≥ 6.0 U/ml C. novyi B ≥ 10.0 U/ml ≥ 11.7 U/ml C. haemolyticum Ph Eur pass Ph Eur pass C. chauvoei ≥ 5.0 IU/ml ≥ 5.3 IU/ml C. perfringens D ≥ 10.0 IU/ml ≥ 18.2 IU/ml C. perfringens B & C ≥ 0.5 U/ml ≥ 0.5 U/ml C. perfringens A Potency: EU Pharm Release Specification Covexin 10 Release specification Component

16. HOW DOES THIS HELP?

18. HOW THE TNT TEST WORKS Serum + Serum Toxin (10 Units) = All toxin neutralized ≥ 10 Antitoxin Units Mouse dead ≤ 10 Antitoxin Units

19. How Do We Stack Up Against the Leading Competitor?

20. How Do We Stack Up Against the Leading Competitor?

21. How Do We Stack Up Against the Leading Competitor?

22. How Do We Stack Up Against the Leading Competitor?

23. How Do We Stack Up Against the Leading Competitor?