6. Need Drugs?

7. Normal State

8. Monoamine theory (iproniazid, 1950-irreversible MAO I) [NE] low Depressive State

9. Biosynthesis of Neurotransmitters (acetylcholine and monoamines)

10. Projections of Norepinephrine Containing Neurons in the Locus Coeruleus

11. [NE] Treatment State (I)

12. [NE] Treatment State (II) *Increase [NE], [5-HT] or [DA]

13. Monoamine transporter NE

14. Serotonin (5-HT) Transporter Polymorphism Missense mutation Obsessive-compulsive disorder (Molecular Psychiatry 2003: 8, 933-936)

15. Autoreceptor Desensitization

17. 3 5 4 1 2 R S R N R D