1. January 2010 Manish Singh, PhD President and CEO OTC BB: IMUC.OB www.imuc.com
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6. ICT-107: Dendritic Cell-Based Vaccine Targeting Cancer Stem Cells and Tumor Associated Antigens January 2010 Antigens Tumor Expression CSC Expression gp100 Melanoma, brain cancer Trp-2 Melanoma and brain cancer High Her-2/neu Breast, ovarian cancer Medium MAGE-1 Melanoma, brain cancer AIM Breast, ovarian, colon, brain High IL-13aR2 Brain cancer
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8. Summary of Clinical Data: Progression-Free and Overall Survival January 2010 SOC = Standard of care (surgery + radiation + Temozolomide) Newly Diagnosed (16) SOC + ICT-107 Historical Control (SOC) Median PFS (months) 19.0 6.9 Median OS (months) > 21 14.2 % Survival at 12 months 94% 60% % Survival at 21 months 80% 30% Recurrent (3) Median OS (months) 30.5 7.0 (9.2 with Avastin+SOC)