1. Intestinal Permeability/leaky gut

2. Disruption of cells lining the intestine leads to
intestinal hyperpermeability which has been
proposed by some researchers to involve a
relationship with acute and chronic diseases
such as systemic inflammatory response
syndrome (SIRS), inflammatory bowel
disease, diabetes, allergies, asthma, autism.

3. Can manifest in a variety of ways

4. Observations/ the evolution approach
• Cavemen (pre-agriculturalists) and modern hunter
gatherers did not suffer from the diseases of modern
civilization.
• The diets of hunter gather’s we free of grains, legumes and
dairy.
• Are genes are virtually identical to cavemen ( yeah but they
are also virtually identical to chimps)
• Grains , legumes and dairy are neolithic (new) foods.
Invalid inference: We should eat devoid of grains, legumes and
dairy.
Just an observation. But a good one.

5. Yes more questions need to be asked

6. For example: we can find new food
sources of food and adapt to it

7. Research/the anti-nutrient approach
• Have we adapted to the consumption of
grains
• Are these evolutionary novel foods a problem
with our biochemistry?
• Well Plants have anti-nutrients as a defense
mechanism. But it all depends on the digestive
process.

10. Saponins are antinutrients

11. We need to consider this!

12. Other antinutrients

15. They are everywhere!
Food is out to kill us!
No not really.
• Heat deactivates most of these antinutrients.
• Also have to consider what happens when you
consume these things as part of real foods.

17. Depends. If you don’t cook them well. yeah

18. Prolamines
Storage proteins. The above is gluten. Really tough
to digest. We see this when we try to ferment it.