This document summarizes a talk on cloud computing and bioinformatics given by Angel Pizarro. The talk discusses 3 pillars of systems design for cloud computing, 3 storage implementations (S3, distributed file systems on EC2, memory grids), and 3 areas of bioinformatics affected by clouds (computational biology, software engineering, applications to life sciences). It also summarizes 3 internal projects at UPenn related to resource management, workflow management, and an RNA-Seq analysis pipeline called RUM that combines Bowtie and BLAT.