23. FIGO stage (2000) Anatomical stage All other metastatic sites. IV Disease extend to lung with or without genital tract involvement. III Disease extend outside uterus, but limited to genital structures. II Disease confined to the uterus. I
24. FIGO stage (2000) Risk score (modified WHO) Two or more Single - - Previous failed chemotherapy >8 5-8 1-4 - Number of metastasis Liver, brain Gastro-intestinal Spleen, kidney Lung Site of metastasis - ≥ 5 3-<5 <3 Largest tumor size (cm) ≥ 10 5 10 4 -<10 5 10 3 -<10 4 <10 3 Pre-treatment hCG (IU/l) ≥ 13 7-<13 4-<7 <4 Interval from index preg. (mos) Term Abortion Mole Antecedent pregnancy - - ≥ 40 <40 Age (yrs) 4 2 1 0 score
30. Single drug regimen 14 200 mg/m 2 oral x 5 days Etoposide - 30 mg/kg/d continuous 10 day infusion 5 FU 14 -10 µg/kg IV x 5 days -1.25 mg/m 2 IV Actinomycin D 14 7-14 - 1 mg/kg day 1,3,5,7 with folinic acid 0.1 mg/kg day 2,4,6,8 - 20-25 mg (0.4 mg/kg) IM x 5 days MTX Duration (days) Dose Drug