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Hypersensitivity
Introduction ,[object Object],[object Object],[object Object],[object Object],[object Object]
Type Ⅰ hypersensitivity ,[object Object],[object Object],[object Object],[object Object],[object Object]
Component and cells ,[object Object],[object Object],[object Object]
Reaginic antibody (IgE) ,[object Object],[object Object]
Mast cells ,[object Object],[object Object],[object Object]
IgE-binding Fc recepors ,[object Object],[object Object]
Mediators released by mast cells ,[object Object],[object Object]
Mechanism of typeⅠhypersensitivity ,[object Object],[object Object]
[object Object],[object Object]
The mechanism of typeⅠhypersensitivity
Typical diseases of anaphylaxis  ,[object Object],[object Object]
Atopy ,[object Object],[object Object],[object Object]
[object Object],[object Object]
 
Therapy of typeⅠhypersensitivity ,[object Object],[object Object],[object Object]
Atopic allergies and their treatment
[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],Type Ⅱ hypersensitivity
Mechanism of tissue damage of typeⅡ hypersensitivity
Type Ⅱ associated diseases ,[object Object],[object Object],[object Object]
Heamolytic diseases of newborn ,[object Object],[object Object],[object Object]
Hemolytic disease of the newborn due to rhesus incompatibility
Drug-induced hemolytic anemia ,[object Object]
Grave’s disease and myasthenia gravis ,[object Object],[object Object],[object Object]
Myasthenia gravis Grave’s disease
Type Ⅲ hypersensitivity ,[object Object],[object Object],[object Object]
Mechanism of type Ⅲ hypersensitivity
[object Object],[object Object],[object Object],[object Object]
Immune complex-mediated (type Ⅲ) hypersensitivity
Type Ⅲ associated diseases ,[object Object],[object Object],[object Object],[object Object]
[object Object],[object Object],[object Object],Type Ⅲ associated diseases
Type Ⅳ hypersensitivity ,[object Object],[object Object],[object Object],[object Object]
Immune pathogenesis ,[object Object]
 
[object Object],[object Object],[object Object],[object Object],[object Object],Type Ⅳ associated diseases
Summary ,[object Object],[object Object],[object Object],[object Object]
 
 
Summary ,[object Object],[object Object],[object Object],[object Object]
Thanks!
Clustering of IgE receptors
Patholo-gical changes in asthma
An atopic eczema reaction
ADCC mediated by NK
The ABO system Phenotype  genotype Ag on RBC (agglutinins) Ab to ABO in serum (isohem-agglutinins) A AA, AO A Anti-B B BB, BO B Anti-A AB AB A and B none O OO H Anti-A and anti-B
Histology of acute inflammatory reaction in type Ⅲ hypersensitivity
IgE mediated mast cell activation and degranulation
Skin reaction of atopic allergy (Skin prick tests)
Deposition of immune complex in the kidney glomerulus
Vasculitic skin rashes due to immune complex deposition
Granuloma in tuberculosis infection
 

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