Human genome project 2007

Human Genome Project Potential Applications

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Genomics ,[object Object],[object Object]

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polycystic ovary syndrome ,[object Object]

polycystic ovary syndrome ,[object Object],[object Object]

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Gynecological oncology ,[object Object]

cystic fibrosis ,[object Object],[object Object],[object Object]

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Gene therapy It means modification of the genetic material of living cells This applies to genetically determined diseases but may also expanded to diseases that occur later in life

Highly promising ,[object Object],[object Object],[object Object]

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Somatic cell gene therapy The Concept Natural ability of viruses to enter cells through receptors genetically altered to carry normal human DNA.

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Familial Hypercholesterolemia ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

It is the future ,[object Object],[object Object]

Role in oncology ,[object Object],[object Object]

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Gene Therapy: Simple in Theory but Difficult in Practice

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Nonviral approach (2003) ,[object Object],[object Object]

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Stem Cells Alzheimer’s Disease Parkinson’s Disease Various Leukemias Hodgkin’s Lymphoma Non-Hodgkin’s Lymphomas Heart Disease Diabetes Multiple Sclerosis Huntington’s Disease Osteoarthritis Coeliac Disease Crohn’s Disease Lupus Erythematosus Sickle Cell Anaemia Thalassemia Blackfan Diamond Anaemia Fanconi Anaemia

Types of Stem Cells Pluripotent Stem Cells: Can give rise to all different cell types in vitro . Multipotent Stem Cells: Can give rise to several cell types of a tissue or organ. Unipotent Stem Cells: consist of a single cell type only.

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Isolation of Embryonic Stem Cells Embryonic Stem cells Culture Inner Cell Mass BLASTOCYST 5-7 day old embryo

Differentiation of E.S.C. Using particular treatment regimes, embryonic stem cells can be made to differentiate into many types of cell. This is because they are pluripotent . Embryonic Stem Cells Liver Cells Muscle cells Skin cells

Human genome project 2007

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Human genome project 2007