The journey of the development of the Diabetes Health Profile

1. THE DIABETES HEALTH PROFILE (DHP)
DEVELOPMENT JOURNEY
1986
Initial
development
of the DHP-1
Patient input
25 In-depth patient
interviewsLiterature
review +
DHP Conceptual model
The DHP-1 and DHP-18 are standardised diabetes-specific measures of the impact of diabetes on psychological and
behavioural dysfunctioning in Type 1 and Type 2 diabetes respectively. Compliant with FDA guidelines on PRO developments
for label claims.

2. Through a combination of factor analyses, internal reliability, construct, convergent and discriminant
validity the 32-item DHP-1 conceptual framework is defined for Type 1 & Type 2 Insulin requiring patients.
Compliant with FDA guidelines on PRO developments for label claims.
• Meadows et al 1996; Qual Life Res; 5: 242-254; Goddjin et al. 1996; Qual Life Res; 5: 433-442
1986-1996
DHP-1
Conceptual
framework
development

3. 1996-2000
DHP-18
Conceptual
framework
developed
From the original 32-item DHP-1 the 18-item DHP-18 conceptual framework is derived
for use with Type 1 and Type 2 diabetes including insulin, oral and diet. Compliant with
FDA guidelines on PRO developments for label claims.
• Meadows et al. Diabetic Med 2000; 17: 572-580.

4. Type 1 & Type 2
Respondents
Have completed the
DHP-1 / DHP-18
More than
2000-2013
Current
& previous
users of the
DHP-1/DHP-18

5. 40 45 50 55 60
Oral
Insulin
Disinhibeted
eating
Psycholigical
distress
Barriers to
activity
Score 0=No dysfunctioning p<0.05
0%
10%
20%
30%
40%
50%
60%
70%
80%
90%
100%
35-44 45-54 55-64 65-74 >75
Patients reporting
severe
hypoglycaemic
episodes
Mean
age
63.9
years91% Type 2 and 9% Type 1
patients completed the
questionnaire.
Patients (mean) scores on the
Disinhibited eating domain by
BMI
BMI
<25
BMI
25-34
BMI
>35
55% 45%
47.8
49.2
52.4
Psychological
distress
MOST AT RISK
• Comorbidity
• Severe hypoglycaemia
• Female
• > Age
• Visit to the pyschiatrist
ANOVA p=0.05
An example of what the DHP-1/DHP-18 can tell us
Source: Boini et al. Health and Quality of Life Outcomes; 2010; 8:124
Psychological distress
3173

6. 2013
New
Developments
Investigating the
minimally important
difference of the
Diabetes Health
Profile (DHP-18) and
the EQ-5D and SF-6D
in a UK diabetes
mellitus population
Forthcoming research article
For licensing enquiries contact Isis Outcomes
Email: Healthoutcomes@isis.ox.ac.uk
Tel: : +44 (0)1865 280857
www.isis-innovation.com/outcomes/
For further information on the Diabetes Health Profile visit
www.diabetesprofile.com
Email:info@dhpresearch.com
Copyright DHP Research & Consultancy Ltd 2013 . All rights reserved
Diabetes Health Profile
(DHP) Licensing
Association with
Isis Outcomes.
Develops eDHP