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Stamping	
  Out	
  strategy	
  failed	
  
In	
  order	
  to	
  become	
  one	
  step	
  ahead	
  of	
  an	
  outbreak	
  of	
  high	
  pathogen	
  diseases	
  like	
  the	
  
current	
  H5N2,	
  the	
  veterinary	
  authorities	
  need	
  to	
  stop	
  the	
  outbreak	
  immediately	
  
after	
  the	
  first	
  signals	
  occur.	
  Strict	
  and	
  thorough	
  biosecurity	
  measures	
  are	
  the	
  most	
  
fundamental	
  feature	
  to	
  protect	
  poultry	
  flocks	
  on	
  farms.	
  
A	
  possible	
  outbreak	
  must	
  be	
  recognized	
  in	
  the	
  earliest	
  possible	
  stage,	
  by	
  actively	
  
monitoring	
  the	
  poultry	
  as	
  well	
  as	
  monitoring	
  wild	
  bird	
  populations	
  in	
  the	
  area	
  
surrounding	
  the	
  farm,	
  by	
  imposing	
  strict	
  rules,	
  like	
  the	
  ban	
  on	
  the	
  sale	
  of	
  live	
  
poultry	
  and	
  temporarily	
  banning	
  movement	
  of	
  poultry	
  until	
  strict	
  bio	
  security	
  
measures	
  on	
  all	
  farms	
  are	
  in	
  place.	
  These	
  measures	
  should	
  last	
  until	
  the	
  emergency	
  
response	
  plans	
  are	
  effectuated.	
  
Past	
  outbreaks	
  were	
  managed	
  on	
  the	
  basis	
  of	
  application	
  of	
  a	
  strategy	
  of	
  stamping	
  
out:	
  eradicating	
  all	
  flocks	
  in	
  and	
  around	
  infected	
  farms	
  in	
  order	
  to	
  stop	
  the	
  spread	
  of	
  
highly	
  pathogenic	
  avian	
  influenza	
  virus.	
  This	
  strategy	
  mainly	
  depends	
  on	
  the	
  control	
  
of	
  the	
  movement	
  of	
  contaminated	
  people,	
  vehicles,	
  equipment	
  and	
  products.	
  Strict	
  
and	
  thorough	
  biosecurity	
  is	
  the	
  most	
  fundamental	
  feature	
  of	
  successful	
  eradication	
  
programs.	
  This	
  principle	
  will	
  again	
  be	
  the	
  key	
  to	
  an	
  effective	
  control	
  and	
  eradication	
  
of	
  the	
  virus.	
  
Up	
  to	
  today,	
  all	
  outbreak	
  response	
  strategies	
  were	
  therefore	
  based	
  on	
  the	
  principle	
  
of	
  culling	
  all	
  animals	
  on	
  the	
  infected	
  farm	
  as	
  fast	
  as	
  possible.	
  This	
  strategy	
  is	
  known	
  
as	
  Stamping	
  Out	
  the	
  infection	
  source	
  by	
  culling	
  the	
  entire	
  flock	
  in	
  the	
  shortest	
  
possible	
  time.	
  All	
  the	
  techniques	
  for	
  culling	
  animals	
  are	
  based	
  on	
  that	
  principle	
  and	
  
issues	
  like	
  operational	
  costs;	
  logistics;	
  human	
  resources;	
  and	
  animal	
  welfare	
  are	
  
considered	
  as	
  of	
  a	
  lower	
  priority.	
  
The	
  most	
  well-­‐known	
  large-­‐scale	
  culling	
  techniques	
  based	
  on	
  the	
  principle	
  of	
  
stamping	
  out	
  infections	
  are	
  culling	
  techniques	
  based	
  on	
  using	
  CO2	
  like	
  stable	
  gassing	
  
and	
  container	
  gassing;	
  using	
  low	
  expansion	
  fire	
  fighting	
  foam;	
  and	
  electrocution.	
  
Describing	
  a	
  range	
  of	
  large-­‐scale	
  culling	
  methods,	
  
Bud	
  Malone	
  and	
  Eric	
  Bensoni
	
  (University	
  of	
  Delaware)	
  
come	
  to	
  the	
  conclusion	
  that	
  there	
  is	
  no	
  possible	
  
ideal	
  depopulation	
  concept	
  with	
  carbon	
  dioxide,	
  
and	
  propose	
  water-­‐based	
  firefighting	
  foam	
  instead.	
  
However,	
  applying	
  fire-­‐fighting	
  foam	
  with	
  fine	
  
bubbles	
  method	
  causes	
  the	
  animals	
  to	
  be	
  killed	
  by	
  
occlusion	
  of	
  the	
  trachea.	
  	
  
Although	
  the	
  fire	
  fighting	
  technique	
  can	
  be	
  used	
  to	
  cull	
  large	
  numbers	
  of	
  floor-­‐
reared	
  broilers	
  and	
  turkeys,	
  it	
  is	
  not	
  applicable	
  to	
  cull	
  caged	
  birds.	
  This	
  means	
  that	
  
the	
  birds	
  have	
  to	
  be	
  taken	
  out	
  of	
  their	
  cages,	
  and	
  than	
  transported	
  through	
  the	
  
narrow	
  walkways	
  between	
  the	
  cages	
  and	
  culled,	
  either	
  by	
  electrocution	
  or	
  by	
  CO2	
  in	
  
disposal	
  container,	
  placed	
  outside	
  of	
  the	
  house.	
  Although	
  humans	
  are	
  supposed	
  to	
  
be	
  less	
  susceptible,	
  they	
  can	
  become	
  carrier	
  of	
  the	
  virus.	
  Only	
  the	
  highest	
  level	
  of	
  
biosecurity	
  could	
  prevent	
  the	
  transmission	
  through	
  the	
  humans	
  and	
  materials	
  that	
  
have	
  been	
  in	
  direct	
  contact	
  with	
  infected	
  animals	
  and	
  materials.	
  This	
  means	
  that	
  
contact	
  between	
  responders	
  and	
  animals	
  need	
  to	
  be	
  reduced	
  to	
  the	
  absolute	
  
minimum.	
  
Large-­‐scale	
  response	
  failed	
  in	
  the	
  USA	
  
Without	
  functional	
  culling	
  techniques,	
  the	
  options	
  to	
  effectively	
  and	
  efficiently	
  cull	
  
in	
  average	
  more	
  than	
  925,000	
  chickens	
  per	
  farm	
  (in	
  Iowa,	
  USA)	
  are	
  limited:	
  either	
  
by	
  macerating	
  the	
  chickens	
  alive	
  –	
  or	
  by	
  ventilation	
  shut-­‐down	
  (closing	
  down	
  all	
  
ventilation,	
  placing	
  heaters	
  inside	
  the	
  house,	
  and	
  heat	
  the	
  entire	
  house	
  to	
  a	
  
temperature	
  higher	
  than	
  600	
  C).	
  	
  Although	
  both	
  methods	
  cause	
  death	
  of	
  the	
  birds,	
  it	
  
has	
  not	
  been	
  proven	
  to	
  be	
  effective	
  nor	
  efficient.	
  The	
  primary	
  goal	
  to	
  slowdown	
  
outbreaks	
  and	
  bring	
  it	
  to	
  a	
  complete	
  stop	
  but	
  macerating	
  live	
  birds	
  and	
  killing	
  them	
  
by	
  heat	
  stress	
  and	
  lack	
  of	
  oxygen	
  would	
  be	
  against	
  all	
  International	
  Animal	
  Welfare	
  
standards.	
  Animal	
  welfare	
  specialists	
  in	
  disease	
  control	
  strongly	
  oppose	
  against	
  the	
  
introduction	
  of	
  these	
  most	
  cruel	
  methods	
  of	
  killing	
  poultry	
  and	
  argue	
  that	
  the	
  ban	
  
on	
  these	
  methods	
  should	
  be	
  maintained	
  and	
  alternative	
  methods	
  need	
  to	
  be	
  
considered.	
  
New	
  Anoxia	
  techniques	
  under	
  developing	
  in	
  Germany	
  
Recognizing	
  that	
  new	
  strategies	
  are	
  needed,	
  Applied	
  Veterinary	
  Technologies	
  AVT	
  
Germany	
  developed	
  specialized	
  equipment	
  based	
  on	
  the	
  use	
  of	
  large	
  quantities	
  of	
  
high	
  expansion	
  foam,	
  filled	
  with	
  >98%	
  nitrogen.	
  These	
  Anoxia	
  techniques	
  
extensively	
  reduce	
  the	
  number	
  of	
  responders	
  needed;	
  guarantees	
  the	
  exclusion	
  of	
  
contact;	
  and	
  the	
  operational	
  costs	
  are	
  only	
  a	
  fraction	
  of	
  the	
  costs	
  compared	
  with	
  
existing	
  traditional	
  methods	
  like	
  stable	
  gassing	
  and	
  container	
  gassing.	
  	
  The	
  first	
  
series	
  of	
  machines	
  are	
  commercially	
  available	
  by	
  the	
  end	
  of	
  October	
  2015	
  and	
  the	
  
order	
  book	
  will	
  be	
  open	
  by	
  November	
  2015.	
  For	
  more	
  information,	
  please	
  contact:	
  
Dr.	
  Michiel	
  van	
  Mil	
  
Anoxia	
  Europe	
  BV	
  
Hoge	
  Eng	
  52a,	
  3882	
  TN	
  Putten,	
  	
  
The	
  Netherlands	
  
	
  	
  
Telephone	
  +31-­‐341701687	
  
info@anoxia-­‐europe.com	
  
www.anoxia-­‐europe.com	
  
	
  
	
  
	
  	
  	
  	
  	
  	
  	
  	
  	
  	
  	
  	
  	
  	
  	
  	
  	
  	
  	
  	
  	
  	
  	
  	
  	
  	
  	
  	
  	
  	
  	
  	
  	
  	
  	
  	
  	
  	
  	
  	
  	
  	
  	
  	
  	
  	
  	
  	
  	
  	
  	
  	
  	
  	
  	
  	
  
i	
  http://udel.edu/~ebenson/Depopulation.htm	
  

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Stamping out strategy failed

  • 1. Stamping  Out  strategy  failed   In  order  to  become  one  step  ahead  of  an  outbreak  of  high  pathogen  diseases  like  the   current  H5N2,  the  veterinary  authorities  need  to  stop  the  outbreak  immediately   after  the  first  signals  occur.  Strict  and  thorough  biosecurity  measures  are  the  most   fundamental  feature  to  protect  poultry  flocks  on  farms.   A  possible  outbreak  must  be  recognized  in  the  earliest  possible  stage,  by  actively   monitoring  the  poultry  as  well  as  monitoring  wild  bird  populations  in  the  area   surrounding  the  farm,  by  imposing  strict  rules,  like  the  ban  on  the  sale  of  live   poultry  and  temporarily  banning  movement  of  poultry  until  strict  bio  security   measures  on  all  farms  are  in  place.  These  measures  should  last  until  the  emergency   response  plans  are  effectuated.   Past  outbreaks  were  managed  on  the  basis  of  application  of  a  strategy  of  stamping   out:  eradicating  all  flocks  in  and  around  infected  farms  in  order  to  stop  the  spread  of   highly  pathogenic  avian  influenza  virus.  This  strategy  mainly  depends  on  the  control   of  the  movement  of  contaminated  people,  vehicles,  equipment  and  products.  Strict   and  thorough  biosecurity  is  the  most  fundamental  feature  of  successful  eradication   programs.  This  principle  will  again  be  the  key  to  an  effective  control  and  eradication   of  the  virus.   Up  to  today,  all  outbreak  response  strategies  were  therefore  based  on  the  principle   of  culling  all  animals  on  the  infected  farm  as  fast  as  possible.  This  strategy  is  known   as  Stamping  Out  the  infection  source  by  culling  the  entire  flock  in  the  shortest   possible  time.  All  the  techniques  for  culling  animals  are  based  on  that  principle  and   issues  like  operational  costs;  logistics;  human  resources;  and  animal  welfare  are   considered  as  of  a  lower  priority.   The  most  well-­‐known  large-­‐scale  culling  techniques  based  on  the  principle  of   stamping  out  infections  are  culling  techniques  based  on  using  CO2  like  stable  gassing   and  container  gassing;  using  low  expansion  fire  fighting  foam;  and  electrocution.   Describing  a  range  of  large-­‐scale  culling  methods,   Bud  Malone  and  Eric  Bensoni  (University  of  Delaware)   come  to  the  conclusion  that  there  is  no  possible   ideal  depopulation  concept  with  carbon  dioxide,   and  propose  water-­‐based  firefighting  foam  instead.   However,  applying  fire-­‐fighting  foam  with  fine   bubbles  method  causes  the  animals  to  be  killed  by   occlusion  of  the  trachea.     Although  the  fire  fighting  technique  can  be  used  to  cull  large  numbers  of  floor-­‐ reared  broilers  and  turkeys,  it  is  not  applicable  to  cull  caged  birds.  This  means  that   the  birds  have  to  be  taken  out  of  their  cages,  and  than  transported  through  the   narrow  walkways  between  the  cages  and  culled,  either  by  electrocution  or  by  CO2  in   disposal  container,  placed  outside  of  the  house.  Although  humans  are  supposed  to  
  • 2. be  less  susceptible,  they  can  become  carrier  of  the  virus.  Only  the  highest  level  of   biosecurity  could  prevent  the  transmission  through  the  humans  and  materials  that   have  been  in  direct  contact  with  infected  animals  and  materials.  This  means  that   contact  between  responders  and  animals  need  to  be  reduced  to  the  absolute   minimum.   Large-­‐scale  response  failed  in  the  USA   Without  functional  culling  techniques,  the  options  to  effectively  and  efficiently  cull   in  average  more  than  925,000  chickens  per  farm  (in  Iowa,  USA)  are  limited:  either   by  macerating  the  chickens  alive  –  or  by  ventilation  shut-­‐down  (closing  down  all   ventilation,  placing  heaters  inside  the  house,  and  heat  the  entire  house  to  a   temperature  higher  than  600  C).    Although  both  methods  cause  death  of  the  birds,  it   has  not  been  proven  to  be  effective  nor  efficient.  The  primary  goal  to  slowdown   outbreaks  and  bring  it  to  a  complete  stop  but  macerating  live  birds  and  killing  them   by  heat  stress  and  lack  of  oxygen  would  be  against  all  International  Animal  Welfare   standards.  Animal  welfare  specialists  in  disease  control  strongly  oppose  against  the   introduction  of  these  most  cruel  methods  of  killing  poultry  and  argue  that  the  ban   on  these  methods  should  be  maintained  and  alternative  methods  need  to  be   considered.   New  Anoxia  techniques  under  developing  in  Germany   Recognizing  that  new  strategies  are  needed,  Applied  Veterinary  Technologies  AVT   Germany  developed  specialized  equipment  based  on  the  use  of  large  quantities  of   high  expansion  foam,  filled  with  >98%  nitrogen.  These  Anoxia  techniques   extensively  reduce  the  number  of  responders  needed;  guarantees  the  exclusion  of   contact;  and  the  operational  costs  are  only  a  fraction  of  the  costs  compared  with   existing  traditional  methods  like  stable  gassing  and  container  gassing.    The  first   series  of  machines  are  commercially  available  by  the  end  of  October  2015  and  the   order  book  will  be  open  by  November  2015.  For  more  information,  please  contact:   Dr.  Michiel  van  Mil   Anoxia  Europe  BV   Hoge  Eng  52a,  3882  TN  Putten,     The  Netherlands       Telephone  +31-­‐341701687   info@anoxia-­‐europe.com   www.anoxia-­‐europe.com                                                                                                                       i  http://udel.edu/~ebenson/Depopulation.htm