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- 1. Copyright Š 2004 Pearson Education, Inc., publishing as Benjamin Cummings PowerPointŽ Lecture Slide Presentation prepared by Christine L. Case Microbiology AN INTRODUCTION EIGHTH EDITION TORTORA ⢠FUNKE ⢠CASE Chapter 21, part B Microbial Diseases of the Skin and Eyes
- 2. Copyright Š 2004 Pearson Education, Inc., publishing as Benjamin Cummings ⢠Smallpox (Variola) ⢠Smallpox virus (Orthopox virus) ⢠Variola major has 20% mortality ⢠Variola minor has <1% mortality ⢠Monkeypox ⢠Prevention by smallpox vaccination Poxviruses Figure 21.9
- 3. Copyright Š 2004 Pearson Education, Inc., publishing as Benjamin Cummings ⢠Varicella-zoster virus (Human herpes virus 3) ⢠Transmitted by the respiratory route ⢠Causes pus-filled vesicles ⢠Virus may remain latent in dorsal root ganglia Herpesviruses Figure 21.10a
- 4. Copyright Š 2004 Pearson Education, Inc., publishing as Benjamin Cummings ⢠Reactivation of latent HHV-3 releases viruses that move along peripheral nerves to skin. Shingles Figure 21.10b
- 5. Copyright Š 2004 Pearson Education, Inc., publishing as Benjamin Cummings ⢠Human herpes virus 1 and HHV-2 ⢠Cold sores or fever blisters (vesicles on lips) ⢠Herpes gladiatorum (vesicles on skin) ⢠Herpes whitlow (vesicles on fingers) ⢠Herpes encephalitis (HHV-2 has up to a 70% fatality rate) ⢠HHV-1 can remain latent in trigeminal nerve ganglia ⢠HHV-2 can remain latent in sacral nerve ganglia ⢠Acyclovir may lessen symptoms Herpes simplex 1 and Herpes simplex 2
- 6. Copyright Š 2004 Pearson Education, Inc., publishing as Benjamin Cummings ⢠Measles virus ⢠Transmitted by respiratory route ⢠Macular rash and Koplik's spots ⢠Prevented by vaccination ⢠Encephalitis in 1 in 1000 cases ⢠Subacute sclerosing panencephalitis in 1 in 1,000,000 cases Measles (Rubeola) Figure 21.14
- 7. Copyright Š 2004 Pearson Education, Inc., publishing as Benjamin Cummings Measles (Rubeola) Figure 21.13
- 8. Copyright Š 2004 Pearson Education, Inc., publishing as Benjamin Cummings ⢠Rubella virus ⢠Macular rash and fever ⢠Congenital rubella syndrome causes severe fetal damage ⢠Prevented by vaccination Rubella (German Measles) Figure 21.15
- 9. Copyright Š 2004 Pearson Education, Inc., publishing as Benjamin Cummings ⢠A 1905 list of skin rashes included #1- measles, #2-scarlet fever, #3-rubella, #4- Filatow-Dukes (mild scarlet fever), and #5- ⢠Fifth Disease ⢠Human parvovirus B19 produces milk flu-like symptoms and facial rash ⢠Roseola ⢠Human herpesvirus 6 causes a high fever and rash, lasting for 1-2 days
- 10. Copyright Š 2004 Pearson Education, Inc., publishing as Benjamin Cummings ⢠Dermatomycoses: tineas or ringworm ⢠Metabolize keratin ⢠Trichophyton infects hair, skin, nails ⢠Epidermophyton infects skin and nails ⢠Microsporum infects hair and skin ⢠Treatment ⢠Oral griseofulvin ⢠Topical miconazole Cutaneous Mycoses
- 11. Copyright Š 2004 Pearson Education, Inc., publishing as Benjamin Cummings Cutaneous Mycoses Figure 21.16
- 12. Copyright Š 2004 Pearson Education, Inc., publishing as Benjamin Cummings ⢠Sporotrichosis ⢠Sporothrix schenckii enters puncture wound ⢠Treated with KI Subcutaneous Mycoses
- 13. Copyright Š 2004 Pearson Education, Inc., publishing as Benjamin Cummings ⢠Candida albicans (yeast) ⢠Candidiasis may result from suppression of competing bacteria by antibiotics ⢠Occurs in skin; mucous membranes of genitourinary tract and mouth ⢠Thrush is an infection of mucous membranes of mouth ⢠Topical treatment with miconazole or nystatin Candidiasis
- 14. Copyright Š 2004 Pearson Education, Inc., publishing as Benjamin Cummings Candidiasis Figure 21.17
- 15. Copyright Š 2004 Pearson Education, Inc., publishing as Benjamin Cummings ⢠Sarcoptes scabiei burrows in the skin to lay eggs ⢠Treatment with topical insecticides Scabies Figure 21.18
- 16. Copyright Š 2004 Pearson Education, Inc., publishing as Benjamin Cummings ⢠Pediculus humanus capitis (head louse) ⢠P. h. corporis (body louse) ⢠Feed on blood ⢠Lay eggs (nits) on hair ⢠Treatment with topical insecticides Pediculosis Figure 21.19
- 17. Copyright Š 2004 Pearson Education, Inc., publishing as Benjamin Cummings ⢠Conjunctivitis (pinkeye) ⢠Haemophilus influenzae ⢠Various microbes ⢠Associated with unsanitary contact lenses ⢠Neonatal gonorrheal ophthalmia ⢠Neisseria gonorrhoeae ⢠Transmitted to newborn's eyes during passage through the birth canal ⢠Prevented by treatment newborn's eyes with antibiotics Microbial Diseases of the Eye
- 18. Copyright Š 2004 Pearson Education, Inc., publishing as Benjamin Cummings ⢠Chlamydia trachomatis ⢠Inclusion conjunctivitis ⢠Transmitted to newborn's eyes during passage through the birth canal ⢠Spread through swimming pool water ⢠Treated with tetracycline ⢠Trachoma ⢠Greatest cause of blindness worldwide ⢠Infection causes permanent scarring; scars abrade the cornea leading to blindness Microbial Diseases of the Eye
- 19. Copyright Š 2004 Pearson Education, Inc., publishing as Benjamin Cummings Microbial Diseases of the Eye Figure 21.20
- 20. Copyright Š 2004 Pearson Education, Inc., publishing as Benjamin Cummings ⢠Herpetic Keratitis ⢠Herpes simplex virus 1 (HHV-1) ⢠Infects cornea, may cause blindness ⢠Treated with trifluridine ⢠Acanthamoeba keratitis ⢠Transmitted from water ⢠Associated with unsanitary contact lenses Microbial Diseases of the Eye
- 21. Copyright Š 2004 Pearson Education, Inc., publishing as Benjamin Cummings Microbial Diseases of the Eye Figure 21.21