1. organizmisa da ujredis dabereba. SeiZleba Tu ara viyoT ukvdavni? konstantine WiWinaZe (sakontaqto el. fosta [email_address] ) i. beritaSvilis sax. fiziologiis instituti; i. javaxiSvilis sax. Tbilisis saxelmwifo universiteti

2. Older, But Wiser

4. asakTan erTad organizmSi metabolizmis intensivobis daqveiTebis grafiki

5. mamakacis sasqeso hormonis – testosteronis koncentraciis Semcireba sisxlSi asakTan erTad

6. Zvlis sisqe 25 da 75 wlis adamianebSi

7. smenis daqveiTebis maCveneblebi 75 wlis adamianSi (25 wlianTan SedarebiT)

9. daberebis procesis mizezebze ori tradiciuli midgoma arsebobs: 1. dabereba winaswar daprogramebuli procesia (TeoriaTa umravlesobaSi – genetikurad daprogramebuli). informacia daberebis Sesaxeb Cawerilia sxvadasxva matareblebze (ZiriTadad dnm-Si). garemo faqtorebs SedarebiT umniSvnelo roli aqvT am procesSi. 2. dabereba – organizmze moqmedi sxvadasxva destruqciuli Zalebis zemoqmedebis Sedegia. organizmi erTgvarad “cvdeba”.

10. dabereba organizmis ujredis paTologiuri normaluri replikaciuri (dakavSirebuli gayofasTan) droiTi (dakavSirebuli drois xangrZlivobasTan)

11. mravalujrediani organizmis dabereba praqtikulad gauyofadi ujredebis (nervuli da kunTovani) “ Sromisunarianobis” daqveiTeba gayofadi ujredebis prolifireciis (gayofis) unaris daqveiTeba

12. sicocxlis maqsimaluri xangrZlivoba sxvadasxva saxeobebSi

13. sicocxlis saSualo xangrZlivoba sxvadasxva epoqaSi 19,0 21,5 20–30 27,5 29,0 28,5 35,6 40,6 44,8 56,0 59,8 57,7 73 qvis xana brinjaos xana antikuri xana XVI s . XVII s . XVIII s . 1801–1880 ww . 1891–1900 ww . 1901–1910 ww . 1924–1926 ww . 1932–1936 ww . 1946–1947 ww . 1970–1980 ww . asaki (w.) saukuneebi, wlebi

14. sicocxlis saSualo xangrZlivobis dinamika ruseTsa da did britaneTSi (1965-2000 ww.) 14 w 3 w Britain Russia

17. mozrdilTa progeria (verneris sindromi)

18. bavSvTa progeria (hatCinson-hilfordis sindromi)

19. hatCinson-hilfordis sindromiT daavadebuli bavSvebi iRupebian saSualod 12-13 wlis asakSi adamianis normaluri siberisTvis damaxasiaTebeli daavadebebisgan. Tumca maTi gonebrivi ganviTareba Seesabameba maT qronologiur asaks

20. hatCinson-hilfordis sindromiT daavadebuli bavSvi 3 Tvis, 13 Tvis, 3 wlisa da 11 Tvis, 6 wlisa da 6 Tvis, 9 wlis asakSi

21. daberebuli fibroblastebi axalgazrda fibroblastebi

23. qromosomul boloebs specializirebuli struqturebi – telomerebi warmoadgenen Blue = chromosomes White = Telomere protein

24. dnm-is replikaciis sqema – Svileuli molekulebis warmoqmna

25. replikaciuri makrateli

26. replikaciur makratelSi dnm-is kopiebis warmoqmnis sqema

27. qromosomis arareplicirebuli 5 ’ bolos warmoqmnis amsaxveli sqema

28. telomeruli bolos damatebis sqema

29. telomerebi, ujredis gayofa da replikaciuri sibere

30. telomerebi da simsivne

31. daberebis Tavisufal-radikaluri Teoria

34. Tavisufali radikalebiT inicirebuli procesebi ОН ’ radikali proteinebi - kargaven Tavis funqciebs lipidebi – ziandebian yvelaze metad. warmoiqmneba “ lipiduri xaze” nukleinmJavebi – mTlianad an nawilobriv kargaven Tavis funqciebs

35. Jangbadis reaqtiuli formebiT (ROS) da Tavisufali radikalebiT inicirebuli procesebi

36. intaqturi (marcxniv) da Tavisufali radikalebis zemoqmedebis myofi ujredi (marjvniv)

40. Tavisufali radikalebis generaciis mitoqondriuli gzebi

41. oqsidaturi stresi da dabereba: aqvT mitoqondriebs kritikuli roli?

42. Tavisufali radikalebis Semakavebeli antioqsidanturi sistemebi

43. Caenorhabditis elegans sicocxlis xangrZlivobis grafiki. Savi – normaluri egzemplarebi lurji da wiTeli – gamorTuli sxvadasxva mitoqondrialuri sod-ebiT ( Van Raamsdonk J.M., Hekimi S. Deletion of the Mitochondrial Superoxide Dismutase sod-2 Extends Lifespan in Caenorhabditis elegans // PLoS Genetics. 2009 . 5 ( 2 ): e1000361 )

45. Pathways that Impact Mammalian Aging

46. ujredis daberebis centrosomuli (centrioluri) Teoria

48. centrosomis agebulebis gamartivebuli sqema ( ZuZumwovarTa interfazul ujredi)

49. eukariotebis citoConCxi. aqtinuri filamentebi SeRebilia wiTlad, tubulinuri filamentebi – mwvaned, birTvi - cisfrad

50. eukariotebis citoConCxi. keratinuli gardamavali filamentebi.

55. gmadlobT yuradRebisaTvis!