This document discusses strategic doing, a new discipline for developing and implementing strategy in loose regional networks. It provides examples of how strategic doing has helped various regions and communities adjust to globalization, develop digital corridors and workforce innovations, and improve small business vitality. The lessons learned are that innovating networks take time to evolve through open innovation in stages, and depend on tight cores, porous boundaries, boundary spanners, collective strategy, moving words into action to build trust, and civility.