This study examines the prevalence of metabolic syndrome in the US population using data from the Third National Health and Nutrition Examination Survey (NHANES III). The metabolic syndrome was present in 22.8% of US men and 22.6% of US women. The prevalence was highest in Mexican Americans and lowest in blacks of both sexes. Several demographic and lifestyle factors were associated with increased odds of metabolic syndrome, including older age, higher BMI, smoking, low income, high carbohydrate intake, no alcohol consumption, and physical inactivity.