Some of out products are: MigraCalm, MigraTest and MigraSIN

1. June 2011 INNOVATING in BIOFUNCTIONALISM

2.  About New Migrasin ®  Other Products

4. MIGRATEST® is a test kit to measure in vitro the level of DAO enzyme activity in blood. A low level of DAO hinders the adequate metabolism of histamine. The excessive accumulation of histamine can trigger migraine.  Other Products Migratest ® - Diagnosis

5. MIGRACALM® is a biofunctional device that applies controlled pressure on the point in the temples where most of the pain is focused, producing a sensation of relief without adverse effects.  Other Products Migracalm ® - Palliative device

6. 1.- Déficit de DAO como posible desencadenante de migraña. Estudio Migradao. Mayo de 2010, Jornada Internacional de Sensibilización sobre la Migraña. Congreso de los Diputados de España 1.C. Vidal, Catedrática de Nutrición y Bromatología de la Universidad de Barcelona, 2.F. Titus, Miembro de Honor de la Sociedad Española de Neurología, 3. Asociación Española de Pacientes con Cefalea (AEPAC), 4.- Dpt. Epidemiología del Colegio de Farmacéuticos de Barcelona. 2.- Supplementation of enteric coated Diamine Oxidase improves intestinal degradation of food-born biogenic amines in case of histamine intolerance. 2010 - March, 6th Annual Conference of the ENA in Vienna. A. Missbichler1, I. Mayer1, C. Pongracz2, F. Gabor3 and P. Komericki 1 Sciotec Diagnostic Technologies, Tulln, Austria. 2 Dept. of Nutritional Sciences, University of Vienna, Austria 3 Dept. of Pharmaceutical echnology & Biopharmaceutics, University of Vienna, Austria 4 Dept. of environmental Dermatology, Medical University of Graz, Austria. 3.- Histamine and histamine intolerance. 2007 - The American Journal of Clinical Nutrition Laura Maintz 1 and Natalija Novak 1, 1 Department of Dermatology and Allergology, University of Bonn, Germany. 4.- Effects of histamine and diamine oxidase activities on pregnancy: a critical review. 2008 - May 22, European Society of Human Reproduction and Embryology. Laura Maintz 1 , Verena Schwarzer 2 , Thomas Bieber 1 , Katrin van der Ven 2 and Natalija Novak , 1 Department of Dermatology and Allergology, University of Bonn, Germany., 2 Department of Obstetrics and Gynaecology, University of Bonn, Germany 5.- Evidence for a reduced histamine degradation capacity in a subgroup of patients with atopic eczema. 2005 - November 29, The Journal of Allergy and Clinical Immunology Laura Maintz, MD a - Said Benfadal a , Jean-Pierre Allam, MD a – Tobias Hagemann, MD a – Rolf Fimmers, PhD b and Natalija Novak, MD a Bonn, Germany. a The Department of Dermatology, University of Bonn. b The Department of Medical Biometry, Informatics and Epidemiology, University of Bonn. 6.- Histamine intolerance: a metabolic disease? 2009 - December 12, Birkhäuser Verlag, Basel/Switzerland 2009 H.G. Schwelberger, 1 Molecular Biology Laboratory, Department of Visceral, Transplant and Thoracic Surgery, Medical University Innsbruck, Austria. Scientific background

7. 7.- Effectiveness of a prolonged compression of scalp arteries on migraine attacks. June 2006 - Journal of Neurology. Volume 253, number 6 Prof. Carlo Cianchetti & Prof. Jousef Hmaidan. University dpt. Neurosciencies- Cagliari (Italy) 8.- Compression of Superficial Temporal Arteries by a Handmade Device: A Simple Way to Block or attenuate Migraine Attacks in Children and Adolescents. June 2009 – Journal Child Neurology, Volume 25, pp 67-70. Prof. Giussepina Ledda. University dpt. Neuroseciencies – Cagriari (Italy) 9.- Treatment of migraine attacks by compression of temporal superficial arteries using a device. April 2009 -Journal of Neurology. Medical Science Monitor – New York CR 185-8 Prof. Carlo Cianchetti, Prof. Tiziana Pisano, Prof. Elisabeth Cianchetti & Prof. Giussepina Ledda University dpt. Neurosciencies – Cagliari (Italy) 10.-Legal-medical and neurological assessment of its informative distribution as a medical device used to relieve migraines. May 2008 - Autonomous University of Barcelona-Valle Hebron University Hospital. Ref. 18/08 Prof. Manuel Rodriguez Pazos & Prof. Manuel Romacho Romero. Schhol of Medicine. Autonomous University of Barcelona University Hospital Valle Hebrón. Scientific background (2)

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