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ISS National Laboratory Pathfinder Missions

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American Astronautical Society
American Astronautical Society

Jeanne L. Becker, PhD, 2010 American Astronautical Society Goddard Memorial Symposium

Technologie
1 von 15
ISS National Laboratory Pathfinder Missions Therapeutics for Infectious Disease Jeanne L. Becker, Ph.D.
Overview: Therapeutics for Infectious Disease ,[object Object],[object Object],[object Object],[object Object],[object Object]
[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
An experiment conducted on the space shuttle demonstrated that Salmonella grown in space becomes more virulent, as compared to the same bacteria grown here on earth
[object Object],[object Object],[object Object],[object Object],If the cause of the increased virulence could be determined, can this knowledge be used to create a vaccine?
[object Object],[object Object],[object Object],[object Object],[object Object]
[object Object],[object Object],[object Object]
[object Object],[object Object],[object Object],[object Object],[object Object]
Flight Studies ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],Taking advantage of the changes in biological processes that occur in microgravity to create new treatments for disease
[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
[object Object],[object Object],[object Object],[object Object],[object Object],Pathfinder Progress
How can using space change drug development on earth? ,[object Object],[object Object],[object Object],[object Object]
Using Space to Develop Products for Earth ,[object Object],[object Object],+ = Virulence Gene Deletion Flight testing IND
[object Object],[object Object],http:// www.youtube.com/watch?v =n57djMwDZAs

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ISS National Laboratory Pathfinder Missions

  • 1. ISS National Laboratory Pathfinder Missions Therapeutics for Infectious Disease Jeanne L. Becker, Ph.D.
  • 2.
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  • 5. An experiment conducted on the space shuttle demonstrated that Salmonella grown in space becomes more virulent, as compared to the same bacteria grown here on earth
  • 6.
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Hinweis der Redaktion

  1. The end point, or the effect is that microbes change in microgravity. The consequences surrounding this effect this may be associated with bacterial growth, its susceptibility to antibiotics, its pathogenicity or ability to cause disease, and its virulence or potency.
  2. For this work, our approach was to go to the published literature, and take advantage of the scientific evidence to point us towards the gene candidates for Salmonella enteritidis known to be associated with virulence, hence be a potential target for future vaccine development
  3. We knew C elegans would work well, since it has been flown before, and known to survive well in the environment of spaceflight, and the BioServe group has experience in flying the organism
  4. Heidemarie Stefanyshyn-Piper STS-126 November 20, 2008
  5. John Phillips STS-119 March 18, 2009
  6. John Phillips STS-119 March 18, 2009