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The Role of Glutathione in Cell Defense, with References to Clinical Deficiencies and Treatment Thomas A. Kwyer, M.D.

Glutathione Precursors: Amino Acids ,[object Object],[object Object],[object Object],[object Object],[object Object]

Glutathione: L-glutamylcysteinylglycine ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

Immunonutrition in the Critically Ill: a Systematic Review of Clinical Outcomes (12 studies with 1,557 subjects, 1,482 of whom were analyzed) ,[object Object],[object Object],[object Object]

Immunonutrition in the Critically Ill: a Systematic Review of Clinical Outcomes (Summary) ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

Effect of Immune Enhancement on Length of Therapeutic Intervention in Severe Abdominal Trauma

Effect of Immune Enhancement on Total Hospitalization Cost in Severe Abdominal Trauma

Effect of Immune Enhancement on Total Hospital Days in Severe Abdominal Trauma

Pathogenesis of Glutathione Deficiency: Cytokine Selection (Slide 1) ,[object Object],[object Object],[object Object],[object Object]

Pathogenesis of Glutathione Deficiency: Cytokine Selection (Slide 2) ,[object Object],[object Object],[object Object]

“ Defective Antigen Processing Correlates with a Low Level of Intracellular Glutathione” ,[object Object],[object Object],[object Object],[object Object],[object Object]

“ Lymphocyte Proliferation in Glutathione-depleted Lymphocytes: Direct Relationship Between Glutathione Availability and the Proliferative Response” ,[object Object],[object Object],[object Object],[object Object]

Pathogenesis of Glutathione Deficiency in the Immune Response: Summary ,[object Object],[object Object],[object Object],[object Object],[object Object]

Pathogenesis of Glutathione Deficiency and Apoptosis: AIDS (Slide 1) ,[object Object],[object Object],[object Object],[object Object],[object Object]

Pathogenesis of Glutathione Deficiency and Apoptosis: AIDS (Slide 2) ,[object Object],[object Object],[object Object]

Pathogenesis of Glutathione Deficiency and Apoptosis: AIDS (Summary) ,[object Object],[object Object],[object Object],[object Object]

Benefits of Glutathione Enhancement in Disease or Stress: Pulmonary Disease ,[object Object],[object Object],[object Object]

Benefits of Glutathione Enhancement in Disease or Stress: Pulmonary Disease ,[object Object],[object Object],[object Object],[object Object],[object Object]

Method of Intracellular GSH Enhancement: Undenatured Whey Protein Concentration ,[object Object],[object Object],[object Object],[object Object]

Cystine: the Preferred Substrate for Optimal Glutathione Synthesis and Immune Enhancement ,[object Object],[object Object],[object Object]

Proton Donation is the Basis for Preservation of the Amino Acid Pool (Positive Nitrogen Balance) (Dröge, W, FASEB J., 1997 Nov.;11(13):1077-89)

Proton Donation: the Sulfur of Glutathione can give up a Proton (H + ) GSH + GSH  GSSG + 2H +

Pathogenesis of Cystine Deficiency: Wasting Syndromes (Slide 1) ,[object Object],[object Object],[object Object]

Pathogenesis of Cystine Deficiency: Wasting Syndromes (Slide 2) ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

Pathogenesis of Cystine Deficiency: Wasting Syndromes (Slide 3) ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

Pathogenesis of Cystine Deficiency: Wasting Syndromes (Slide 4) ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

Glutathione Precursor Transport: Cystine is Preferred form of Cysteine for GSH Synthesis ,[object Object],[object Object],[object Object]

Glutathione Depleting Agents Smoking. Alcohol. Caffeine. Acetaminophen. Drugs. Vigorous exercise. x-,  - and UV radiation Xenobiotics.

Total Parenteral Nutrition: the Road to Enteral Atrophy, Leaky Gut Syndrome and Pneumonitis ,[object Object],[object Object],[object Object],[object Object]

Total Parenteral Nutrition: the Road to Enteral Atrophy, Leaky Gut Syndrome and Pneumonitis ,[object Object],[object Object],[object Object],[object Object],[object Object]

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