1. Technical Presentation
Roundup Ready® Flex Cotton Update
Investor Tour
June 25, 2004
Leland, MS
Mark Oppenhuizen
Research Manager, Cotton
Roundup Ready® Flex cotton is not approved for sale or distribution in the United States.
1

2. Technical Presentation
Roundup Ready Flex Cotton
Presentation Outline
Product Concept
Discovery/Development
U.S. Field Testing (2000-2003)
Tolerance
Agronomic
Regulatory
Weed Management
2004 U.S. Field Testing
Seed Company variety development
Product Timelines
2

3. Technical Presentation
Roundup Ready® Flex Cotton
Product Concept
Over-the-top window of application
Roundup Ready® Flex Cotton
Roundup Ready®
Cotton
(< 4 lf.)
Emergence Layby Preharvest Harvest
Expanded window of application (over-the-top)
- Increased margin of crop safety
- More ‘flexible’ weed control
Increased grower convenience
Reduced need for specialized spray equipment
3

4. Technical Presentation
Roundup Ready® Flex Cotton
Discovery / Development
Roundup Ready Flex Cotton - MON 88913
Same gene as in Roundup Ready cotton – new promoters
Transformed Coker 312 cotton using the ‘Agro’ method
CP4 EPSPS protein is expressed in pollen, providing
reproductive tolerance to Roundup during flowering
Expression in rest of plant provides excellent vegetative tolerance
CP4 EPSPS Expression
Pollen viability
Roundup Ready Flex technology
Roundup Ready cotton Roundup Ready cotton Roundup Ready Flex technology
Mature Pollen
1.12 lb ae/A 4&8 node OT
4
- Chen, S., et al., July 2000.

5. Technical Presentation
Roundup Ready® Flex Cotton
U.S. Field Testing
2000-2003
Trial types
Tolerance
Agronomic
>60% of locations with
Regulatory University scientists
Weed Management
Systems / Demonstration
*does not include seed company partner breeding locations
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6. Technical Presentation
Roundup Ready Flex Cotton
Tolerance Field Trial
Leland, MS 2001
Roundup Ready Flex Roundup Ready Cotton
Cotton Events (Current Product)
Nontransgenic Buffer
Nontransgenic Buffer
Roundup applied OT @ 1.5 or 2.25 lb ae/A sequentially at 3,6,10 & 14 nodes
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7. Technical Presentation
Roundup Ready® Flex Cotton
Weed Management Systems Studies (2003)
Auburn University Oklahoma State University University of California
Clemson University Texas A&M University University of Georgia
Louisiana State University Texas Agricultural Experiment Station University of Missouri
Mississippi State University University of Arizona University of Tennessee
North Carolina State University University of Arkansas
Cotton Acres
5 – 13066
13066 – 37841
37841 – 76467
76467 – 169729
169729 – 306706 - Participating Universities
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8. 8
Technical Presentation
Entireleaf Morningglory
Ivyleaf Morningglory
Pitted Morningglory
Palmer Amaranth
+
+
lin
Red Sprangletop
lin
Yellow Nutsedge
ta
tha pre- y
a
e
ime ron p d bydb
i on
end
Pen metur lowe e
etu o ow o e
Goosegrass
om nt foll 8 nod
Velvetleaf
Sicklepod
-n
Fu
Flu rgent 5-8
2138a
t5
Cotton*
erg s te
Weed Control with Various Herbicide Treatments
e
g
em phosa
em o
p
g ly
g ly
+
+
b
al n
alin e-
a
r - by
eh
eth r
d im o p d b
dim on
Dr. Bob Hayes University of Tennessee Jackson, TN
d
Pen metur llowe de
Pe metu l o e de
l o en fo 3 4 no
f
o
2088a
n
Flu r ent e 3-4
erg ate
f
em phosa
e
ph
gy
g ly
fb
f fb
eaf
b
a
e + -2 le
s t r 1-
sat r
pho hlo node
hlo o
p
Gly etolac 3-4 n
Gl e o a -
2615a
e
S m os t
S-m osat
e
ph
p
g ly
g ly
b
b
af f
af
b
2 le
a
+
e+
st i - e
sat lin 1- de
Lbs Seed Cotton/A
po
pho hala o
o
Gly i t 3-4 n
Gly imet 3-4 n
2255a
end o ate
e
pen hosat
d
ph
gy
g ly
b
e fb
de
nod
a*
4n e
a
3-4 ode
e3
a e -8 no
sat 5-8 n
hs
pho te 5
lp ate
Gly hosa
2403a
pho ae ae
G y .5 lb
Gly .5 lb
c
1
@1
@
b
fb
ode
od
b
-4 n
a
3-4 de
e 3 n de
ae
sat 8 no
h s 58
pho a e 5-
l p sa t e
Gly
2802a
e
ae
pho b a
ph
g y 125 lb
gly .125 l
b
1
@1
ef
e af
-2 l
-
b
*1
a
**
te*
ate (fb) d .
osa (fb ode.
pho by
yph d by - no
Gly wed te 3-4
2741a
o t
o
f ll o a ae
fol hosa ae
a
ph b
g y .75 lb
gly .75 l
0
@0
@
WeatherMAX®
b
Phytotoxicity
(lbs ae or ai/A)
ai/A)
Treatments
**Roundup
100
90
80
70
60
50
40
30
20
10
0
2003
*Cotton
Percent Control (114 DAT-A)

9. Technical Presentation
Roundup Ready® Flex Cotton
Research Timelines/University Testing (2004)
University of Arkansas
Auburn University
~60
University of California
Clemson University
University of Florida
Louisiana State University University
University of Georgia
Mississippi State University Cooperator
University of Missouri
North Carolina State University Sites
University of Tennessee
Oklahoma State University
Research
USDA ARS
Texas A&M University
Weed Management
Virginia Tech
Texas Agric. Experiment Station
Crop Tolerance
University of Arizona ‘Systems research’
~30
~25
Roundup Ready®
Cotton launched
Glyphosate tolerant
cotton developed
Development of Additional Target
Roundup Ready Single internal
glyphosate tolerance field trials Launch*
Flex Cotton start field trial
in plants (EPSPS)
●
Early Early 1997 1998 1999 2000 2001 2002 2003 2004 2005 2006
1980s 1990s
* - pending regulatory approvals
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10. Technical Presentation
Roundup Ready® Flex Cotton
Field Testing
No. of field trial sites Field Research
250
• Efficacy testing
• Agronomic trials
200 • Regulatory studies
• University trials
• Seed company work
150
100
50
2001 2002 2003 2004
0
Year 10

11. Technical Presentation
Seed Companies
Monsanto expects to broadly license the
Roundup Ready Flex cotton trait.
Numerous seed companies are incorporating
Roundup Ready Flex cotton into their product
lines under existing R&D agreements.
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12. Technical Presentation
Roundup Ready®
Flex Cotton
Estimated Product Timelines
Event Testing & Selection 2000-02
Regulatory Trials 2002/03
Submissions to US, Japan* 2003/04
Approvals* 2005
Commercial Launch* 2006
*Targeted milestones and timelines. Commercialization will depend on many factors, including
successful completion of regulatory processes.
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