6. Total 1.2 million microarrays available
Doubles every 2-3 years
Butte AJ. Translational Bioinformatics:
coming of age. JAMIA, 2008.
7.
8.
9. ~300 Diseases
and Conditions
20k+ Genes
Blue: gene goes down
in disease
Yellow: gene goes up
in disease
Human Disease
Gene Expression Collection
Butte AJ, Kohane IS. Nature Biotechnology, 2006, 24:55.
Butte AJ, Chen R. Proc AMIA Fall Symposium, 2006.
Chen R, Butte AJ. Nature Methods, 2007.
Dudley J, Tibshirani R, Deshpande T, Butte AJ. Molecular
Systems Biology, 2009.
Shen-Orr S, ... Davis MM, Butte AJ. Nature Methods, 2010.
Joel Dudley
10. Lamb J, ..., Golub TR. Science, 2006.
Sirota M, Dudley JT, ..., Sweet-Cordero A, Sage J, Butte AJ.
Science Translational Medicine, 2011.
Marina Sirota
Joel Dudley
11. Rat colonoscopy Rat with
Inflammatory
Bowel Disease
Inflammatory
Bowel Disease
After
Anti-seizure Drug
Dudley JT, Sirota M, ..., Pasricha J, Butte AJ. Science Translational Medicine, 2011.
Anti-seizure drug works against a rat model of
inflammatory bowel disease
24. Thanks
• Kristin Goldthorpe
• Michelle Christierson
• Priya Singh
• Michele Schiele and Ted Tussing
• Carlos Bustamante, Euan Ashley, Russ Altman,
Alan Yeung, Phil Lavori
• All our helpers and volunteers
• Phil Pizzo
• Lloyd Minor
• John Bell
• Li Ka Shing Foundation