Understanding Sevoflurane's Properties and Advantages in Neuroanesthesia
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2. Lesson objectives Understand the history of Sevoflurane Recognize the pharmacological properties of Sevoflurane Recognize its specific advantages in neuroanaesthesia Must appreciate unfavourable conditions produced by Sevoflurane
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4. Past 50 years- 3 gases,13 inhalational anaesthetics were introduced.
56. Conclusions Cerebral autoregulation maintained Coupling of metabolism and o2 demand maintained Rapid recovery and early neurological assessment possible Pre-conditioning of the brain for ischemic attacks Protects brain cells Non-inflammable No long term effects on vital organs Maintains co2 reactivity
60. Direct Cerebral Vasodilatory Effects of SevofluraneandIsofluraneBasil F. Matta, M.B.B.Ch., B.A., F.R.C.A.,* Karen J. Heath, M.B.B.S., F.R.C.A.,† Kate Tipping, M.B.B.S.,‡ Andrew C. Summors, B.Sc., M.B.B.S., F.R.C.A.‡ *
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63. The Effects of Prolonged Low-Flow Sevoflurane Anesthesia on Renal and Hepatic Function Ryoji Obata, MD, HiromichiBito, MD, Morihiro Ohmura, GorokuMoriwaki, MD, YukakoIkeuchi, MD, TakasumiKatoh, MD, and Shigehito Sato, MD Department of Anesthesiology and Intensive Care, Hamamatsu University School of Medicine, Hamamatsu, Japan
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66. Low-flow Sevoflurane Compared with Low-flow Isoflurane Anesthesia in Patients with Stable Renal InsufficiencyPeter F. Conzen, M.D.,* Evan D. Kharasch, M.D., Ph.D.,† Stephan F. A. Czerner, M.D.,‡ Alan A. Artru, M.D.,†Florian M. Reichle, M.D.,‡ PiotrMichalowski, M.D., Ph.D.,§ G. Alec Rooke, M.D., Ph.D.,_ Branko M. Weiss, M.D.,# Thomas J. Ebert, M.D., Ph.D.**