3. OVERVIEW
Mid-Season Check Point Indicates Continuing Momentum
in Pipeline Opportunities
ANNUAL R&D CYCLE: SEEDS & TRAITS JULY-AUGUST
MID-YEAR PIPELINE UPDATE
NEW ANALYSIS
Continued data analysis allows for additional
conclusions from 2005 U.S. field research
YieldGard Rootworm Dicamba-tolerant
soybeans
Nitrogen-utilization
Q1 Q4 corn
OFF-SEASON RESULTS
Southern Hemisphere field research has been
Q2 Q3 collected; Early indications support performance of
key projects
Drought-tolerant corn Insect-protected
soybeans
Higher-yielding
soybeans Omega-3 soybeans
EXPANDED OPPORTUNITIES
“HIT” designation becomes a new initiative to
enhance commercial impact of R&D
JANUARY
ANNUAL PIPELINE UPDATE Roundup RReady2Yield Soybeans
Project reviews, including phase
Coordinated biofuels strategy opens new
advancements and primary data
review from field research opportunities for Monsanto technology
3
4. NEW ANALYSIS
Second Year of Drought Pressure in Central Corn Belt
Demonstrating Performance Value of YieldGard Rootworm
KEY MARKET ACRES U.S. BRAZIL ARGENTINA
YieldGard Rootworm
AVAILABLE MARKET 25-30M 5M 1M
Corn
PERCENT PENETRATED 40% 0% 0%
U.S. DROUGHT MONITOR
PRODUCT INFO WEEK OF JULY 18, 2006
Indications are
there is drought
D0: Abnormally Dry
• YieldGard Rootworm
stress in areas of
D1: Drought - Moderate
delivers effective and
the Western Corn
consistent in-plant D1: Drought - Severe
Belt and Texas
protection against western, D1: Drought - Extreme
northern and Mexican corn
D1: Drought - Exceptional
rootworms
Source: U.S. Drought Monitor, Le Comte and Heddinghaus, CPC/NOAA: http://drought.unl.edu/dm
RETAIL
$17-$19/acre
VALUE/ACRE:
2006 Field pictures already
show a significant difference in
TOTAL ACRE the performance of YieldGard
25-30M (U.S.)
OPPORTUNITY:
Rootworm.
YIELDGARD SOIL-APPLIED
ROOTWORM INSECTICIDE
DISCOVERY PHASE III
PHASE I PHASE II PHASE IV LAUNCH
Adv. Development
Proof of Concept Early Development Pre-Launch
4
5. NEW ANALYSIS
Early Field Testing Indicates Nitrogen Utilization Corn
Offers Yield Benefits in Limited Nitrogen Conditions
KEY MARKET ACRES U.S. BRAZIL ARGENTINA
Nitrogen utilization AVAILABLE MARKET 80M 30M 6M
corn PERCENT PENETRATED 0% 0% 0%
NITROGEN UTILIZATION CORN PERFORMANCE IN
PRODUCT CONCEPT NEW 2005 UNDER LIMITED NITROGEN ENVIRONMENTS
• Nitrogen-utilization corn
40
targets ways that corn
PRODUCT
plants can use nitrogen
A V E R A G E Y IE L D 30
IN C R E A S E (% )
CONCEPT
more efficiently, exploring
YIELD
RESULTS UPDATE
the potential to boost yield BENEFIT
20
under normal nitrogen TARGET
RANGE
conditions or stabilize yield
in low nitrogen
10
environments
0
Medium
GENE CONSTRUCTS
RETAIL
(>$10/acre to
VALUE/ACRE:
<$30/acre)
In expanded testing with more than 30 genes, nitrogen
utilization corn showed a yield advantage of approximately 10
High percent in limited nitrogen environments
TOTAL ACRE
OPPORTUNITY:
(>20M acres)
Previous data indicated nitrogen utilization corn offered yield
benefits at normal levels of nitrogen as well
DISCOVERY PHASE III
PHASE I PHASE II PHASE IV LAUNCH
Early Development Adv. Development
Proof of Concept Pre-Launch
5
6. NEW ANALYSIS
Dicamba-Tolerant Soybeans Have Two Modes of Action and
Represent Third-Generation Herbicide Tolerance
KEY MARKET ACRES U.S. BRAZIL ARGENTINA
Dicamba-tolerant AVAILABLE MARKET 70M 60M 35M
soybeans PERCENT PENETRATED 0% 0% 0%
DICAMBA-TOLERANT SOYBEANS PERFORMANCE
PRODUCT CONCEPT NEW
AT INCREASING APPLICATION RATES
• Dicamba-tolerant soybeans
70
provide a new, unique
A V E R A G E Y IE L D (L B /A C )
60
mode of action, designed
50
to provide soybean
RESULTS UPDATE
40
growers with the most
30
effective weed
20
management system
available and to be used in 10
conjunction with 0
Monsanto’s Roundup EVENT 1 EVENT 2 EVENT 3 EVENT 4 EVENT 5
RReady2Yield trait
UNSPRAYED PRE-EMERGENT
Medium
RETAIL
(>$10/acre to
VALUE/ACRE: POST-EMERGENT PRE-EMERGENT/POST-EMERGENT
<$30/acre)
2005 multi-location field tests demonstrate Dicamba-tolerant
High
TOTAL ACRE
OPPORTUNITY: soybeans are conferring effective tolerance to the plants with
(>20M acres)
no yield penalty with pre-emergent and post-emergent
applications
DISCOVERY PHASE III
PHASE I PHASE II PHASE IV LAUNCH
Early Development Adv. Development
Proof of Concept Pre-Launch
6
7. OFF-SEASON RESULTS
Off-Season Field Data Reinforces Potential for Yield
Benefit of Drought-Tolerant Corn
KEY MARKET ACRES U.S. BRAZIL ARGENTINA
AVAILABLE MARKET 80M 30M 6M
Drought-tolerant corn PERCENT PENETRATED 0% 0% 0%
P R O JE CT
UNDER DROUGHT STRESS, HYBRIDS WITH BEST-
PRODUCT CONCEPT NEW PERFORMING EVENTS SHOW YIELD ADVANTAGE OVER
CONTROLS
16%
• Drought-tolerance is a
AVERAGE YIELD BENEFIT (%)
family of products, aimed
14%
AFTER DROUGHT STRESS
at providing consistent
12%
RESULTS UPDATE
yield and buffering against
10%
the effects of water PRODUCT
CONCEPT
8%
limitations
YIELD
6% BENEFIT
TARGET
4%
Variable,
RANGE
RETAIL
2%
based on
VALUE/ACRE:
market
0%
U.S. 2004 (4 U.S. 2005 (5 S. AMERICA
LOCATIONS) LOCATIONS) 2005-2006 (5
High
TOTAL ACRE
OPPORTUNITY:
LOCATIONS)
(>20M acres)
Under stressed conditions in South America, drought-tolerant
trait showed a yield benefit at product-concept targets –
reinforcing the results seen for two years in the U.S.
DISCOVERY PHASE I PHASE III
PHASE II PHASE IV LAUNCH
Proof of Concept Early Development Adv. Development Pre-Launch
7
8. OFF-SEASON RESULTS
Higher-Yielding Soybeans Showed Improved Yield in
2006 Testing
KEY MARKET ACRES U.S. BRAZIL ARGENTINA
Higher-yielding AVAILABLE MARKET 70M 60M 35M
soybeans PERCENT PENETRATED 0% 0% 0%
HIGHER-YIELDING SOYBEAN PERFORMANCE
PRODUCT CONCEPT NEW
VERSUS CONVENTIONAL CONTROLS
12%
AVERAGE YIELD ADVANTAGE
• Higher-yielding soybeans
10%
are aimed at boosting the
(% OF CONTROL)
intrinsic yield potential of
RESULTS UPDATE
8%
the soybean through
insertion of key genes PRODUCT
6% CONCEPT
YIELD
4% BENEFIT
Medium
TARGET
RETAIL
2% RANGE
(>$10/acre to
VALUE/ACRE:
<$30/acre)
0%
EVENT 1 EVENT 2 EVENT 3
High
TOTAL ACRE
OPPORTUNITY: 2005: U.S., 19 LOCAT IONS 2006: ARGENT INA, 15 LOCAT IONS
(>20M acres)
Three seasons of testing in 43 environments has demonstrated
consistent yield enhancement, with increased yield
improvement from 2005 to 2006
DISCOVERY PHASE I PHASE III
PHASE II PHASE IV LAUNCH
Proof of Concept Early Development Adv. Development Pre-Launch
8
9. OFF-SEASON RESULTS
Insect-Protected Soybeans Create New Opportunity in
South America
KEY MARKET ACRES BRAZIL ARGENTINA
Insect-protected AVAILABLE MARKET 60M 35M
soybeans PERCENT PENETRATED 0% 0%
INITIAL PERFORMANCE OF INSECT-PROTECTED
PRODUCT CONCEPT NEW
SOYBEANS
• Insect-protected soybeans
6%
use the Bt technology
OVER NO-INSECTICIDE
5%
widely adopted in corn and
AVERAGE YIELD
INCREASE (%)
cotton to control insect 4%
CONTROL
RESULTS UPDATE
pests in soybeans, which
3%
are especially
economically important for 2%
South American farmers
1%
0%
Small
RETAIL
VALUE/ACRE: INSECTICIDE-TREATED INSECT-PROTECTED
(<$10/acre)
SOYBEANS
Initial field trials of Insect-protected soybeans in Argentina
Medium demonstrated significant yield protection versus insecticides
TOTAL ACRE
(>5M acres to in mild-to-moderate insect infestations
OPPORTUNITY:
<20M acres)
Intended as a stacked offering with the Roundup Ready family
for herbicide control
DISCOVERY PHASE III
PHASE I PHASE II PHASE IV LAUNCH
Early Development Adv. Development
Proof of Concept Pre-Launch
9
10. OFF-SEASON RESULTS
Omega-3 Soybeans Have Met Early Development
Targets for Both Food Application and Field Performance
KEY MARKET ACRES U.S.
AVAILABLE MARKET <5M
Omega-3 soybeans PERCENT PENETRATED 0%
CONSISTENT AGRONOMIC PERFORMANCE OF
PRODUCT CONCEPT NEW
OMEGA-3 SOYBEANS IN FIELD TRIALS
80
• Omega-3 soybeans
70
represent a land based
AVERAGE YIELD
supply of essential Omega- 60
3 fatty acids. With soybean
RESULTS UPDATE
50
(BU/AC)
oil that would contain 20% OMEGA-3
40
stearidonic acid (SDA), the CONTROL
intent is for taste, shelf-life 30
and oil stability to be as 20
close to soybean oil as
10
possible with a superior
0
profile when compared
U.S. 2004 (10 ARGENTINA U.S. 2005 (15 ARGENTINA
with fish oil
LOCATIONS) 2004-2005 (12 LOCATIONS) 2005-2006 (12
LOCATIONS) LOCATIONS)
High
RETAIL
New data focuses on field performance, demonstrating Omega-3
VALUE/ACRE:
(>$30/acre) soybean yield is on par with commodity soybeans – an important
factor to farmers growing specialty crops
Small
TOTAL ACRE
OPPORTUNITY:
Previous data focused on oil properties such as initial smell, taste
(<5M acres)
and shelf-life characteristics
DISCOVERY PHASE III
PHASE I PHASE II PHASE IV LAUNCH
Early Development Adv. Development
Proof of Concept Pre-Launch
10
11. EXPANDED OPPORTUNITITES
“HIT” Projects Streamline Internal Work and Bolster
Commercial Readiness
High-Impact Technology: A designated sub-set of the R&D pipeline placed on a
graduated track to streamline development work and improve commercial readiness,
reflecting enhanced confidence and certainty in our ability to launch a commercially
P R O JE CT
meaningful product; Designed to pull forward the Net Present Value (NPV) through
larger-acre launches in elite germplasm with a greater financial benefit.
Roundup RReady2Yield soybeans
P R O JE CT
PHASE III
• Parallel work in breeding and
biotechnology
• Simultaneous regulatory work,
submissions moving forward along
with project testing for key launch
countries
Drought-tolerant corn
P R O JE CT
PHASE II
• Parallel work in breeding and
biotechnology
• Early-stage R&D and commercial
integration
Vistive III soybeans
P R O JE CT
PHASE II
• Progress will allow Vistive III to “leap-
frog,” shortening the gap in
commercialization between Vistive I and
Vistive III
11
12. EXPANDED OPPORTUNITIES
Roundup RReady2Yield Soybeans Offer Yield Improvement
Over First-Generation Roundup Ready Soybeans
KEY MARKET ACRES U.S. BRAZIL ARGENTINA
Roundup RReady2Yield AVAILABLE MARKET 70M 60M 35M
Soybeans PERCENT PENETRATED 0% 0% 0%
P R O JE CT
PRODUCT CONCEPT 1996 FORWARD
PRONOUNCED
USDA NASS U.S. SOYBEAN YIELD
• Roundup RReady2Yield is 50
SHIFT UPWARD
(MULTIPLE REGRESSION MODEL ANALYSIS)
the second-generation of IN BU/AC YIELD
Monsanto’s popular
40 With the introduction
AVERAGE YIELD (BU/AC)
herbicide-tolerant platform of Roundup Ready
RESULTS UPDATE
in soybeans that will soybeans in 1996, a 1
30 percent increase in
provide farmers with
Roundup Ready
soybeans that have
soybean acreage is
enhanced yield, with a 20 associated with a 10
target of up to 5 bushel- percent increase in
per-acre yield improvement the normal per-year
10 yield gain. Roundup
over comparable Roundup
Ready2Yield soybeans
Ready soybeans
are expected to
Medium continue this growth
1920 1930 1940 1950 1960 1970 1980 1990 2000 2010
RETAIL in yields.
(>$10/acre to
VALUE/ACRE:
<$30/acre)
ACTUAL YIELD PREDICTED YIELD
OUTLIER EXCLUDED
High
TOTAL ACRE
UPPER & LOWER 99% CONFIDENCE INTERVAL
OPPORTUNITY:
(>20M acres)
Source: USDA National Agricultural Statistics Service (NASS): http://www.nass.usda.gov:8080/QuickStats/
DISCOVERY PHASE III
PHASE I PHASE II PHASE IV LAUNCH
Early Development Adv. Development
Proof of Concept Pre-Launch
12
13. NEW OPPORTUNITIES
Opportunity in Renewable Fuels is Driving Demand in
Agriculture
U.S. & BRAZIL ETHANOL OUTLOOK
ETHANOL MARKET 20 30
BILLIONS OF GALLONS
27
U.S. and Brazil represent greater than 95% of
MILLIONS OF ACRES
global ethanol market 24
15
21
By 2015, ethanol should grow from 8B to 20B
gallons 18
Assumptions: 10 15
12
In U.S., 10% of gasoline demand from ethanol by
2015 9
5
In Brazil, 20% - 24% of gasoline from ethanol 6
Corn for ethanol grows from 11M to 27M acres 3
0 0
Sugarcane for ethanol grows from 6.5M to 12.5M
2005 2006 2007 2008 2009 2010 2011 2012 2013 2014 2015
acres
CORN
U.S.
BIODIESEL MARKET SUGARCANE
BRAZIL
U.S. and EU represent 95% of global biodiesel
GLOBAL BIODIESEL OUTLOOK
4 20
market
BILLIONS OF GALLONS
18
MILLIONS OF ACRES
3.5
By 2012, biodiesel should more than triple from
16
1B to 3.4B gallons 3
14
Assumptions: 2.5 12
In EU, biodiesel approaches 5.75% of total 2 10
transport fuel by 2010 8
1.5
6
In U.S., tax credit extends to 2012
1
4
Rapeseed and canola for biodiesel grow from 6M 0.5 2
to 10M acres
0 0
Soy for biodiesel grows from 2M to 20M acres
2005 2006 2007 2008 2009 2010 2011 2012
Palm for biodiesel grows from 0.3M to 1.5M acres PALM
BIODIESEL
SOYBEAN
RAPESEED & CANOLA
Source: Proexporter Network, Pro Mar And Monsanto Estimates
13
14. NEW OPPORTUNITIES
While Pathways to Participate in Biofuels Marketplace Vary,
Monsanto Is Focusing on Three Primary Raw Materials
SOURCES FOR MAJOR BIOFUEL CATEGORIES
MARKET SOURCES
FOCUS
ETHANOL
ETHANOL
Sugarcane
Corn Increased Yield
Cellulosic
High Fermentable
Switchgrass
Corn
Trees (Poplar, Pine)
89 91 Renessen Corn
DIESEL Miscanthus
Processing System
Waste (Pulp, Hulls)
E85 Alfalfa Expanded Acres
ETHANOL BIODIESEL
BIODIESEL
Palm
BIODIESEL Increased Yield
Soybean
Higher Oil
Rapeseed / Canola
Expanded Acres
Corn
Jatrapha
14
15. ETHANOL
Processor Preferred High Fermentable Corn Hybrids
Proven to Enhance Ethanol Yields
MONSANTO PROCESSOR PREFERRED
HIGH FERMENTABLE CORN (HFC)
USE OF
ETHANOL YIELD IMPROVEMENT PROCESSOR
ETHANOL UPDATE
THROUGH HIGH FERMENTABLE CORN PREFERRED CORN
CAN SHIFT THE
Average yield for a
ETHANOL YIELD
conventional dry mill is
DISTRIBUTION
2.8 gallons of ethanol
for every 1 bushel of
CURVE TO THE
corn
RIGHT 140
900
OPPORTUNITY
PROCESSOR PREFERRED HYBRIDS
800
An ethanol plant that 120
actively sources HFC
NUMBER OF SAMPLES
700
PROCESSOR PREFERRED
NUMBER OF SAMPLES
can improve ethanol
100
#2 YELLOW CORN
yields #2 YELLOW CORN
600
HFC provided an 2.7%
80
500
average increase in
ethanol yields in large
400 60
scale commercial trials
across 7 states and
300
Canada in 2003 – 2004 40
200
Some ethanol plants
are paying a premium 20
100
of $0.05-$0.08 per
bushel for Processor
0 0
Preferred HFC hybrids
45.00
46.00
47.20
48.20
49.20
50.20
51.20
52.20
53.20
54.20
55.20
PREDICTED ETHANOL YIELD (NIT UNITS)
15
16. ETHANOL
Breeding and Biotechnology in Corn Provides Greater Yield
and Consistency Necessary to Fuel Ethanol Markets
FOCUS: IOWA ETHANOL REFINERIES
ETHANOL DRAW AREA
290K corn acres required
to supply a 100M gallon
dry mill
OPPORTUNITY
Ethanol draw acres are
DUBUQUE
likely to be highly
technified with elite
SIOUX
Processor Preferred
CITY CEDAR
germplasm combined in a
RAPIDS
future 4-way stack
IOWA
Monsanto’s molecular
CITY
AMES
breeding will double the
DAVENPORT
rate of genetic gain
versus conventional
DES
breeding
MOINES
ONE OF MONSANTO’S
FUTURE 4-WAY STACKS BURLINGTON
YIELDGARD
CORN BORER
YIELDGARD
ROOTWORM
ROUNDUP
READY CORN 2
MAVERA™
DRAW AREA FOR
HIGH VALUE ETHANOL PLANTS UNDER
ETHANOL PLANTS IN WET MILL
ETHANOL DRY MILL
CORN WITH CONSTRUCTION
PRODUCTION
LYSINE
16
Source: Renewable Fuels Association and Monsanto estimates
17. ETHANOL
Renessen Corn Processing System Has Potential to
Change Competitive Landscape in Ethanol Production
ETHANOL FACILITY VALUE STREAM COMPARISON
ETHANOL UPDATE
ETHANOL PRODUCTION FACILITY
VALUE STREAMS
Capacity of 4.7B
1
gallons should
increase to 13B
gallons after turn of
ETHANOL
decade
CONVENTIONAL DRY MILL
Competition likely to
PROCESS
become more intense
DDG
as incentives
decrease and more
ethanol facilities come
on line
OPPORTUNITY
ETHANOL
2
(increased yield and
Renessen corn
throughput)
processing system is
poised to
ENHANCED DDG
RENESSEN CORN
demonstrate
(increased protein content
PROCESSING SYSTEM
competitive
and reduced utility costs
COUPLED WITH
advantage over
because of lower volumes
conventional facilities
CONVENTIONAL DRY MILL
of DDG)
by producing higher
PROCESS
value co-products and
NUTRIENT RICH MEAL
higher fermentable
FOR SWINE & POULTRY
starch for ethanol
HIGH VALUE CORN OIL
FOR FOOD AND BIODIESEL
NOTE: DDG = DISTILLERS DRIED GRAIN
17
18. BIODIESEL
Soybean and Canola Pipeline to Deliver Greater Value to
Farmers and Processors for a Growing U.S. Biodiesel Market
FOCUS: U.S. BIODIESEL PLANTS
U.S. BIODIESEL INDUSTRY
In 2006, capacity is 400M
gallons with 65 plants in
production
50 plants under
construction and 8
expansion projects should
add 700M gallons in 2007
OPPORTUNITY
Soybean oil is the
predominant feedstock for
U.S. biodiesel plants
Canola from Canada may
represent a growing
segment of supply
Roundup Ready soybeans
are on 95% of soybean
acres providing increased
reliability to oilseed
crushers
Pipeline traits should
provide greater value and
reliability
BIODIESEL
BIODIESEL PLANTS UNDER
BIODIESEL PLANTS IN PLANT
CONSTRUCTION
PRODUCTION EXPANSION
18
Source: National Biodiesel Board And Monsanto estimates
19. BIODIESEL
High Oil Soybeans To Deliver Value Regardless of End
Use in Feed or Fuel
High oil soybeans
PRODUCT CONCEPT
HIGH OIL SOYBEANS IN U.S. FIELD TRIALS
24
• High oil soybeans to
increase total product
offering by improving
RESULTS UPDATE
refinery yield and meal
22
protein
% Oil
20
Low
RETAIL
VALUE/ACRE:
(<$10/acre)
18
Neg. Pos. Neg. Pos.
Small
TOTAL ACRE
OPPORTUNITY:
(<20M acres) Event 1 Event 2
OIL QUANTITY ADVANTAGE OVER CONVENTIONAL CONTROLS
ACROSS MULTIPLE EVENTS
DISCOVERY PHASE III
PHASE I PHASE II PHASE IV LAUNCH
Early Development Adv. Development
Proof of Concept Pre-Launch
19
20. SUMMARY
Pipeline to Deliver Additive Value to Biofuels Marketplace
ROUNDUP RREADY2YIELD SOYBEANS
Target of up to 5 bu/acre yield increase over comparable
Roundup Ready soybeans
Target of up to 6 gal/per acre of biodiesel increase
INSECT-PROTECTED SOYBEANS
Demonstrated yield gains over insecticide treated checks
Increased yield per acre translates to increased oil per
acre
DROUGHT-TOLERANT CORN
Yield advantage of best performing events under drought
stress in Argentina
10% target yield increase corresponds to 10% more
gal/acre of ethanol
NITROGEN-UTILIZATION CORN
Targeting ways plants can use nitrogen more efficiently
A 10% target yield increase in limited nitrogen
environments corresponds to 10% more gal/acre of
ethanol
HIGHER-YIELDING SOYBEANS
3rd year of testing demonstrates consistent yield benefits
Up to an additional 6 gal/acre of biodiesel
HIGH-OIL SOYBEANS FOR PROCESSING
Offers dual role benefiting oil and feed processors
20
21. SUMMARY
R&D Pipeline Holds More Potential Backed By Performance
Than Any Time In Monsanto’s Recent History
APHIS PERMIT APPLICATIONS
FOR BIOTECH FIELD TESTING – 1ST QUARTER 2006
196
200
180
160
140
109
120
100 83
80
80
60
40 21
7
20 3
2 2
0 0 0
0
MONSANTO BASF DOW PIONEER SYNGENTA TOTAL
CORN SOYBEAN
Source: Seed Today, Second Quarter 2006, Vol.10 No.2
21