Silicone Based Drug Delivery Systems

Silicone Based Drug Delivery Systems Dr. Basavaraj K. Nanjwade M.Pharm., Ph.D Associate Professor Department of Pharmaceutics KLE University BELGAUM -590010, Karnataka, INDIA E-mail: [email_address] Cell No: 00919448716277

Silicone in Drug Delivery Application Nano Technology DDS Buccal DDS Rectal DDS Vaginal DDS Pulmonary DDS Nasal DDS Topical DDS Parentral DDS Oral DDS Silicone

Silicone Polymers ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

Silicone systems Adhesives Elastomers Resins Gels Emulsifiers

Silicone Materials ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

Silicone Fluids ,[object Object],[object Object],[object Object]

Silicone Gels ,[object Object],[object Object],[object Object]

Silicone pressure sensitive adhesives ,[object Object],[object Object],[object Object]

Silicone Elastomers Silicone Elastomers High consistency Elastomers (rubber) Liquid silicone Rubber or LSR’s Low consistency elastomers Adhesive

High consistency elastomers ,[object Object],[object Object],[object Object]

Liquid silicone rubbers or LSR’s ,[object Object],[object Object],[object Object],[object Object]

Low consistency elastomers ,[object Object],[object Object],[object Object]

Adhesive ,[object Object],[object Object]

Difisivity ,[object Object],[object Object],[object Object]

Silicone for Drug Delivery Systems ,[object Object],[object Object],[object Object]

Adhesives for Transdermal Drug Delivery Systems ,[object Object],[object Object],[object Object]

Excipient and Film-Forming Materials for Topical Drug Delivery Systems ,[object Object],[object Object],[object Object]

Emulsions ,[object Object],[object Object],[object Object]

Emulsions ,[object Object],[object Object]

Gels ,[object Object],[object Object]

Benefits of Silicone Based Drug Delivery Systems ,[object Object],[object Object],[object Object],[object Object],[object Object]

Transporter/Receptor-Targeted Drug Delivery

Aesthetic Benefits of Silicone Excipients Sensory evaluation (paired comparison) of (a) an ointment containing petrolatum (70%), ST- Cyclomethicone 5-NF (15%) and ST-Elastomer 10 (15%) versus (b) petrolatum (100%)

Aesthetic Benefits of Silicone Excipients Sensory evaluation (paired comparison) of (a) the hydrogel with Dimethiconol Blend 20 (5%) and ST-Elastomer 10 (10%) versus (b) the same hydrogel with no silicone

Aesthetic Benefits of Silicone Excipients Sensory evaluation (paired comparison) of (a) water-in-oil based on mineral oil (2%), petrolatum (5%) and Silky Wax 10 (5%) versus (b) water-in-oil emulsion based on mineral oil (10%), ST-Cyclomethicone 5-NF (10%) and Dimethiconol Blend 20 (5%). The same silicone surfactant (2% of Emulsifier 10) has been used in both formulations

Pharmacokinetic Benefits of Silicone Excipients Substantivity of silicone gum on skin over the time. Formulation silicone gum (3%) and hexamethyldisiloxane (97%). Test done on the forearm of 5 panelists. The silicone remaining on the skin of the panelists is analyzed by ATR-FTIR spectroscopy

Pharmacokinetic Benefits of Silicone Excipients Substantivity of Ketoprofen on skin over time. Formulation (a) Ketoprofen (2.5%), Hexamethyldisiloxane (94.5%) and silicone gum (3%). Formulation (b) Ketoprofen (2.5%) and Hexamethyldisiloxane (97.5%). Test done on the forearm of 5 panelist. Semi-quantitative analysis of Ketoprofen remaining on the skin of the panelists done by ATR-FTIR spectroscopy

Pharmacokinetic Benefits of Silicone Excipients Comparison of the penetration rate of ibuprofen(5%) through hairless rat skin in static diffusion cells silicone-based formulations (silicone gum in hexamethyldisiloxane) versus a silicone free hydrogel

Pharmacokinetic Benefits of Silicone Excipients Comparison of the penetration rate of econazole nitrate (1%) through hairless rat skin static diffusion cells silicone-based formulations (silicone gum in hexamethyldisiloxane) versus a silicone-free emulsion

Pharmacokinetic Benefits of Silicone Excipients Comparison of penetration rate of hydrocortisone (5%) through hairless rat skin in static diffusion cells of silicone-based formulations (silicone gum in hexamethyldisiloxane) versus a silicone-free emulsion

Healthcare Applications ,[object Object]

Evaluation and Fabrication ,[object Object],[object Object]

Evaluation and Fabrication ,[object Object],[object Object],[object Object]

Enhanced permeability and retention effect (EPR effect )

Transferrin – mediated targeting

Drug Eluting applications Antidepressants Anxiolytics Vitamins, B6, D & E Antifungal Opioid analgesic Antiviral compounds

[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],Rate enhancing additives

Conclusion ,[object Object],[object Object],[object Object]

Conclusion Cont… ,[object Object],[object Object],[object Object]

Conclusion Cont… ,[object Object],[object Object]

Silicone Based Drug Delivery Systems

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Silicone Based Drug Delivery Systems