The document describes a proposed collaborative knowledge translation wiki called COLT that would allow primary care practitioners to participate in synthesizing evidence and engaging in ongoing discussions to facilitate faster dissemination of knowledge. It would be modeled after an existing textbook but updated continuously online. Researchers envision COLT being developed through partnerships and involving practitioners in content creation and review to share best practices and resources on an open collaboration platform. Evaluation research is planned to understand impacts on behaviors and clinical decision-making.