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1.
Sickle cell anemia
Hemolytic anemia
2.
3.
4.
5.
Frontal Bossing X-ray:
‘Hair-on-end’ skull Chronic leg ulcer
6.
7.
8.
2. Hb electrophoresis
– Identification & quantification of HbS (80% Hbs, absence of HbA; HbF & HbA 2 variably increased)
9.
10.
11.
12.
An enlarged spleen
due to splenic sequestration crisis in a patient with sickle anemia
13.
Sickle cells are
seen in splenic red pulp in a case of splenic sequestration crisis.
14.
Kidney: Hemosidrin deposit
LIVER: HEMOSIDEROSIS Hemosiderin deposits
15.
Alloimmune/ Isoimmune: 1)
Hemolytic Transfusion Reaction 2) Hemolytic Disease of the Newborn Hemolytic anemia RBCs are lysed as a result of the action of antibodies of another individual
16.
17.
18.
Hemostatic disorders
19.
20.
21.
22.
23.
24.
25.
26.
27.
28.
29.
30.
31.
32.
33.
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