1. Lombardi Comprehensive
Cancer Center
Cancer Informatics Summit
2/21/2013
Subha Madhavan, Ph.D.
Director, Innovation Center for Biomedical Informatics
Georgetown University Medical Center
Director, Clinical Research Informatics
Lombardi Comprehensive Cancer Center

2. Vincent T. Lombardi
• Famous professional
football coach
• Fell ill at Washington
Redskins’ practice on
Georgetown
University field
• Treated for cancer at
Georgetown
“Winning isn’t everything, it’s
the only thing.”
• Cancer Center
named in his honor

3. Lombardi – At a glance
• Established in 1970
• In 1974, Georgetown Lombardi became the 16th
NCI-designated Comprehensive Cancer Center
• Over $100M in research funding ever year
– $35M CCSG + peer-reviewed funding base
• 94 full members; 186 cancer-connected faculty
members
• 4 Research programs & 9 Shared resources
• 220 ongoing trials

4. Key Accomplishments
• Development of human papillomavirus (HPV)
vaccine to prevent cervical cancer
– R. Schlegel
• Discovery of GADD-4 DNA repair gene
– A. Fornace
• Nuclear hormone receptor networks in breast
cancer
– R. Clarke
• Monoclonal antibody therapy
– L. Weiner

5. General Organizational Structure
Director
(Weiner)
Deputy Director
(Atkins)
Clinical Care
(Marshall)
Clinical
Research
(Giaccone)
Population
Sciences
(Mandelblatt)
Basic Research
(Wellstein)
Minority Health
(Campbell)
Shared
Resources
(Byers)
Administration
(VanderHoek)

6. Another view of the cancer center
IAC
EAC
Director
Deputy Dir
Community
Advisory Council
AD
Basic/Transl
Network
Representative
Administration
Research Education
MO
CPC
BC
ET
Trial Oversight
AD Clinical
Shared Resources
AD
Administration
AD Minority
Health
AD
Population
AD Shared
Resources

7. Informatics @ Georgetown

8. Innovation Center for Biomedical Informatics (ICBI)
http://icbi.georgetown.edu/
•
•
•
•
•
•
Faculty – 5
Senior staff members – 5
Research associates – 5
Support staff – 2
Consultants – 5
Students/Trainees - 2
Expertise in bioinformatics, clinical informatics, biomathematics,
biostatistics, clinical genomics, molecular biology, high-throughput
molecular assays, enterprise class software development, data
management, data security, & project management

9. Informatics Org Chart
Cancer
Center
Director
CCSG SR
Director
CTSA PI
Dean of
Research
ICBI Director
Director, Operations
Office Manager
Highthroughput
omics
Financial Analyst
Communications/
Scientific writing
Technology
Development
Health IT
ChemiInformatics
Data Coordination
& Biocuration
FTEs supporting Cancer Center – 8
Total FTEs - 22
Clinical
Research
Informatics

10. Informatics Funding
$3.5M Total Annual Funding in 2012

11. Lombardi Information Architecture
(current & future)

12. Integrated Data Environment:
G-DOC Links to Many of Data Silos
Pathway Studio
Cytoscape
• Systems biology
• Literature
•Visualization
networks
JMol/Marvin
Ingenuity Analysis
• Molecule
Visualization
•Pathways, GO,
Variants
G-DOC
RedCap
Clinical
Research
JBrowse
•Genome
Visualization
Disease
Classification
Tools
EHR’s

13. https://gdoc.georgetown.edu
Over 330 registered
users from six countries
~250 unique hits/month

14. Making Patients Part of Healthcare Through
Technology Innovations

15. Next Generation Sequencing
Big Data Analytics on the Cloud
Genomic Data
De-identified Clinical data
PC
User
Genome Data
Amazon S3
Bucket
Amazon EC2
Compute
Instances
G-DOC Web
Portal
Clinical Data
Amazon
Glacier Vault
MongoDB EC2
Instances
Oracle RDS
Instance

16. Informatics for
Discovery, Clinical Research, Clinical Care
• ‘omics’ data analysis
Clinical Research
Clinical Education
• EHR/PHR integration
• Informatics
education
• Biomarker discovery
• Partnerships
• Disease
classification
• Joint grants
• Genotype-Phenotype
correlation
• Contracted services
• Biospecimen
management and
analysis
• Medical internships
• Joint appointments
• Shared resources
• Shared IP
• Technology/method
development
• Joint publications
Basic/Traslational
Biospecimen
Website : https://icbi.georgetown.edu
Email : icbi@georgetown.edu

17. Challenges & Opportunities
Major Challenges:
 Diverse set of policies and regulations across
participating institutions
 Lack of resources (human and IT)
 Multiple clinical & research information silo’es
Significant Opportunities/Strengths:





Technology development
Community engagement
Test bed for innovation
‘omics’ methods & integration
Collaborations with CTSA