Preventing blindness with damaged cells studies; and how the location and histone code influence in Epigenomics. Molecular biology folding.
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By Camilo Arias Rodríguez. Medical student. UPB.
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Preventing blindness with damaged cells studies; and how the location and histone code influence in Epigenomics. Molecular biology folding.
- 1. Preventing blindness with damaged cells studies; and how the location and histone code influence in Epigenomics. Camilo Arias Rodríguez Medical student.
- 4. Introduction Epigenetics: Non genetic factors influencing DNA structure. Eye as a focus of degenerative diseases, leading to blindness. Research as a way to understand, solve and improve.
- 5. Mohammad Haeri, Barry E. Knox, Aphrodite Ahmadi.Modeling the Flexural Rigidity of Rod Photoreceptors.Biophysical Journal, 2013; 104 (2): 300 DOI:
- 6. Average photoreceptor: -Cilyndrical shape. - Outer segment. - Discs. - Function: To convert light into chemical and electric signals.
- 7. Closer eye cell structure. Discs of the outer segment are vulnerable to damage and breakage (mutations). Because of rhodopsin high concentration.
- 8. High density bands High rhodopsin concentration Vulnerable to damage and Low density bands breakage. Average rhodopsin Degenerative diseases Flexible and concentration can lead easily to steady. blindness.
- 9. Student comment I think the mutation in the photoreceptors discs, can be used as a diagnosis help, to define how many risks does a patient have to turn blind.
- 10. Menzies Chen, Katherine Licon, Rei Otsuka, Lorraine Pillus, Trey Ideker. Decoupling Epigenetic and Genetic Effects through Systematic Analysis of Gene Position.Cell Reports, 2013; DOI: 10.1016/j.celrep.2012.12.003
- 11. - Histones are the basic component of the chromatin. - Both DNA and histones, define the landscape of certain genes.
- 12. Epigenetic Alteration Mix of histones Gene identity in genes material expresion.
- 13. - It was made a prove which consisted on inserting the gene in different locations of chromatine. - Experimental model: Yeast chromosome 1.
- 14. Student comment. I consider epigenomics help us to discover how can the environment affect some genes expression, and how can they produce a mutation, giving us tools to prevent those diseases
- 15. Medical utility Student comment. New theory We’ll be able to understand easier the causes of retinal and eye diseases in general, and their development.
- 16. Medical utility Student comment. New theory New treatments and cures based on the theory of the high concentration of rhodopsin in discs, will treat in a better way patients with eye diseases, evoiding getting blind.
- 17. Medical utility Student comment. New theory Tools to make more researches about genes.
- 18. Medical utility Student comment. New theory Will help us understanding how genes work, and to make a relation between their location and themselves, and how can diseases appear and work depending on their chromatin ‘environment’.
- 19. •· [Http://sciencedaily.com/releases/2013/01/130103130756.htm] Checked on January 29th of 2013, 22:50. “In Epigenomics, Location Is Everything: Researchers Exploit Gene Position to test: ‘Histone Code’” •· [http://sciencedaily.com/releases/2013/01/130122122403.htm] Checked on January 29th of 2013, 22:32. “Study of How Eye Cells Become Damaged Could Help Prevent Blindness:”
- 20. “Be determined, hug life and live with passion. Lose with class and win with courage. The World belongs to those who face no fear and life is too valuable to feel insignificant.”