1. GENERAL REACTIONS – overall pathway is exergonic
GLYCOLYSIS CITRIC ACID CYCLE & e-
TRANSPORT CHAIN
Where: Where:
cytoplasm mitochondrium
General: General
Does not use O2 Uses O2
Energy from substrate
Most ancient of pathways
Overall pathway: Overall pathway:
Glucose 2 pyruvate Pyruvate 6CO2 + 6H2O
net 2 ATP 36 ATP
2 NADH

2. Produces large amounts of ATP with O2 acting as e- acceptor.
Occurs in the Mtiochondrium
PYRUVATE 1. Acetyl CoEnzyme A
Coenzyme NAD+ EACH PYRUVATE GENERATES:
+H
1 NADH
CO2 NADH 1 CO2 (RELEASED)
ACETYL CoA CoA

3. 2. Citric acid cycle/
Krebs Cycle CoA
CITRATE
OXALOACETATE
3 NAD+
ATP
3 NADH
ADP +
P FAD
FADH2
2 CO2
EACH PYRUVATE GENERATES:
3 NADH 1 FADH2
1 ATP 2 CO2

4. 3. ALL COMPOUNDS AT THE END OF THE KREBS CYCLE – THIS
IS FOR TWO PYRUVATES
CO2 ATP NADH FADH2
GLYCOLYSIS 0 2 2 0
made directly
ACETYL Co-A 2 0 2 0
ACTIVATION
KREB CYCLE 4 2 6 2
Made directly

5. Fig. 6-11a
Space H
between
membranes H H H H H
Electron H H
H
carrier H H H H
Protein
complex
Inner
mitochondrial
membrane
FADH2 FAD
Electron H
flow
O2  2 H
1
2
H2O
NADH
NAD ADP  P ATP
H H H H
H
Matrix Electron transport chain ATP synthase

6. SPECIFICS
GENERATED ATP
per Glucose
(= 2 pyruvate)
1. GLYCOLYSIS 2 NADH 6 ATP
2 ATP (directly)
2. ACETYL CoA 2 NADH 6 ATP
3. KREBS 6 NADH 18 ATP
2 FADH2 4 ATP
2 ATP
3 ATP per NADH
2 ATP per FADH2