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Investor Presentation
           April 2012
SAFE HARBOR


  Certain statements in this release concerning our future growth prospects are forward-
  looking statements, which are subject to a number of risks, uncertainties and
  assumptions that could cause actual results to differ materially from those contemplated
  in such forward-looking statements. Important factors that could cause actual results to
  differ materially from our expectations include, amongst others general economic and
  business conditions in India, our ability to successfully implement our strategy, our
  research and development efforts, our growth and expansion plans and technological
  changes, changes in the value of the Rupee and other currency changes, changes in the
  Indian and international interest rates, change in laws and regulations that apply to the
  Indian and global biotechnology and pharmaceuticals industries, increasing competition
  in and the conditions of the Indian biotechnology and pharmaceuticals industries,
  changes in political conditions in India and changes in the foreign exchange control
  regulations in India. Neither our company, nor our directors, nor any of their respective
  affiliates have any obligation to update or otherwise revise any statements reflecting
  circumstances arising after this date or to reflect the occurrence of underlying events,
  even if the underlying assumptions do not come to fruition.




                                                                                              2
AGENDA



     SNAPSHOT


     PORTFOLIO SPREAD


     STRATEGIC ALLIANCES


     RESEARCH & DEVELOPMENT


     FINANCIAL HIGHLIGHTS



                              3
SNAPSHOT
INTRODUCTION


       Biocon is an emerging, global Bio-pharmaceutical enterprise,
    focused on innovation to develop affordable products and services
      for patients, partners and healthcare systems across the world.


 Biocon is committed towards:

         Reducing therapy costs of chronic diseases. (diabetes, cancer & auto-immune diseases)



                   Strategic Research and marketing partnerships that provide global access



         Leveraging the India advantage to deliver high value, licensable R&D assets




                                                                                                 5
FY12 HIGHLIGHTS


      Financial Performance

      • Group Revenue at Rs. 2,148 Crores (16% YoY growth)
      • EBITDA at Rs. 579 Crores (EBITDA Margin: 27% )


      Research & Development

       • Itolizumab 52-week study successfully meets primary & secondary endpoints
       • Global phase I for phybrid initiated (Amylin partnership)
       • Phase III trials for emerging markets commenced for Biosimilar Trastuzumab
         (Herceptin, Mylan alliance); Phase I for developed markets ongoing.
       • Global biosimilar Insulin trials nearing completion


      Strategic Alliances

      • 20+ new partnerships initiated in Syngene, including big pharma
      • Amicable conclusion of biosimilar Insulin partnership with Pfizer
                                                                                      6
BUSINESS STRUCTURE & HOLDINGS

                                                         BIOPHARMA SUBSIDIARIES
                                                      Biocon Research , India | 100%
                                                      R&D- Novel Molecules

                                                      Biocon Biopharmaceuticals | 100%
                                                      MAbs and Biosimilars

                                                      Biocon Sdn. Bhd, Malaysia | 100%
                                                      Overseas subsidiary
 ~61% | Promoters
                                                      Biocon SA, Switzerland | 100%
                                                      Overseas subsidiary
 ~ 8 % | Employees & ESOP trust   Biocon              NeoBiocon, UAE | 50%
                                                                                             PRODUCTS

 ~31 % | Public                                       Overseas subsidiary



                                                              RESEARCH SERVICES

                                                     Syngene International, India | 100%
                                                     Custom research, drug discovery
                                                     Clinigene International, India | 100%   RESEARCH
                                                     Clinical development
                                                                                             SERVICES


             Spanning the entire Value Chain with capabilities ranging from
                              discovery to manufacturing                                          7
MANAGING THE FUTURE

                                                            ANDAs & 505b2 filings


                                               Small
                                              Molecules


                                                                                    Newer markets;
Integrated                                                                           Progressing to
offerings from             Research                               Biosimilars
                                                                                           Devices
discovery to clinics       Services                              (Biologics &
                                              Growth               Insulins)
                                              Verticals




                 Greater          Novel                     Branded             Rapidly growing,
                                 Molecules                Formulations     India-centric business
             risk-reward
               paradigm


                                      EMERGING MARKETS FOCUS
                                        EMERGING MARKETS FOCUS                                        8
PORTFOLIO SPREAD
DIVERSIFIED OFFERINGS

             Small Molecules: Base Business                                     Moving up the Value Chain




                         Insulins &
                                                 Other             Branded              Research            Biosimilars
  Statins                 Immuno
                                                                 Formulations
                        Suppressants          Biopharma                                 Services              & Novels




 Portfolio                     Constituents

 Statins                       Simvastatin, Atorvastatin, Lovastatin, Rosuvastatin, Fluvastatin & Pravastatin

 Insulins &                    Insulin and analogs
 Immuno suppressants           Tacrolimus, MMF & MPA
 Other Biopharma               Orlistat, Fidaxomicin, 50+ other molecules

 Branded Formulations          Diabetology, Cardiology, Nephrology, Oncology, Immunotherapy, Comprehensive Care

 Research Services             Syngene (Custom Research)
                               Clinigene (Clinical research)
 Biosimilar Biologics          Insulin & Analogs; Biosimilar MAbs

 Novel Molecules               IN-105, Itolizumab and others                                                              10
INSULINS: GLOBAL OPPORTUNITY (1)


                         Total 2011 Insulin Market: USD ~17 Bn
                                                                                                                            USD
                                                                                                                   13%     ~17 Bn
                 rh insulin                                                                               23%
                    20%
                                                                                                 17%
                                    lispro
                                     14%                                              43%


    glargine                         detemir                     USD
      32%                              9%                                    4%
                                                                ~15 Bn

                                               glulisine
                                                  2%
                          aspart
                           23%
                                                                  2010    rh Insulin Glargine   Lispro   Aspart   Others     2011

          Market Breakup by Molecule                                            Growth Contribution by Molecule




Source: Estimates compiled from earnings release of respective companies & IMS data                                           11
INSULINS: GLOBAL OPPORTUNITY (2)

              2011 Landscape                                        The shift underway
                                   3%
                                               1%
          17%                      7%                   Total Diabetic Population 2011: 366 Mn
                                                            Developed Markets: 80 Mn
                                   7%
                                                            Emerging markets: 286 Mn
          9%
                                                        Diabetes Population 2030E: 552 Mn
                                  24%                       Developed Markets: 96 Mn
                                                            Emerging markets: 456 Mn

                                                        Diabetes prevalence expected to go up
          52%                                            from current levels of 8% to 10% in 2030

                                                        Diabetes prevalence expected to rapidly increase
                                                         in Africa, MENA and Urban Areas of BRIC-TM
                                  57%
                                                        More than half of the current diabetic population
          5%
                                                         in emerging markets remains undiagnosed with
          10%                                            limited access to affordable healthcare

          7%

   Diabetic Population        Insulin Market
    North America    Europe          Japan & Oceania
    BRIC-TM          MENA            RoW
                                                       Source: International Diabetes Atlas 2011         12
BIOSIMILAR INSULINS PORTFOLIO


           Committed to delivering affordable, quality insulin
                          to global markets

  • rh-Insulin             • 30+ registrations in       • rh-Insulin:
                             Emerging markets             • Phase 3 trial in EU
                                                          • Commercialized in several
  • Basal insulin analog                                    geographies including India
                           • Strong regional partners   • Glargine
  • Rapid acting insulin     in major markets             • Active US-IND
    analogs                  including Japan & China      • Global Phase 1 trial ongoing
                                                          • Commercialized in India

                            Regional                    Molecule
   Portfolio
                            Partnerships                Status




                                                                                           13
BRANDED FORMULATIONS : THERAPEUTIC SEGMENTS




                                              14
BRANDED FORMULATIONS : CARVING A NICHE

                Affordability Index*                        INDIA PRODUCT RANKINGS#
                                                   Cardiology
              Basalog: 40%
                                                                           Myokinase    2
              Insugen: 15%
                                                                              Clotide   2
               Bestor: 30%                         Oncotherapeutics
                                                                        BioMAb EGFR     2
               Statix: 25%
                                                                            Abraxane    3
              Advacan: 45%                         Immunotherapy
              Tacrograf: 30%                                                   Psorid   1
                                                                                 Tbis   2
               Evertor: 59%
                                                                                Picon   2
               BioMAb EGFR: 53%
                                                   Nephrology
              Picon: 37%                                                    Tacrograf   2
              Psorid: 26%                                       Renodapt & Renodapt S   3


*: Compared to the top selling competitor brand;
#: ORG IMS Jan MAT 2012
                                                                                            15
BRANDED FORMULATIONS: #1 Indian Insulin Company


            Biocon’s Volume           Value Growth YoY*                  Biocon’s ranking*
             Market share*
                                   Fastest growing Insulin company
                                                                     #4 in overall insulin market
    40 IU Insulin: 11%             Biocon: 53%
                                   Sanofi Aventis: 29%               #3 in the 40 IU Insulin market
    Glargine vials: 84%
                                   Novo Nordisk: 25%                 #1 in the Glargine vial market


  INSUPen® ease

  Reusable delivery device based
  on proprietary German
  technology, capable of
  delivering both InsugenTM &
  BasalogTM launched in India



 * : ORG IMS MAT Feb 2012
                                                                                                      16
RESEARCH SERVICES: From Labs to Clinics




                                          17
RESEARCH SERVICES: VALUE-BASED POSITIONING


      Integrated Model spanning discovery & early
        development to late stage clinical studies
                                                              Component
                                                                 Play


   Large Portfolio of Offerings combining Chemistry &
         Biologics expertise with cost advantage        Cluster Play




   Custom partnership models ranging from FTE based            Integrated
                to risk-reward models


                                                        Incubative
     Clientele comprising of 100+ large and mid-size
              pharma & biotech companies
                                                                            18
STRATEGIC ALLIANCES
STRATEGIC PARTNERSHIPS


                       Amylin         Diabetes            Peptide Hybrid
                       CIMAb          Oncology        BioMAb EGFR, Itolizumab
       Discovery
                       IATRICa        Oncology        Immuno-conjugated MAbs
                       Vaccinex       Oncology            Biobetter MAbs


                                    First in Class
                       Optimer                              Fidaxomicin
                                    Anti Infective
   Commercialization
                                     Oncology &
                        Mylan                               Biosimilars
                                    Auto Immune


                                    Discovery to
   Research Services    BMS                            Integrated DD Services
                                  Commercialization




                                                                                20
BIOSIMILARS COMMERCIALIZATION PARTNERSHIP: MYLAN

Monoclonal Antibodies (MAbs)
                            Combines Biocon's R&D and manufacturing prowess of
                            biologics with Mylan’s regulatory & commercialization
                                       capabilities in the US and Europe

                Market Value of Portfolio in 2011: ~33 Bn USD
                    Exclusive collaboration for development and commercialization of
                                                   .
                                          complex biosimilars.
                       Basket of Products with patent expiries 2015 onward
               (Trastuzumab, Peg-filgrastim, Bevacizumab, Adalimumab, Eternacept)

                     Mylan and Biocon to share development and capital costs.

             Mylan will have exclusive commercialization rights in the regulated markets;
                                         profits to be shared

            Biocon and Mylan to have co-exclusive commercialization rights in other markets.

                                                                                               21
FIDAXOMICIN PARTNERSHIP: OPTIMER

First-in-class Anti-Infective
                          Combines Biocon's R&D and manufacturing prowess of
                               novel biologics with Optimer’s proprietary
                                          molecule technology


                        Exclusive collaboration for manufacture & supply of
                        Fidaxomicin API for DIFICIDTM & DIFICLIRTM tablets
                                               .


                 Extension of prior relationship where Biocon assisted Optimer
                                  with product development

                           Launched in US; Approval received for EU




                                                                                 22
Research & Development
RESEARCH PARTNERSHIPS : HIGH POTENTIAL PRODUCT PIPELINE

 Product             Therapeutic Area      Drug               Partner         Discovery     Preclinical Phase I     Phase II     Phase III       Market


                     Diabetes           IN 105

                     Oncology /
                                        Itolizumab            CIMAb                                                                          #
  Novel Molecules*




                     Inflammation /
                     Auto immune

                     Oncology           Nimotuzumab           CIMAb


                     Oncology           Anti-CD 20            Vaccinex


                     Oncology           Fusion Proteins       IATRICa


                     Diabetes           Peptide Hybrid        Amylin


                     Oncology/
  Biosimilars*




                                                                                  Other MAbs &       Biosimilar
                                        Biosimilar MAbs       Mylan                 PEG- GCSF       Trastuzumab
                     Immunology

                     Diabetes           Insulin & Analogues                        Lispro, Aspart                 rH Insulin, Glargine


                     Oncology             Others                                                                  GCSF, EPO


  * Includes molecules from collaborative programs;                      # Phase 3 TREAT PLAQ study In India, Phase 2(b) globally                         24
ANTI- CD6 MAB: ITOLIZUMAB

Drug Highlights

     Targets CD6
    CD6 is a type 1 cell membrane glycoprotein belonging to the scavenger receptor cysteine-rich
    (SRCR) super family group B.
   CD6 is predominantly expressed by T cells & a B cell subset.
   CD6 binds ALCAM (activated leukocyte cell adhesion molecule) which is expressed on:
           Activated T, cells, B cells & monocytes.
           Skin fibroblasts, keratinocytes, rheumatoid arthritis synovium.


 TREAT-PLAQ Study in Psoriasis

                                    Total Patient Enrollment                                223
                                             Trial Duration                            52 Weeks
                                    Interim Data Presented*                            28 Weeks


 * 52- week clinical study report and the regulatory submission package is currently being prepared for submission to the authorities.
 Key data would be shared in concurrence with the submission.                                                                            25
TREAT PLAQ STUDY: SUMMARY OF 28-WEEK INTERIM RESULTS

                52-Week data confirms achievement of primary and secondary end-points

  PRIMARY ENDPOINT                                                                    Result*
  Statistically significant patient cohort with ≥ PASI 75 Vs. placebo at 12 Weeks        

  SECONDARY ENDPOINTS
  Significant Proportion of subjects achieving PASI 50 and PASI 90                       
  Safety & Tolerability                                                                  
  Improvement in PGA scores                                                              
  Considerable Proportion of subjects with PGA score of “clear” or “minimal”             

 PASI: Psoriasis Area Severity Index   PGA: Physicians Global Assessment            *p <0.05   26
TREAT PLAQ STUDY : EFFICACY RESULTS
 Representative patient samples from each arm.
            Week        Baseline                 12 Weeks   28 Weeks

     Trial Arm


    Induction
    Dose Arm




   Fixed Dose
          Arm




  Placebo Arm



                                                                       27
ORAL INSULIN : IN 105


   Hepatic portal-vein-delivery                                            Adequate post-prandial
                                                                               glucose control
   Prime liver effect and
     benefit of “hepatic                                                    Reduces the risk of
     buffering”                                                                hypoglycaemia
   No sustained peripheral                                                 Weight neutral
     hyper-insulinemia
                                                                            Action independent of
   Emulates innate                                                            pancreas functionality
     insulin physiology




                                   Potential Therapeutic Use
              Potential use across the diabetic treatment continuum
                       Concomitant use with OADs or monotherapy
                       “Bridge therapy” to intensive insulin therapy
                       Post-prandial control component with basal insulin therapy                  28
IN-105 INDIA PHASE III RESULT SUMMARY

        IN-105 shows clear efficacy as a prandial insulin in lowering post-prandial glucose levels




       SECONDARY END POINTS
   Efficacy – Secondary Endpoints
         Statistically significant reduction in PPG during STM                                 
         Significant reduction in SMBG post prandial glucose excursion                         
   Safety – Secondary Endpoints
        No clinically significant hypoglycemia                                                 
         Very low immunogenicity                                                               
         No neutralizing antibodies detected                                                   
         No effect on liver enzymes                                                            
         No effect on lipid profiles                                                           
         No effect on renal function                                                           
  Efficacy – Primary Endpoint
     Change in Hb1Ac for IN-105 not statistically significant due to higher than anticipated
     placebo effect
                                                                                               X     29
FINANCIAL HIGHLIGHTS
TOP LINE# & BOTTOM LINE#
                                                                                                                   INR crore / USD mn

                                                 FY08                FY09            FY10               FY11
    Revenue                              1,090 273 1,194 260                      1,493       318      1,858 407
    EBITDA                                335   83   372 81                         455        97        573 125
    Net profit*                           225   56   238 52                         273        58        340 74


                                                      FY12                    FY11
                               Revenue           2,148 | 445             1,858 | 407
                               EBIDTA              579 | 120               573 | 125
                                                              27%                    31%
                               PAT                  338 | 70               340 | 74
                                                              16%                    19%
                               EPS                    17.3                    17.4

    FY08-11: Avg.exch.rate in that fiscal ; FY12: USD 1 = INR 48.1; FY11: USD 1= INR 45.67
    # 78% stake acquired in Axicorp GmBH in April ‘08.; fully divested as of March’11 . Hence all figures are ex-Axicorp.
    Figures for FY11 and FY12 in accordance with latest revisions in schedule VI.
    * Net profit is pre-exceptional in table 1.No exceptional items in FY10 and FY11.                                             31
Thank You

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Biocon Q4FY12_Investor Presentation_April_2012

  • 2. SAFE HARBOR Certain statements in this release concerning our future growth prospects are forward- looking statements, which are subject to a number of risks, uncertainties and assumptions that could cause actual results to differ materially from those contemplated in such forward-looking statements. Important factors that could cause actual results to differ materially from our expectations include, amongst others general economic and business conditions in India, our ability to successfully implement our strategy, our research and development efforts, our growth and expansion plans and technological changes, changes in the value of the Rupee and other currency changes, changes in the Indian and international interest rates, change in laws and regulations that apply to the Indian and global biotechnology and pharmaceuticals industries, increasing competition in and the conditions of the Indian biotechnology and pharmaceuticals industries, changes in political conditions in India and changes in the foreign exchange control regulations in India. Neither our company, nor our directors, nor any of their respective affiliates have any obligation to update or otherwise revise any statements reflecting circumstances arising after this date or to reflect the occurrence of underlying events, even if the underlying assumptions do not come to fruition. 2
  • 3. AGENDA SNAPSHOT PORTFOLIO SPREAD STRATEGIC ALLIANCES RESEARCH & DEVELOPMENT FINANCIAL HIGHLIGHTS 3
  • 5. INTRODUCTION Biocon is an emerging, global Bio-pharmaceutical enterprise, focused on innovation to develop affordable products and services for patients, partners and healthcare systems across the world. Biocon is committed towards: Reducing therapy costs of chronic diseases. (diabetes, cancer & auto-immune diseases) Strategic Research and marketing partnerships that provide global access Leveraging the India advantage to deliver high value, licensable R&D assets 5
  • 6. FY12 HIGHLIGHTS Financial Performance • Group Revenue at Rs. 2,148 Crores (16% YoY growth) • EBITDA at Rs. 579 Crores (EBITDA Margin: 27% ) Research & Development • Itolizumab 52-week study successfully meets primary & secondary endpoints • Global phase I for phybrid initiated (Amylin partnership) • Phase III trials for emerging markets commenced for Biosimilar Trastuzumab (Herceptin, Mylan alliance); Phase I for developed markets ongoing. • Global biosimilar Insulin trials nearing completion Strategic Alliances • 20+ new partnerships initiated in Syngene, including big pharma • Amicable conclusion of biosimilar Insulin partnership with Pfizer 6
  • 7. BUSINESS STRUCTURE & HOLDINGS BIOPHARMA SUBSIDIARIES Biocon Research , India | 100% R&D- Novel Molecules Biocon Biopharmaceuticals | 100% MAbs and Biosimilars Biocon Sdn. Bhd, Malaysia | 100% Overseas subsidiary ~61% | Promoters Biocon SA, Switzerland | 100% Overseas subsidiary ~ 8 % | Employees & ESOP trust Biocon NeoBiocon, UAE | 50% PRODUCTS ~31 % | Public Overseas subsidiary RESEARCH SERVICES Syngene International, India | 100% Custom research, drug discovery Clinigene International, India | 100% RESEARCH Clinical development SERVICES Spanning the entire Value Chain with capabilities ranging from discovery to manufacturing 7
  • 8. MANAGING THE FUTURE ANDAs & 505b2 filings Small Molecules Newer markets; Integrated Progressing to offerings from Research Biosimilars Devices discovery to clinics Services (Biologics & Growth Insulins) Verticals Greater Novel Branded Rapidly growing, Molecules Formulations India-centric business risk-reward paradigm EMERGING MARKETS FOCUS EMERGING MARKETS FOCUS 8
  • 10. DIVERSIFIED OFFERINGS Small Molecules: Base Business Moving up the Value Chain Insulins & Other Branded Research Biosimilars Statins Immuno Formulations Suppressants Biopharma Services & Novels Portfolio Constituents Statins Simvastatin, Atorvastatin, Lovastatin, Rosuvastatin, Fluvastatin & Pravastatin Insulins & Insulin and analogs Immuno suppressants Tacrolimus, MMF & MPA Other Biopharma Orlistat, Fidaxomicin, 50+ other molecules Branded Formulations Diabetology, Cardiology, Nephrology, Oncology, Immunotherapy, Comprehensive Care Research Services Syngene (Custom Research) Clinigene (Clinical research) Biosimilar Biologics Insulin & Analogs; Biosimilar MAbs Novel Molecules IN-105, Itolizumab and others 10
  • 11. INSULINS: GLOBAL OPPORTUNITY (1) Total 2011 Insulin Market: USD ~17 Bn USD 13% ~17 Bn rh insulin 23% 20% 17% lispro 14% 43% glargine detemir USD 32% 9% 4% ~15 Bn glulisine 2% aspart 23% 2010 rh Insulin Glargine Lispro Aspart Others 2011 Market Breakup by Molecule Growth Contribution by Molecule Source: Estimates compiled from earnings release of respective companies & IMS data 11
  • 12. INSULINS: GLOBAL OPPORTUNITY (2) 2011 Landscape The shift underway 3% 1% 17% 7%  Total Diabetic Population 2011: 366 Mn  Developed Markets: 80 Mn 7%  Emerging markets: 286 Mn 9%  Diabetes Population 2030E: 552 Mn 24%  Developed Markets: 96 Mn  Emerging markets: 456 Mn  Diabetes prevalence expected to go up 52% from current levels of 8% to 10% in 2030  Diabetes prevalence expected to rapidly increase in Africa, MENA and Urban Areas of BRIC-TM 57%  More than half of the current diabetic population 5% in emerging markets remains undiagnosed with 10% limited access to affordable healthcare 7% Diabetic Population Insulin Market North America Europe Japan & Oceania BRIC-TM MENA RoW Source: International Diabetes Atlas 2011 12
  • 13. BIOSIMILAR INSULINS PORTFOLIO Committed to delivering affordable, quality insulin to global markets • rh-Insulin • 30+ registrations in • rh-Insulin: Emerging markets • Phase 3 trial in EU • Commercialized in several • Basal insulin analog geographies including India • Strong regional partners • Glargine • Rapid acting insulin in major markets • Active US-IND analogs including Japan & China • Global Phase 1 trial ongoing • Commercialized in India Regional Molecule Portfolio Partnerships Status 13
  • 14. BRANDED FORMULATIONS : THERAPEUTIC SEGMENTS 14
  • 15. BRANDED FORMULATIONS : CARVING A NICHE Affordability Index* INDIA PRODUCT RANKINGS# Cardiology Basalog: 40% Myokinase 2 Insugen: 15% Clotide 2 Bestor: 30% Oncotherapeutics BioMAb EGFR 2 Statix: 25% Abraxane 3 Advacan: 45% Immunotherapy Tacrograf: 30% Psorid 1 Tbis 2 Evertor: 59% Picon 2 BioMAb EGFR: 53% Nephrology Picon: 37% Tacrograf 2 Psorid: 26% Renodapt & Renodapt S 3 *: Compared to the top selling competitor brand; #: ORG IMS Jan MAT 2012 15
  • 16. BRANDED FORMULATIONS: #1 Indian Insulin Company Biocon’s Volume Value Growth YoY* Biocon’s ranking* Market share* Fastest growing Insulin company #4 in overall insulin market 40 IU Insulin: 11% Biocon: 53% Sanofi Aventis: 29% #3 in the 40 IU Insulin market Glargine vials: 84% Novo Nordisk: 25% #1 in the Glargine vial market INSUPen® ease Reusable delivery device based on proprietary German technology, capable of delivering both InsugenTM & BasalogTM launched in India * : ORG IMS MAT Feb 2012 16
  • 17. RESEARCH SERVICES: From Labs to Clinics 17
  • 18. RESEARCH SERVICES: VALUE-BASED POSITIONING Integrated Model spanning discovery & early development to late stage clinical studies Component Play Large Portfolio of Offerings combining Chemistry & Biologics expertise with cost advantage Cluster Play Custom partnership models ranging from FTE based Integrated to risk-reward models Incubative Clientele comprising of 100+ large and mid-size pharma & biotech companies 18
  • 20. STRATEGIC PARTNERSHIPS Amylin Diabetes Peptide Hybrid CIMAb Oncology BioMAb EGFR, Itolizumab Discovery IATRICa Oncology Immuno-conjugated MAbs Vaccinex Oncology Biobetter MAbs First in Class Optimer Fidaxomicin Anti Infective Commercialization Oncology & Mylan Biosimilars Auto Immune Discovery to Research Services BMS Integrated DD Services Commercialization 20
  • 21. BIOSIMILARS COMMERCIALIZATION PARTNERSHIP: MYLAN Monoclonal Antibodies (MAbs) Combines Biocon's R&D and manufacturing prowess of biologics with Mylan’s regulatory & commercialization capabilities in the US and Europe Market Value of Portfolio in 2011: ~33 Bn USD Exclusive collaboration for development and commercialization of . complex biosimilars. Basket of Products with patent expiries 2015 onward (Trastuzumab, Peg-filgrastim, Bevacizumab, Adalimumab, Eternacept) Mylan and Biocon to share development and capital costs. Mylan will have exclusive commercialization rights in the regulated markets; profits to be shared Biocon and Mylan to have co-exclusive commercialization rights in other markets. 21
  • 22. FIDAXOMICIN PARTNERSHIP: OPTIMER First-in-class Anti-Infective Combines Biocon's R&D and manufacturing prowess of novel biologics with Optimer’s proprietary molecule technology Exclusive collaboration for manufacture & supply of Fidaxomicin API for DIFICIDTM & DIFICLIRTM tablets . Extension of prior relationship where Biocon assisted Optimer with product development Launched in US; Approval received for EU 22
  • 24. RESEARCH PARTNERSHIPS : HIGH POTENTIAL PRODUCT PIPELINE Product Therapeutic Area Drug Partner Discovery Preclinical Phase I Phase II Phase III Market Diabetes IN 105 Oncology / Itolizumab CIMAb # Novel Molecules* Inflammation / Auto immune Oncology Nimotuzumab CIMAb Oncology Anti-CD 20 Vaccinex Oncology Fusion Proteins IATRICa Diabetes Peptide Hybrid Amylin Oncology/ Biosimilars* Other MAbs & Biosimilar Biosimilar MAbs Mylan PEG- GCSF Trastuzumab Immunology Diabetes Insulin & Analogues Lispro, Aspart rH Insulin, Glargine Oncology Others GCSF, EPO * Includes molecules from collaborative programs; # Phase 3 TREAT PLAQ study In India, Phase 2(b) globally 24
  • 25. ANTI- CD6 MAB: ITOLIZUMAB Drug Highlights Targets CD6 CD6 is a type 1 cell membrane glycoprotein belonging to the scavenger receptor cysteine-rich (SRCR) super family group B. CD6 is predominantly expressed by T cells & a B cell subset. CD6 binds ALCAM (activated leukocyte cell adhesion molecule) which is expressed on: Activated T, cells, B cells & monocytes. Skin fibroblasts, keratinocytes, rheumatoid arthritis synovium. TREAT-PLAQ Study in Psoriasis Total Patient Enrollment 223 Trial Duration 52 Weeks Interim Data Presented* 28 Weeks * 52- week clinical study report and the regulatory submission package is currently being prepared for submission to the authorities. Key data would be shared in concurrence with the submission. 25
  • 26. TREAT PLAQ STUDY: SUMMARY OF 28-WEEK INTERIM RESULTS 52-Week data confirms achievement of primary and secondary end-points PRIMARY ENDPOINT Result* Statistically significant patient cohort with ≥ PASI 75 Vs. placebo at 12 Weeks  SECONDARY ENDPOINTS Significant Proportion of subjects achieving PASI 50 and PASI 90  Safety & Tolerability  Improvement in PGA scores  Considerable Proportion of subjects with PGA score of “clear” or “minimal”  PASI: Psoriasis Area Severity Index PGA: Physicians Global Assessment *p <0.05 26
  • 27. TREAT PLAQ STUDY : EFFICACY RESULTS Representative patient samples from each arm. Week Baseline 12 Weeks 28 Weeks Trial Arm Induction Dose Arm Fixed Dose Arm Placebo Arm 27
  • 28. ORAL INSULIN : IN 105  Hepatic portal-vein-delivery  Adequate post-prandial glucose control  Prime liver effect and benefit of “hepatic  Reduces the risk of buffering” hypoglycaemia  No sustained peripheral  Weight neutral hyper-insulinemia  Action independent of  Emulates innate pancreas functionality insulin physiology Potential Therapeutic Use  Potential use across the diabetic treatment continuum  Concomitant use with OADs or monotherapy  “Bridge therapy” to intensive insulin therapy  Post-prandial control component with basal insulin therapy 28
  • 29. IN-105 INDIA PHASE III RESULT SUMMARY IN-105 shows clear efficacy as a prandial insulin in lowering post-prandial glucose levels SECONDARY END POINTS Efficacy – Secondary Endpoints Statistically significant reduction in PPG during STM  Significant reduction in SMBG post prandial glucose excursion  Safety – Secondary Endpoints No clinically significant hypoglycemia  Very low immunogenicity  No neutralizing antibodies detected  No effect on liver enzymes  No effect on lipid profiles  No effect on renal function  Efficacy – Primary Endpoint Change in Hb1Ac for IN-105 not statistically significant due to higher than anticipated placebo effect X 29
  • 31. TOP LINE# & BOTTOM LINE# INR crore / USD mn FY08 FY09 FY10 FY11 Revenue 1,090 273 1,194 260 1,493 318 1,858 407 EBITDA 335 83 372 81 455 97 573 125 Net profit* 225 56 238 52 273 58 340 74 FY12 FY11 Revenue 2,148 | 445 1,858 | 407 EBIDTA 579 | 120 573 | 125 27% 31% PAT 338 | 70 340 | 74 16% 19% EPS 17.3 17.4 FY08-11: Avg.exch.rate in that fiscal ; FY12: USD 1 = INR 48.1; FY11: USD 1= INR 45.67 # 78% stake acquired in Axicorp GmBH in April ‘08.; fully divested as of March’11 . Hence all figures are ex-Axicorp. Figures for FY11 and FY12 in accordance with latest revisions in schedule VI. * Net profit is pre-exceptional in table 1.No exceptional items in FY10 and FY11. 31