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Prepared By:
Montalbo, Daniel Justin B.
De Castro, Ralph Louis R.
   Mendel’s Law of Segregation states that there are two alleles
    for every gene determining a specific characteristic, and these
    alleles are segregated into separate gametes during
    reproduction.
   When the 2 different alleles occur together in one individual
    (heterozygote), the dominant allele will be the one that is
    expressed in the phenotype of the individual.
   The Law of Addition is used to combine probabilities, when
    there are 2 or more ways to arrive at a given outcome.
   The Law of Multiplication is used to combine probabilities of 2
    or more different events that need to occur in combination.
   Mendel’s Law of Independent Assortment says that 2 or
    more different genes, if found on separate chromosomes, are
    determined independently of each other.
   Many characteristics have been found to follow patterns of
    inheritance that are modifications of Mendel’s rules.
• pure               • forked line
•   gene          breeding           • polygenes
•   allele      • hybrid             • contributor
•   dominant    • homozygous           y allele
•   recessive   • heterozygous       • non-
                                       contributor
•   character   • P (parental
                                       y allele
                  generation)
•   trait                            • continuous
                • F1 (first filial     variation
•   phenotyp
                  generation)        • discontinuo
    e
                • F2 (second           us variation
•   genotype
                  filial
                  generation)
                • Punnett
CHARACTERS   TRAITS




•   Pre-Mendel beliefs in
    genetics: blending
    theory
•   Augustinian monk and
    science teacher
•   Why Pisum sativum?
    – Pea plants available in
      many varieties
      • character (heritable feature)
      • trait (character variant)
    – Perfect flowers
      • cross-pollination and
        self-pollination
    – Short generation time
    – Many offspring
MONOHYBRID CROSS
inheritance of a single trait

 P Generation
 (true-breeding
                                 x
    parents)
                        Purple        White
                       flowers       flowers




 F1 Generation
    (hybrids)
                          All plants had
                          purple flowers
                                     self-pollination


 F2 Generation




                 705 plants          224 plants
Allele for purple flowers
                                               Alternative versions
                                                of genes exist
                              Homologous
                                                (alleles)
Locus for flower-color gene   pair of           › Dominant
                              chromosomes
                                                › Recessive
                                               Organism inherites
    Allele for white flowers                    2 alleles
                                                › Dominant is fully
                                                  expressed
                                                › Recessive has no
                                                  visible effect
                                               Law of segregation
                                                › 2 alleles for one
                                                  character
                                                  separate and go
                                                  to different
                                                  gametes
True-breeding plants have identical           P Generation
alleles.                                                                                    x
                                                                    Purple flowers              White flowers
Gametes each contain only one allele                                      PP                         pp
for the flower-color gene. Every gamete          Appearance:
produced by one parent has the same allele.      Genetic makeup:
                                                                                 P                        p
                                               Gametes:

F1 hybrids have a Pp combination.
Purple-flower allele is dominant,             F1 Generation
all hybrids have purple flowers.
                                                                                     Purple flowers
Hybrid plants produce gametes,                    Appearance:
                                                  Genetic makeup:                          Pp
two alleles segregate: half the
gametes receiving the P allele and
                                                                    1
                                                                        /2       P
                                                                                                 1
                                                                                                     /2   p
                                               Gametes:
the other half the p allele.

Punnett square: shows all possible                                                              F1 sperm
combinations of alleles in offspring                                                  P
                                                                                                 p
from an F1 x F1 (Pp x Pp) cross.              F2 Generation
                                                                    P
Each square represents an equally probable                                           PP         Pp
product of fertilization.                                 F1 eggs
                                                                    p
                                                                                     Pp          pp
Random combination of the gametes
results in the 3:1 ratio that Mendel
                                                                             3            :1
observed in the F2 generation.
• Homozygous –
  identical alleles,
  true-breeding
• Heterozygous –
  different alleles
• Phenotype –
  physical
  appearance
• Genotype –
  genetic make-
  up
APPLICATION

An organism displaying the dominant phenotype can either                                   X
be homozygous or heterozygous for the trait. A test-cross will
help determine which.
                                                                     Dominant phenotype,            Recessive phenotype,
                                                                      unknown genotype:               known genotype:
 TECHNIQUE                                                                PP or Pp?                          pp

 The individual with the unknown genotype is crossed with
 a homozygous individual expressing the recessive trait
 (white flowers in this example). By observing the                                                            If Pp,
                                                                           If PP,
 phenotypes of the offspring resulting from this                                                   then 1⁄2 offspring purple
                                                                     then all offspring
 cross, we can deduce the genotype of the purple-flowered
                                                                         purple:                    and 1⁄2 offspring white:
 parent.
                                                                          p         p                     p          p
 RESULTS
                                                                 P                             P
                                                                        Pp          Pp                   Pp          Pp

                                                                 P                             p
                                                                        Pp         Pp                    pp          pp
 Illustrates the
  inheritance of two
  characters
 Produces four
  phenotypes in the F2
  generation
 Law of Addition -
  combines probabilities
  for mutually exclusive
  events
 The Law of
  Multiplication -
  combines probabilities
  of 2 or more
  independent events
  that need to occur
  together
Forked Line Method




AaBbCc x AaBbCc
1.   Codominance
     –   two dominant alleles affect
         phenotype in separate
         ways
     –   both alleles manifest
     –   e.g. roan coloring in horses
         – both red and white
2.   Incomplete dominance
     –   phenotype of offspring is
         between phenotypes of
         two parents
     –   e.g. red and white parents
         give rise to pink offspring
3.   Multiple alleles
     –   genes with more than two
         alleles that control the
         phenotype
     –   e.g. ABO blood type system
         has 3 alleles--A,B,i. A and B
         are codominant, i is
         recessive to both

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Taboo Rap Gen Lec

  • 1. Prepared By: Montalbo, Daniel Justin B. De Castro, Ralph Louis R.
  • 2. Mendel’s Law of Segregation states that there are two alleles for every gene determining a specific characteristic, and these alleles are segregated into separate gametes during reproduction.  When the 2 different alleles occur together in one individual (heterozygote), the dominant allele will be the one that is expressed in the phenotype of the individual.  The Law of Addition is used to combine probabilities, when there are 2 or more ways to arrive at a given outcome.  The Law of Multiplication is used to combine probabilities of 2 or more different events that need to occur in combination.  Mendel’s Law of Independent Assortment says that 2 or more different genes, if found on separate chromosomes, are determined independently of each other.  Many characteristics have been found to follow patterns of inheritance that are modifications of Mendel’s rules.
  • 3. • pure • forked line • gene breeding • polygenes • allele • hybrid • contributor • dominant • homozygous y allele • recessive • heterozygous • non- contributor • character • P (parental y allele generation) • trait • continuous • F1 (first filial variation • phenotyp generation) • discontinuo e • F2 (second us variation • genotype filial generation) • Punnett
  • 4. CHARACTERS TRAITS • Pre-Mendel beliefs in genetics: blending theory • Augustinian monk and science teacher • Why Pisum sativum? – Pea plants available in many varieties • character (heritable feature) • trait (character variant) – Perfect flowers • cross-pollination and self-pollination – Short generation time – Many offspring
  • 5. MONOHYBRID CROSS inheritance of a single trait P Generation (true-breeding x parents) Purple White flowers flowers F1 Generation (hybrids) All plants had purple flowers self-pollination F2 Generation 705 plants 224 plants
  • 6.
  • 7. Allele for purple flowers  Alternative versions of genes exist Homologous (alleles) Locus for flower-color gene pair of › Dominant chromosomes › Recessive  Organism inherites Allele for white flowers 2 alleles › Dominant is fully expressed › Recessive has no visible effect  Law of segregation › 2 alleles for one character separate and go to different gametes
  • 8. True-breeding plants have identical P Generation alleles. x Purple flowers White flowers Gametes each contain only one allele PP pp for the flower-color gene. Every gamete Appearance: produced by one parent has the same allele. Genetic makeup: P p Gametes: F1 hybrids have a Pp combination. Purple-flower allele is dominant, F1 Generation all hybrids have purple flowers. Purple flowers Hybrid plants produce gametes, Appearance: Genetic makeup: Pp two alleles segregate: half the gametes receiving the P allele and 1 /2 P 1 /2 p Gametes: the other half the p allele. Punnett square: shows all possible F1 sperm combinations of alleles in offspring P p from an F1 x F1 (Pp x Pp) cross. F2 Generation P Each square represents an equally probable PP Pp product of fertilization. F1 eggs p Pp pp Random combination of the gametes results in the 3:1 ratio that Mendel 3 :1 observed in the F2 generation.
  • 9. • Homozygous – identical alleles, true-breeding • Heterozygous – different alleles • Phenotype – physical appearance • Genotype – genetic make- up
  • 10. APPLICATION An organism displaying the dominant phenotype can either X be homozygous or heterozygous for the trait. A test-cross will help determine which. Dominant phenotype, Recessive phenotype, unknown genotype: known genotype: TECHNIQUE PP or Pp? pp The individual with the unknown genotype is crossed with a homozygous individual expressing the recessive trait (white flowers in this example). By observing the If Pp, If PP, phenotypes of the offspring resulting from this then 1⁄2 offspring purple then all offspring cross, we can deduce the genotype of the purple-flowered purple: and 1⁄2 offspring white: parent. p p p p RESULTS P P Pp Pp Pp Pp P p Pp Pp pp pp
  • 11.  Illustrates the inheritance of two characters  Produces four phenotypes in the F2 generation  Law of Addition - combines probabilities for mutually exclusive events  The Law of Multiplication - combines probabilities of 2 or more independent events that need to occur together
  • 12.
  • 14. 1. Codominance – two dominant alleles affect phenotype in separate ways – both alleles manifest – e.g. roan coloring in horses – both red and white 2. Incomplete dominance – phenotype of offspring is between phenotypes of two parents – e.g. red and white parents give rise to pink offspring 3. Multiple alleles – genes with more than two alleles that control the phenotype – e.g. ABO blood type system has 3 alleles--A,B,i. A and B are codominant, i is recessive to both