1. 18 self-developed pesticides without renewal of technical registrations
Tag: China's self-developed pesticides, patent, intellectual property, registration, R&D
Summary: There have been 18 self-developed pesticides by China with expired registrations
of technical as of Nov. 2013
As mentioned above, there have been 18 self-developed pesticides by China with expired
registrations of technical as of Nov. 2013, according to CCM's collected statistics. Among
these, there were 5 fungicides, 5 insecticides, 5 herbicides and 3 growth regulators, according
to CCM’s December issue of Crop Protection China News.
ZJ0712 (Chinese name: Benmijunzhi)
ZJ0712, namely E-2[2-(2,5-dimethyl-phenoxy)-phenylmethyl]-3-methoxy-acrylic acid methyl
ester, was jointly developed by Zhejiang Chem-Tech Group Co., Ltd. (Former name: Zhejiang
Chemical Industry Research Institute, ZCIRI for short) and Zhejiang Hetian Chemical Co., Ltd.
(Zhejiang Hetian) during the 9th Five-year plan period (1995-2000). ZJ0712 is a
methoxyacrylate fungicide with excellent control effect on powdery mildew of wheat and apple,
downy mildew of cucumber, grape and litchi, anthracnose of watermelon and mango, etc. It
stimulates crop growth as well.
According to Mr. Lu, a sales manager from Zhejiang Hetian, the company had achieved
Chinese invention patent (patent number: ZL 03120882.7) and World intention patent
(WO2004084632) for ZJ0712. According to the ICAMA, Zhejiang Hetian had obtained
temporary registration certificates for ZJ0712 technical (98%) and its 10% SC in 2008, but
these two registrations both expired in Aug. 2011 without renewal.
Propamidine
Propamidine, an amidine fungicide with high control effects on downy mildew, phytophthora,
anthracnose, etc. especially gray mold, was innovated and developed in 2004 by Zhang Xing,
professor from Northwest A&F University.
Professor Zhang cooperated with Shaanxi Yangling Pesticide Chemical Industry Co., Ltd.
(Yangling Pesticide) to realize propamidine commercialization in 2004. Two temporary
registrations have been obtained, for propamidine technical (No: LS20040092) and 2% AS (No.
LS20040130) respectively. However, the temporary registrations were not extended due to the
limited promotion of the product in the market, as Yangling Pesticide doesn't have wide sales
channels and sufficient capital for its promotion. Now Professor Zhang is seeking for other
cooperators. Except for propamidine, Professor Zhang also developed a series of propamidine
derivatives which were claimed to be great market potential as fungicides.
Ascomycin (SPRI-2098)

2. Ascomycin, a novel low residue bio-fungicide developed by Shanghai Pesticide Research
Institute (SPRI), is highly effective for the control of botrytis cinerea on various crops, such as
tomato, cucumber, strawberry, eggplant and summer squash.
In Aug. 2004, a company named Shanghai Nanshen Science & Technology Development Co.,
Ltd. registered ascomycin technical (94%) and its 1% EC, according to the ICAMA. In 2007,
the company didn't get the renewal for these registrations any more.
Subsequently, SPRI transferred the property right of ascomycin to Zhejiang Hisun Chemical
Co., Ltd. (Zhejiang Hisun). Then, Zhejiang Hisun obtained two registration certificates of
ascomycin (also 94% technical and 1% EC) in Dec. 2007 and Mar. 2009 respectively.
Whereas, it was frustrated that Zhejiang Hisun gave up the registration renewal in 2010 and
2011 respectively.
ZJ0712 (Chinese name: Benmijunzhi)
ZJ0712, namely E-2[2-(2,5-dimethyl-phenoxy)-phenylmethyl]-3-methoxy-acrylic acid methyl
ester, was jointly developed by Zhejiang Chem-Tech Group Co., Ltd. (Former name: Zhejiang
Chemical Industry Research Institute, ZCIRI for short) and Zhejiang Hetian Chemical Co., Ltd.
(Zhejiang Hetian) during the 9th Five-year plan period (1995-2000). ZJ0712 is a
methoxyacrylate fungicide with excellent control effect on powdery mildew of wheat and apple,
downy mildew of cucumber, grape and litchi, anthracnose of watermelon and mango, etc. It
stimulates crop growth as well.
According to Mr. Lu, a sales manager from Zhejiang Hetian, the company had achieved
Chinese invention patent (patent number: ZL 03120882.7) and World intention patent
(WO2004084632) for ZJ0712. According to the ICAMA, Zhejiang Hetian had obtained
temporary registration certificates for ZJ0712 technical (98%) and its 10% SC in 2008, but
these two registrations both expired in Aug. 2011 without renewal.
Propamidine
Propamidine, an amidine fungicide with high control effects on downy mildew, phytophthora,
anthracnose, etc. especially gray mold, was innovated and developed in 2004 by Zhang Xing,
professor from Northwest A&F University.
Professor Zhang cooperated with Shaanxi Yangling Pesticide Chemical Industry Co., Ltd.
(Yangling Pesticide) to realize propamidine commercialization in 2004. Two temporary
registrations have been obtained, for propamidine technical (No: LS20040092) and 2% AS (No.
LS20040130) respectively. However, the temporary registrations were not extended due to the
limited promotion of the product in the market, as Yangling Pesticide doesn't have wide sales
channels and sufficient capital for its promotion. Now Professor Zhang is seeking for other
cooperators. Except for propamidine, Professor Zhang also developed a series of propamidine

3. derivatives which were claimed to be great market potential as fungicides.
Ascomycin (SPRI-2098)
Ascomycin, a novel low residue bio-fungicide developed by Shanghai Pesticide Research
Institute (SPRI), is highly effective for the control of botrytis cinerea on various crops, such as
tomato, cucumber, strawberry, eggplant and summer squash.
In Aug. 2004, a company named Shanghai Nanshen Science & Technology Development Co.,
Ltd. registered ascomycin technical (94%) and its 1% EC, according to the ICAMA. In 2007,
the company didn't get the renewal for these registrations any more.
Subsequently, SPRI transferred the property right of ascomycin to Zhejiang Hisun Chemical
Co., Ltd. (Zhejiang Hisun). Then, Zhejiang Hisun obtained two registration certificates of
ascomycin (also 94% technical and 1% EC) in Dec. 2007 and Mar. 2009 respectively.
Whereas, it was frustrated that Zhejiang Hisun gave up the registration renewal in 2010 and
2011 respectively.
ZJ0712 (Chinese name: Benmijunzhi)
ZJ0712, namely E-2[2-(2,5-dimethyl-phenoxy)-phenylmethyl]-3-methoxy-acrylic acid methyl
ester, was jointly developed by Zhejiang Chem-Tech Group Co., Ltd. (Former name: Zhejiang
Chemical Industry Research Institute, ZCIRI for short) and Zhejiang Hetian Chemical Co., Ltd.
(Zhejiang Hetian) during the 9th Five-year plan period (1995-2000). ZJ0712 is a
methoxyacrylate fungicide with excellent control effect on powdery mildew of wheat and apple,
downy mildew of cucumber, grape and litchi, anthracnose of watermelon and mango, etc. It
stimulates crop growth as well.
According to Mr. Lu, a sales manager from Zhejiang Hetian, the company had achieved
Chinese invention patent (patent number: ZL 03120882.7) and World intention patent
(WO2004084632) for ZJ0712. According to the ICAMA, Zhejiang Hetian had obtained
temporary registration certificates for ZJ0712 technical (98%) and its 10% SC in 2008, but
these two registrations both expired in Aug. 2011 without renewal.
Propamidine
Propamidine, an amidine fungicide with high control effects on downy mildew, phytophthora,
anthracnose, etc. especially gray mold, was innovated and developed in 2004 by Zhang Xing,
professor from Northwest A&F University.
Professor Zhang cooperated with Shaanxi Yangling Pesticide Chemical Industry Co., Ltd.
(Yangling Pesticide) to realize propamidine commercialization in 2004. Two temporary
registrations have been obtained, for propamidine technical (No: LS20040092) and 2% AS (No.
LS20040130) respectively. However, the temporary registrations were not extended due to the

4. limited promotion of the product in the market, as Yangling Pesticide doesn't have wide sales
channels and sufficient capital for its promotion. Now Professor Zhang is seeking for other
cooperators. Except for propamidine, Professor Zhang also developed a series of propamidine
derivatives which were claimed to be great market potential as fungicides.
Ascomycin (SPRI-2098)
Ascomycin, a novel low residue bio-fungicide developed by Shanghai Pesticide Research
Institute (SPRI), is highly effective for the control of botrytis cinerea on various crops, such as
tomato, cucumber, strawberry, eggplant and summer squash.
In Aug. 2004, a company named Shanghai Nanshen Science & Technology Development Co.,
Ltd. registered ascomycin technical (94%) and its 1% EC, according to the ICAMA. In 2007,
the company didn't get the renewal for these registrations any more.
Subsequently, SPRI transferred the property right of ascomycin to Zhejiang Hisun Chemical
Co., Ltd. (Zhejiang Hisun). Then, Zhejiang Hisun obtained two registration certificates of
ascomycin (also 94% technical and 1% EC) in Dec. 2007 and Mar. 2009 respectively.
Whereas, it was frustrated that Zhejiang Hisun gave up the registration renewal in 2010 and
2011 respectively.
Pyribambenz-propyl (ZJ0273) and pyribambenz-isopropyl (ZJ0702)
Both belonging to miazines herbicides, pyribambenz-propyl and pyribambenz-isopropyl which
could control annual grassy weeds and some broadleaf weeds in rape field were jointly
developed by ZCIRI and Shanghai Institute of Organic Chemistry, Chinese Academy of
Sciences. Although Shandong Qiaochang acquired temporary registrations of both two
herbicides in 2003, both have already expired.
Methiopyrsulfuron (HNPC-C9908)
Methiopyrsulfuron is a sulfonylurea herbicide developed by HRICI. HRICI was cooperating
with a company in methiopyrsulfuron commercialization. Hunan Haili registered 95%
methiopyrsulfuron technical (Reg.
No.:LS20060244) and methiopyrsulfuron 10% WP (Reg.
No.:LS20060229) in 2006, which both expired. The latter was registered for post-emergence
control of broad-leaf weeds and some grassy weeds in wheat fields. Methiopyrsulfuron got
patent in China in 2003 (Patent Number: ZL00113423.X).
Clacyfos (HW02)
Clacyfos, developed by the Central China Normal University in 2009 under the code name of
HW02, is a phosphonate ester of the phenoxyacetic herbicide. As a herbicide with
independent intellectual property rights, clacyfos owns a very good capacity in managing
annual broadleaf weeds and some monocotyledonous weeds in the field of corn, wheat and

5. lawn, orchard and tea garden, such as amaranthus retroflexus, acalypha and abutilon. The
mechanism of action of clacyfos is the inhibitor of pyruvate dehydrogenase. Shandong
Qiaochang secured the temporary registrations of clacyfos (93% technical and 30% EC) in
2007.
Table of Contents of China Crop Protection Monthly Report 1312
Registered Chinese herbs used as pesticides
Potential pesticide ingredients developed by China are to enter market in the future
Introduction to self-developed herbicides by China with valid registrations
18 self-developed pesticides without renewal of technical registrations
Introduction to self-developed insecticides by China with valid registrations
Introduction to self-developed fungicides by China with valid registrations
Pesticide innovation in China
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