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Dermo epidermal junction

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Shah Janak
Shah Janak

dermatolgy

Gesundheit & MedizinTechnologie
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D ermo – E pidermal J unction Presented by Adel A. Al-Ghamdi Dermatology Department King Fahd Hospital of university
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Introduction
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Origin of Basement Membrane ,[object Object],[object Object],[object Object],[object Object]
Functions of basement membrane ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Ultrastructure of DEJ
WWW.SMSO.NET
Ultrastructure of DEJ ,[object Object],[object Object],DEJ 1 ST ZONE 2 ND ZONE 3 RD ZONE Sub basal lamina Lamina densa Tonofilement, Hemidesmosomes Anchoring filement complexs
First zone ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
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Second zone ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
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Third zone ( the sub basal lamina) ,[object Object],[object Object],[object Object],[object Object]
[object Object],[object Object],[object Object]
[object Object],[object Object],[object Object]
[object Object],[object Object]
WWW.SMSO.NET
Ubiquitous Components of Basement Membrane Type IV collage Laminin Nidogen/Entactin Heparan sulfate proteoglycan
Type IV Collagen ,[object Object],[object Object],[object Object],[object Object]
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[object Object],[object Object],[object Object],[object Object],[object Object]
[object Object],[object Object],[object Object],[object Object]
[object Object],[object Object]
 
WWW.SMSO.NET
WWW.SMSO.NET
Laminin ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
[object Object],[object Object],[object Object]
[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
WWW.SMSO.NET
Nidogen / Entactin ,[object Object],[object Object],[object Object],[object Object]
WWW.SMSO.NET
Heparan sulfate proteoglycan ,[object Object],[object Object],[object Object],[object Object]
Epithelial-Specific Basement membrane Components Hemidesmosome Anchoring filaments Epithelial lamina densa Anchoring fibrils & anchoring plaques
Hemidesmosome (HD) ,[object Object],[object Object],[object Object]
[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
[object Object],[object Object],[object Object],[object Object]
WWW.SMSO.NET
Major Hemidesmosomal Antigens 240-kDa protein BPAG1 180-kDA protein BPAG2 Plectin Integrin alpha6 beta4
BPAG1 ,[object Object],[object Object],[object Object]
BPAG2 ,[object Object],[object Object],[object Object],[object Object]
Plectin ,[object Object],[object Object],[object Object],[object Object],[object Object]
Integrin alpha6 beta4 ,[object Object],[object Object],[object Object],[object Object]
Anchoring filaments ,[object Object],[object Object]
WWW.SMSO.NET
Major Anchoring filament Antigens Laminin 5 125-kDa 19-DEJ-1 105-kDa Ladinin LAD-1
Laminin 5 (alpha3 beta3 gamma 2) ,[object Object],[object Object],[object Object],[object Object],[object Object]
[object Object],[object Object]
125-kDa protein ,[object Object]
19-DEJ-1 antigen ,[object Object],[object Object],[object Object]
105-kDa Antigen ,[object Object],[object Object],[object Object]
Ladinin & LAD-1 ,[object Object],[object Object]
Epithelial Lamina Densa ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
[object Object],[object Object],[object Object],[object Object]
[object Object],[object Object],[object Object],[object Object]
WWW.SMSO.NET
Anchoring fibrils & Anchoring plaques ,[object Object],[object Object],[object Object],[object Object],[object Object]
[object Object],[object Object],[object Object],[object Object]
[object Object],[object Object],[object Object],[object Object]
WWW.SMSO.NET
EBS EBS MD EBS GABEB JEB Herlitz JEB Dystrophic EB WWW.SMSO.NET
WWW.SMSO.NET
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