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Radioterapi and Chemotherapy plan

    A. Darah
    1. Blood count :
           a. Leucosite
           b. Haemoglobin
           c. Thrombosite
    2. Fungsi hati
    3. Fungsi ginjal – creatinin clearence ( tampung urine 24 jam )
    4. Kadar Gula Darah Puasa dan 2 jam pp



    B. Foto
    1. X ray foto Thorax
    2. CT Scan Nasofaring



    C. Biopsi
    1. Insisi biopsi tumor
    2. Aspirasi biopsi kelenjar getah bening



Therapy




Follow-up
Follow-up for patients includes the following:

    1.   Routine periodic examination of the original tumor site and neck.
    2.   CT or PET-CT scan.
    3.   MRI scan.
    4.   Blood work.
    5.   EBV titers.
    6.   Monitoring of patients should include the following:

         Surveillance of thyroid and pituitary function.

         Dental and oral hygiene.

         Jaw exercises to avoid trismus.

    7. Evaluation of cranial nerve function, especially as it relates to vision and hearing.
8. Evaluation of systemic complaints to identify distant metastasis.



Although most recurrences occur within 5 years of diagnosis, relapse can be seen at longer intervals.
The incidence of second primary malignancies is less than after treatment of tumors at other head
and neck sites.[11]



Poorly differentiated squamous cell cancer has been associated with EBV antibodies.[4,12] High-titer
antibodies to virus capsid antigen and early antigen, especially of high IgA class, or high titers that
persist after therapy, have been associated with a poorer prognosis.[13] This finding remains under
evaluation.



Tumors of many histologies can occur in the nasopharynx, but this discussion, like the American Joint
Committee on Cancer nasopharynx staging, refers exclusively to WHO grade I-, II-, and III-type
nasopharyngeal carcinoma.

Routine staging procedures include:

history, physical examination including cranial nerve examination, complete blood cell count, serum
biochemistry (including liver function test), chest X-ray, nasopharyngoscopy, computed tomography
(CT) scan or magnetic resonance imaging (MRI) of nasopharynx and base of skull and neck. MRI is
preferred if available [III, B].

Imaging for distant metastases including isotope bone scan and CT scan of chest and upper
abdomen could be considered for at-risk subsets (node positive, especially N3 stage) and for those
patients with clinical or biochemical abnormalities detected [III, B]. The use of positron emission
tomography is under investigation and findings seem promising.

Both the pre-treatment and post-treatment plasma/serum load of Epstein–Barr viral DNA has been
shown to be of prognostic value [III, B].



Nasopharyngeal cancer chemotherapy drugs

This page has information about the chemotherapy drugs used to treat cancer of the nasopharynx.
There is information about

The drugs you may have

Chemoradiation drugs

How you have chemotherapy

The drugs you may have
It is most common to have two or more chemotherapy drugs together to treat cancer. You may hear
this called combination chemotherapy. Using two or more drugs together is often more effective
than using one drug. The main drugs used in the treatment of nasopharyngeal cancers are

Cisplatin

Fluorouracil (5-FU)

Epirubicin

Other chemotherapy drugs that have been used more recently for nasopharyngeal cancers include

Docetaxel (Taxotere)

Paclitaxel (Taxol)

These links will take you to information about the specific side effects of each drug.

Chemoradiation drugs

If you have stage 3 or 4 nasopharyngeal cancer you are likely to have chemotherapy and
radiotherapy at the same time (known as chemoradiation or synchronous treatment). Some people
with stage 2 nasopharyngeal cancer may also have this treatment. You may have one of the
following

Cisplatin

Cisplatin and 5FU

Carboplatin

Paclitaxel (Taxol)

Docetaxel (Taxotere)

Some of this treatment is experimental and you may have it as part of a clinical trial. Doctors use the
results from clinical trials to improve treatment for head and neck cancers in the future. There is
information about the side effects of chemoradiation on the next page in this section.

How you have chemotherapy

You usually have chemotherapy as cycles of treatment. You have these drugs through a drip
(intravenous infusion) into your arm, usually once every 3 or 4 weeks. Or you may have the drugs
through a tube going into your chest called a central line or portacath. Each 3 or 4 week period is
known as one cycle of treatment. You will probably have between 3 and 4 cycles to begin with. If the
treatment is working and you’re not having too many side effects you will probably go on to have up
to 6 cycles. Your own doctor will decide the exact amount and number of treatments you have. So
the complete chemotherapy course can take 6 months or more.

Sumber
http://cancerhelp.cancerresearchuk.org/type/nasopharyngeal-
cancer/treatment/chemotherapy/nasopharyngeal-cancer-chemotherapy-drugs#drugs

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Radioterapi and chemotherapy plan

  • 1. Radioterapi and Chemotherapy plan A. Darah 1. Blood count : a. Leucosite b. Haemoglobin c. Thrombosite 2. Fungsi hati 3. Fungsi ginjal – creatinin clearence ( tampung urine 24 jam ) 4. Kadar Gula Darah Puasa dan 2 jam pp B. Foto 1. X ray foto Thorax 2. CT Scan Nasofaring C. Biopsi 1. Insisi biopsi tumor 2. Aspirasi biopsi kelenjar getah bening Therapy Follow-up Follow-up for patients includes the following: 1. Routine periodic examination of the original tumor site and neck. 2. CT or PET-CT scan. 3. MRI scan. 4. Blood work. 5. EBV titers. 6. Monitoring of patients should include the following: Surveillance of thyroid and pituitary function. Dental and oral hygiene. Jaw exercises to avoid trismus. 7. Evaluation of cranial nerve function, especially as it relates to vision and hearing.
  • 2. 8. Evaluation of systemic complaints to identify distant metastasis. Although most recurrences occur within 5 years of diagnosis, relapse can be seen at longer intervals. The incidence of second primary malignancies is less than after treatment of tumors at other head and neck sites.[11] Poorly differentiated squamous cell cancer has been associated with EBV antibodies.[4,12] High-titer antibodies to virus capsid antigen and early antigen, especially of high IgA class, or high titers that persist after therapy, have been associated with a poorer prognosis.[13] This finding remains under evaluation. Tumors of many histologies can occur in the nasopharynx, but this discussion, like the American Joint Committee on Cancer nasopharynx staging, refers exclusively to WHO grade I-, II-, and III-type nasopharyngeal carcinoma. Routine staging procedures include: history, physical examination including cranial nerve examination, complete blood cell count, serum biochemistry (including liver function test), chest X-ray, nasopharyngoscopy, computed tomography (CT) scan or magnetic resonance imaging (MRI) of nasopharynx and base of skull and neck. MRI is preferred if available [III, B]. Imaging for distant metastases including isotope bone scan and CT scan of chest and upper abdomen could be considered for at-risk subsets (node positive, especially N3 stage) and for those patients with clinical or biochemical abnormalities detected [III, B]. The use of positron emission tomography is under investigation and findings seem promising. Both the pre-treatment and post-treatment plasma/serum load of Epstein–Barr viral DNA has been shown to be of prognostic value [III, B]. Nasopharyngeal cancer chemotherapy drugs This page has information about the chemotherapy drugs used to treat cancer of the nasopharynx. There is information about The drugs you may have Chemoradiation drugs How you have chemotherapy The drugs you may have
  • 3. It is most common to have two or more chemotherapy drugs together to treat cancer. You may hear this called combination chemotherapy. Using two or more drugs together is often more effective than using one drug. The main drugs used in the treatment of nasopharyngeal cancers are Cisplatin Fluorouracil (5-FU) Epirubicin Other chemotherapy drugs that have been used more recently for nasopharyngeal cancers include Docetaxel (Taxotere) Paclitaxel (Taxol) These links will take you to information about the specific side effects of each drug. Chemoradiation drugs If you have stage 3 or 4 nasopharyngeal cancer you are likely to have chemotherapy and radiotherapy at the same time (known as chemoradiation or synchronous treatment). Some people with stage 2 nasopharyngeal cancer may also have this treatment. You may have one of the following Cisplatin Cisplatin and 5FU Carboplatin Paclitaxel (Taxol) Docetaxel (Taxotere) Some of this treatment is experimental and you may have it as part of a clinical trial. Doctors use the results from clinical trials to improve treatment for head and neck cancers in the future. There is information about the side effects of chemoradiation on the next page in this section. How you have chemotherapy You usually have chemotherapy as cycles of treatment. You have these drugs through a drip (intravenous infusion) into your arm, usually once every 3 or 4 weeks. Or you may have the drugs through a tube going into your chest called a central line or portacath. Each 3 or 4 week period is known as one cycle of treatment. You will probably have between 3 and 4 cycles to begin with. If the treatment is working and you’re not having too many side effects you will probably go on to have up to 6 cycles. Your own doctor will decide the exact amount and number of treatments you have. So the complete chemotherapy course can take 6 months or more. Sumber