1. Glucosamine & Chondroitin
Joint support and
protection 90 Capsules
Serving Size: 1 Capsule
• Supports joint structure Glucosamine HCL
Chondroitin Sulphate
500 mg
400 mg
• Prevents cartilage deterioration Key Features:
Well researched joint support formula.
• Relieves joint pain from arthritis Main Indication:
As reported by literature:
• Osteoarthritis.
• Cushions joint tissues • Sports injuries.
• Cartilage regeneration.
Suggested Use:
Joint builders Take one capsule two to three times a
Glucosamine & Chondroitin is chondroitin sulfate and glucosamine, two day with food, or as directed by a
natural components found in the cartilage of joint tissue. Glucosamine qualified health care practitioner. It
will normally take a minimum of two
has a role in producing the fluids and tissues that cushion joints and is
months to see beneficial effects.
necessary for the formation of skin, eyes, bones, tendons, nails,
Cautions:
ligaments and parts of the heart. Chondroitin sulfate is a component of • Consult a health care provider if
proteoglycans, the main components of cartilage. symptoms persist after ongoing
supplementation, if you experience
Arthritis and joint injury gastrointestinal pain or bowel
Glucosamine's effects in joint support and arthritis are backed by movement disturbances, or if allergic
reaction occurs.
extensive research. Glucosamine helps produce lubricating fluid to • Potassium-restricted or kidney
support joint function and helps repair damage to arthritic joints. Clinical disease patients should use
trials with glucosamine have found that it can reduce pain and improve hydrochloride form.
the symptoms of various forms of arthritis. Chondroitin has similar • Exercise caution if allergic to
seafood (shrimp/ crab).
effects. Together, glucosamine and chondroitin sulfate can reduce the • Theoretical risk of elevated insulin
need to take medication for pain relief. Their effects on joint repair can resistance in diabetics.
also benefit those who are suffering from sports injuries. Pregnancy / Nursing: Do not use.
Source:
Natural relief Glucosamine- crustacean shells
Glucosamine and chondroitin sulfate support joint structure and help to Chondroidin Sulphate- bovine.
build connective tissue, protecting against the destruction of cartilage Complementary Products:
from injury or chronic joint disease. Glucosamine & Chondroitin provides Hyaluronic Acid, Lyprinol, MSM
a natural solution for pain relief and joint protection.
Advanced
Orthomolecular Research www.aor.ca
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AOR - 4101 19th Street NE, Calgary, Alberta T2E CURESELF.COM
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2. Glucosamine & Chondroitin
Glucosamine (GS) is composed of two hexosamine sugars that are common in animal cells.
Glucosamine is produced naturally in the body by chondrocytes in cartilage to help maintain and
build healthy joint tissue. The main purpose of glucosamine is to create long chains of modified
disaccharides called glycosaminoglycans (GAGs), which joints and cartilage require for repair. The
GAGs are the main component of proteoglycans (PGs), which along with chondrocytes and
collagen, make up cartilage. Glucosamine is also converted in the body to N-acetyl-glucosamine,
which in turn is critical to the formation of hyaluronic acid. Hyaluronic acid is the central component
of synovial fluid which acts as a lubricant in the joints.
Chondroitin sulphate (CS) is a heterogenous group of glycosaminoglycans. CS functions as a
component of proteoglycans.
The low molecular weight and high solubility of GS enable it to be readily absorbed in the blood
stream (over 90% of an oral dose). Evidence indicates absorption of GS to be via active transport.
GS is rapidly incorporated into articular cartilage. CS on the other hand is absorbed poorly due to
the wide range of chain lengths and molecular weights. Estimations range between 0.8% and 8.5%
absorption of CS intact. The physiological benefits of CS are likely due to the increased availability
of monosaccharide building blocks (glucuronic acid and N-acetyl glucosamine) created by the
hydrolysis of CS during digestion and absorption.
Clinical Applications of Glucosamine and Chondroitin Sulphate
Glucosamine is a very well studied joint-support supplement.
• A review of a number of clinical studies showed that over 90% of patients reported improvement
of symptoms after taking 1 500mg GS daily for 50 days. Arthritis of the shoulder or elbow
responded the best. CS in various formulations produced similar effects. Co-administration of CS
resulted in 72% reduction in the effective dose of NSAIDs required to relieve pain.
• Another study comparing Voltaren (a prescriptive NSAID) with CS showed that Voltaren produced
a prompt reduction in clinical symptoms; however the symptoms reappeared quickly after the
discontinuation of treatment. Patients treated with CS had a slower response to treatment,
although the favorable response remained up to three months after discontinuation of treatment.
• Forty-two patients (aged 35-78) with symptomatic osteoarthritis of the knee received 800mg daily
dose of CS or placebo for 1 year. After 3 months, joint pain was significantly reduced. The
difference in pain reduction became even more marked after 12 months (63% vs 26%; p<0.01).
An Effective Combination
Studies using the combination of chondroitin sulfate and glucosamine have demonstrated its
effectiveness.
• In patients with capsulitis, disk displacement, disk dislocation or painful osteoarthritis of the
temporomandibular joint, 1500 mg of glucosamine and 1200 mg of CS for 12 weeks reduced
pain and joint tenderness, as well as the daily amount of over-the-counter medications required.
• In another study, glucosamine (1500mg/day) and CS (1200 mg/day) reduced pain in patients
with knee osteoarthritis who had been suffering from moderate-to-severe knee pain.
Glucosamine and chondroitin sulphate are two effective nutrients for joint support. Their
combination provides natural relief for joint pain.
Advanced
Orthomolecular Research www.aor.ca
To purchase AOR products online, click here to visit CURESELF.COM
AOR 9 - 4101 19th Street NE, Calgary, Alberta T2E 6X8 Canada
Innovative Research
& Scientific Integrity