27. Rules Acid drugs – become more NON ionized in acidic pH Basic drugs – become more NON ionized in basic pH (alkaline pH) Acid Drug Basic Drug Acid pH Environment Basic pH Environment
28. Rules Acid drugs – become more NON ionized in acidic pH Basic drugs – become more NON ionized in basic pH (alkaline pH) Acid Drug Basic Drug Acid pH Environment Basic pH Environment NON-ionized NON-ionized
29. Rules Acid drugs – become more NON ionized in acidic pH Basic drugs – become more NON ionized in basic pH (alkaline pH) Acid Drug Basic Drug Acid pH Environment Basic pH Environment NON-ionized NON-ionized IONIZED
30. Rules Acid drugs – become more NON ionized in acidic pH Basic drugs – become more NON ionized in basic pH (alkaline pH) Acid Drug Basic Drug Acid pH Environment Basic pH Environment NON-ionized NON-ionized IONIZED IONIZED
32. Depending if a molecule is ionized or not determines if it can pass through a cell membrane C E L L M E M B R A N E Ionized Molecule Non-Ionized Molecule
33.
34. Acid Drug = Non ionized molecules = Ionized molecules Acid drugs – become more NON ionized in acidic pH pH 2 N I pH 6 N I pH 9 I pH 8 I N
35. Basic Drug = Non ionized molecules = Ionized molecules Basic drugs – become more NON ionized in basic pH pH 9 N I pH 8 N I pH 2 I pH 6 I N