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Common Physical Symptoms




    Website: http://ivmsicm.blogspot.com/
                                            1
Common Physical
          Symptoms
          Marc Imhotep Cray, M.D.
           Companion Online Folder:
IVMS-Physical Diagnosis Notes and Reference Resources
Objectives
• Know general guidelines for managing
  nonpain symptoms
• Understand how the principles of intended /
  unintended consequences and double effect
  apply to symptom management
• Know the assessment, management of
  common physical symptoms


                                                3
General management guidelines
             ...
• History, physical examination
• Conceptualize likely causes
• Discuss treatment options, assist with decision
  making



                                               4
Breathlessness (dyspnea) . . .
• May be described as
  – shortness of breath
  – a smothering feeling
  – inability to get enough air
  – suffocation


                                  5
. . . Breathlessness (dyspnea)
• The only reliable measure is patient self-report
• Respiratory rate, pO2, blood gas
  determinations DO NOT correlate with the
  feeling of breathlessness
• Prevalence in the life-threateningly ill: 12 –
  74%

                                                 6
Causes of breathlessness
•   Anxiety              •   Pulmonary embolism
•   Airway obstruction   •   Thick secretions
•   Bronchospasm         •   Anemia
•   Hypoxemia            •   Metabolic
•   Pleural effusion     •   Family / financial / legal
•   Pneumonia                / spiritual / practical
•   Pulmonary edema          issues

                                                          7
Management
           of breathlessness
• Treat the underlying cause
• Symptomatic management
  – oxygen
  – opioids
  – anxiolytics
  – nonpharmacologic interventions




                                     8
Oxygen
•   Pulse oximetry not helpful
•   Potent symbol of medical care
•   Expensive
•   Fan may do just as well




                                    9
Opioids
•   Relief not related to respiratory rate
•   No ethical or professional barriers
•   Small doses
•   Central and peripheral action




                                             10
Anxiolytics
• Safe in combination with opioids
  – lorazepam
     • 0.5-2 mg po q 1 h prn until settled
     • then dose routinely q 4–6 h to keep settled




                                                     11
Nonpharmacologic interventions
            ...
• Reassure, work to manage anxiety
• Behavioral approaches, eg, relaxation,
  distraction, hypnosis
• Limit the number of people in the room
• Open window


                                           12
Nonpharmacologic interventions
            ...
•   Eliminate environmental irritants
•   Keep line of sight clear to outside
•   Reduce the room temperature
•   Avoid chilling the patient



                                          13
. . . Nonpharmacologic
              interventions
• Introduce humidity
• Reposition
  – elevate the head of the bed
  – move patient to one side or other
• Educate, support the family




                                        14
Nausea / vomiting
• Nausea
  – subjective sensation
  – stimulation
     • gastrointestinal lining, CTZ, vestibular apparatus,
       cerebral cortex
• Vomiting
  – neuromuscular reflex



                                                             15
Causes
           of nausea / vomiting
•   Metastases
                            Mechanical
•   Meningeal irritation     obstruction
•   Movement                Motility
•   Mental anxiety          Metabolic
•   Medications             Microbes
•   Mucosal irritation      Myocardial

                                           16
Pathophysiology
        of nausea / vomiting

  Chemoreceptor
Trigger Zone (CTZ)

     Vomiting center

Neurotransmitters
 Serotonin
 Dopamine
 Acetylcholine
 Histamine
                               17
Management
             of nausea / vomiting


•   Dopamine antagonists    •   Prokinetic agents
•   Antihistamines          •   Antacids
•   Anticholinergics        •   Cytoprotective agents
•   Serotonin antagonists   •   Other medications



                                                        18
Dopamine antagonists
•   Haloperidol
•   Prochlorperazine
•   Droperidol
•   Thiethylperazine
•   Promethazine
•   Perphenazine
•   Trimethobenzamide
•   Metoclopramide
                            19
Histamine antagonists
           (antihistamines)
• Diphenhydramine
• Meclizine
• Hydroxyzine




                              20
Acetylcholine antagonists
                (anticholinergics)
• Scopolamine




                                     21
Serotonin antagonists
• Ondansetron
• Granisetron




                             22
Prokinetic agents
• Metoclopramide
• Cisapride




                            23
Antacids

• Antacids
• H2 receptor antagonists
  – cimetidine
  – famotidine
  – ranitidine
• Proton pump inhibitors
  – omeprazole
  – lansoprazole


                            24
Cytoprotective agents
• Misoprostol
• Proton pump inhibitors (omeprazole,
  lansoprazole)




                                        25
Other medications

•   Dexamethasone
•   Tetrahydrocannabinol
•   Lorazepam
•   Octreotide




                           26
Constipation
• Medications           • Metabolic
    – opioids             abnormalities
    – calcium-channel
                        • Spinal cord
      blockers
    – anticholinergic
                          compression
• Decreased motility    • Dehydration
• Ileus                 • Autonomic
                          dysfunction
• Mechanical
  obstruction           • Malignancy


                                          27
Management
            of constipation
• General measures       • Specific measures
   –establish what is       – stimulants
    “normal”                – osmotics
   –regular toileting       – detergents
   –gastrocolic reflex      – lubricants
                            – large volume
                              enemas

                                               28
Stimulant laxatives
•   Prune juice
•   Senna
•   Casanthranol
•   Bisacodyl




                                29
Osmotic laxatives
• Lactulose or sorbitol
• Milk of magnesia (other Mg salts)
• Magnesium citrate




                                      30
Detergent laxatives
           (stool softeners)
• Sodium docusate
• Calcium docusate
• Phosphosoda enema prn




                               31
Prokinetic agents
• Metoclopramide
• Cisapride




                            32
Lubricant stimulants
• Glycerin suppositories
• Oils
  – mineral
  – peanut




                              33
Large-volume enemas
• Warm water
• Soap suds




                           34
Constipation
            from opioids . . .
• Occurs with all opioids
• Pharmacologic tolerance developed slowly, or
  not at all
• Dietary interventions alone usually not
  sufficient
• Avoid bulk-forming agents in debilitated
  patients


                                                 35
. . . Constipation
               from opioids
• Combination stimulant / softeners are useful
  first-line medications
  – casanthranol + docusate sodium
  – senna + docusate sodium
• Prokinetic agents




                                                 36
Causes of diarrhea

•   Infections
•   GI bleeding
•   Malabsorption
•   Medications
•   Obstruction
•   Overflow incontinence
•   Stress

                            37
Management of diarrhea
•   Establish normal bowel pattern
•   Avoid gas-forming foods
•   Increase bulk
•   Transient, mild diarrhea
    – attapulgite
    – bismuth salts



                                     38
Management
          of persistent diarrhea
•   Loperamide
•   Diphenoxylate / atropine
•   Tincture of opium
•   Octreotide




                                   39
Anorexia / cachexia
• Loss of appetite
• Loss of weight




                              40
Management
     of anorexia / cachexia . . .
• Assess, manage comorbid conditions
• Educate, support
• Favorite foods / nutritional supplements




                                             41
. . . Management
         of anorexia / cachexia
•   Alcohol
•   Dexamethasone
•   Megestrol acetate
•   Tetrahydrocannabinol (THC)
•   Androgens




                                  42
Management
        of fatigue / weakness . . .
•   Promote energy conservation
•   Evaluate medications
•   Optimize fluid, electrolyte intake
•   Permission to rest
•   Clarify role of underlying illness
•   Educate, support patient, family
•   Include other disciplines

                                         43
. . . Management
         of fatigue / weakness
• Dexamethasone
  – feeling of well-being, increased energy
  – effect may wane after 4-6 weeks
  – continue until death
• Methylphenidate




                                              44
Fluid balance / edema . . .
• Frequently associated with advanced illness
• Hypoalbuminemia  decreased oncotic
  pressure
• Venous or lymphatic obstruction may
  contribute




                                                45
. . . Fluid balance / edema
•   Limit or avoid IV fluids
•   Urine output will be low
•   Drink some fluids with salt
•   Fragile skin




                                   46
Skin
• Hygiene
• Protection
• Support




                      47
Pressure (decubitus) ulcers
•   Prolonged pressure
•   Inactivity
•   Closely associated with mortality
•   Easier to prevent than treat




                                        48
Odors

• Topical and / or systemic antibiotics
    – metronidazole
    – silver sulfadiazine
•   Kitty litter
•   Activated charcoal
•   Vinegar
•   Burning candles

                                          49
Insomnia
• Assessment of sleep
• Other unrelieved symptoms
• Use family to help assess




                              50
Management
               of insomnia . . .
•   Regular sleep schedule, avoid staying in bed
•   Avoid caffeine, assess alcohol intake
•   Cognitive / physical stimulation
•   Avoid overstimulation
•   Control pain during the night
•   Relaxation, imagery



                                                   51
. . . Management
                  of insomnia
•   Antihistamines
•   Benzodiazepines
•   Neuroleptics
•   Sedating antidepressant (trazodone)
•   Careful titration
•   Attention to adverse effects



                                          52
Reference Resource Folder:
IVMS-Medical Teacher Articles

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IVMS -ICM COMMON SIGNS AND SYMPTOMS

  • 1. Common Physical Symptoms Website: http://ivmsicm.blogspot.com/ 1
  • 2. Common Physical Symptoms Marc Imhotep Cray, M.D. Companion Online Folder: IVMS-Physical Diagnosis Notes and Reference Resources
  • 3. Objectives • Know general guidelines for managing nonpain symptoms • Understand how the principles of intended / unintended consequences and double effect apply to symptom management • Know the assessment, management of common physical symptoms 3
  • 4. General management guidelines ... • History, physical examination • Conceptualize likely causes • Discuss treatment options, assist with decision making 4
  • 5. Breathlessness (dyspnea) . . . • May be described as – shortness of breath – a smothering feeling – inability to get enough air – suffocation 5
  • 6. . . . Breathlessness (dyspnea) • The only reliable measure is patient self-report • Respiratory rate, pO2, blood gas determinations DO NOT correlate with the feeling of breathlessness • Prevalence in the life-threateningly ill: 12 – 74% 6
  • 7. Causes of breathlessness • Anxiety • Pulmonary embolism • Airway obstruction • Thick secretions • Bronchospasm • Anemia • Hypoxemia • Metabolic • Pleural effusion • Family / financial / legal • Pneumonia / spiritual / practical • Pulmonary edema issues 7
  • 8. Management of breathlessness • Treat the underlying cause • Symptomatic management – oxygen – opioids – anxiolytics – nonpharmacologic interventions 8
  • 9. Oxygen • Pulse oximetry not helpful • Potent symbol of medical care • Expensive • Fan may do just as well 9
  • 10. Opioids • Relief not related to respiratory rate • No ethical or professional barriers • Small doses • Central and peripheral action 10
  • 11. Anxiolytics • Safe in combination with opioids – lorazepam • 0.5-2 mg po q 1 h prn until settled • then dose routinely q 4–6 h to keep settled 11
  • 12. Nonpharmacologic interventions ... • Reassure, work to manage anxiety • Behavioral approaches, eg, relaxation, distraction, hypnosis • Limit the number of people in the room • Open window 12
  • 13. Nonpharmacologic interventions ... • Eliminate environmental irritants • Keep line of sight clear to outside • Reduce the room temperature • Avoid chilling the patient 13
  • 14. . . . Nonpharmacologic interventions • Introduce humidity • Reposition – elevate the head of the bed – move patient to one side or other • Educate, support the family 14
  • 15. Nausea / vomiting • Nausea – subjective sensation – stimulation • gastrointestinal lining, CTZ, vestibular apparatus, cerebral cortex • Vomiting – neuromuscular reflex 15
  • 16. Causes of nausea / vomiting • Metastases  Mechanical • Meningeal irritation obstruction • Movement  Motility • Mental anxiety  Metabolic • Medications  Microbes • Mucosal irritation  Myocardial 16
  • 17. Pathophysiology of nausea / vomiting Chemoreceptor Trigger Zone (CTZ) Vomiting center Neurotransmitters  Serotonin  Dopamine  Acetylcholine  Histamine 17
  • 18. Management of nausea / vomiting • Dopamine antagonists • Prokinetic agents • Antihistamines • Antacids • Anticholinergics • Cytoprotective agents • Serotonin antagonists • Other medications 18
  • 19. Dopamine antagonists • Haloperidol • Prochlorperazine • Droperidol • Thiethylperazine • Promethazine • Perphenazine • Trimethobenzamide • Metoclopramide 19
  • 20. Histamine antagonists (antihistamines) • Diphenhydramine • Meclizine • Hydroxyzine 20
  • 21. Acetylcholine antagonists (anticholinergics) • Scopolamine 21
  • 24. Antacids • Antacids • H2 receptor antagonists – cimetidine – famotidine – ranitidine • Proton pump inhibitors – omeprazole – lansoprazole 24
  • 25. Cytoprotective agents • Misoprostol • Proton pump inhibitors (omeprazole, lansoprazole) 25
  • 26. Other medications • Dexamethasone • Tetrahydrocannabinol • Lorazepam • Octreotide 26
  • 27. Constipation • Medications • Metabolic – opioids abnormalities – calcium-channel • Spinal cord blockers – anticholinergic compression • Decreased motility • Dehydration • Ileus • Autonomic dysfunction • Mechanical obstruction • Malignancy 27
  • 28. Management of constipation • General measures • Specific measures –establish what is – stimulants “normal” – osmotics –regular toileting – detergents –gastrocolic reflex – lubricants – large volume enemas 28
  • 29. Stimulant laxatives • Prune juice • Senna • Casanthranol • Bisacodyl 29
  • 30. Osmotic laxatives • Lactulose or sorbitol • Milk of magnesia (other Mg salts) • Magnesium citrate 30
  • 31. Detergent laxatives (stool softeners) • Sodium docusate • Calcium docusate • Phosphosoda enema prn 31
  • 33. Lubricant stimulants • Glycerin suppositories • Oils – mineral – peanut 33
  • 34. Large-volume enemas • Warm water • Soap suds 34
  • 35. Constipation from opioids . . . • Occurs with all opioids • Pharmacologic tolerance developed slowly, or not at all • Dietary interventions alone usually not sufficient • Avoid bulk-forming agents in debilitated patients 35
  • 36. . . . Constipation from opioids • Combination stimulant / softeners are useful first-line medications – casanthranol + docusate sodium – senna + docusate sodium • Prokinetic agents 36
  • 37. Causes of diarrhea • Infections • GI bleeding • Malabsorption • Medications • Obstruction • Overflow incontinence • Stress 37
  • 38. Management of diarrhea • Establish normal bowel pattern • Avoid gas-forming foods • Increase bulk • Transient, mild diarrhea – attapulgite – bismuth salts 38
  • 39. Management of persistent diarrhea • Loperamide • Diphenoxylate / atropine • Tincture of opium • Octreotide 39
  • 40. Anorexia / cachexia • Loss of appetite • Loss of weight 40
  • 41. Management of anorexia / cachexia . . . • Assess, manage comorbid conditions • Educate, support • Favorite foods / nutritional supplements 41
  • 42. . . . Management of anorexia / cachexia • Alcohol • Dexamethasone • Megestrol acetate • Tetrahydrocannabinol (THC) • Androgens 42
  • 43. Management of fatigue / weakness . . . • Promote energy conservation • Evaluate medications • Optimize fluid, electrolyte intake • Permission to rest • Clarify role of underlying illness • Educate, support patient, family • Include other disciplines 43
  • 44. . . . Management of fatigue / weakness • Dexamethasone – feeling of well-being, increased energy – effect may wane after 4-6 weeks – continue until death • Methylphenidate 44
  • 45. Fluid balance / edema . . . • Frequently associated with advanced illness • Hypoalbuminemia  decreased oncotic pressure • Venous or lymphatic obstruction may contribute 45
  • 46. . . . Fluid balance / edema • Limit or avoid IV fluids • Urine output will be low • Drink some fluids with salt • Fragile skin 46
  • 48. Pressure (decubitus) ulcers • Prolonged pressure • Inactivity • Closely associated with mortality • Easier to prevent than treat 48
  • 49. Odors • Topical and / or systemic antibiotics – metronidazole – silver sulfadiazine • Kitty litter • Activated charcoal • Vinegar • Burning candles 49
  • 50. Insomnia • Assessment of sleep • Other unrelieved symptoms • Use family to help assess 50
  • 51. Management of insomnia . . . • Regular sleep schedule, avoid staying in bed • Avoid caffeine, assess alcohol intake • Cognitive / physical stimulation • Avoid overstimulation • Control pain during the night • Relaxation, imagery 51
  • 52. . . . Management of insomnia • Antihistamines • Benzodiazepines • Neuroleptics • Sedating antidepressant (trazodone) • Careful titration • Attention to adverse effects 52