The Wales Cancer Bank aims to establish a collection of tissue and blood samples from cancer patients in Wales to help identify novel biomarkers for cancer prediction, prognosis, and personalized treatment. It has consented over 3,190 patients from 7 hospitals since 2005. Patients have been actively involved as advisors, donors, and advocates. They provide a unique perspective and want to help advance cancer research that could benefit future patients. The biobank must responsibly use samples for high-quality reproducible research to further knowledge and develop new treatments.