Prof Riaz Ahmed

Prof. Muhammad Riaz Bhatti MBBS(K.E.), DPM., RCP&RCS(Dublin), MCCEE (Canada) FRSH(Lond), MRCPsych,(Lond) FRCPsych.,(Lond) ,[object Object],[object Object],[object Object]

Evolving Role of Benzodiazepines in the Treatment of Anxiety

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Anxiety & Hypertension ,[object Object],[object Object],[object Object],[object Object],[object Object]

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Evolving Role of Benzodiazepines in Anxiety Disorders ,[object Object],[object Object],[object Object],[object Object]

Anxiety Disorders DSM=Diagnostic and Statistical Manual; GAD=generalized anxiety disorder; OCD=obsessive-compulsive disorder; PTSD=posttraumatic stress disorder. Social anxiety disorder Panic disorder OCD GAD PTSD DMS-IV Spectrum of Anxiety Disorders

Currently Available Interventions for Anxiety Disorders ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

Evolution in the Treatment of Anxiety Disorders Benzodiazepines (Buspirone) TCAs SSRIs & SNRIs CBT Combos CBT=cognitive-behavioral therapy; SSRIs=selective serotonin reuptake inhibitors; SNRIs=serotonin and norepinephrine reuptake inhibitors; TCAs=tricyclic antidepressants.

Drug Use in Generalized Anxiety Disorder (Percent of Total Rxs) NDTI MAT August 2001.

Drug Use in Panic Disorder (Percent of Total Rxs) BZD=benzodiazepine; Rxs=prescriptions. NDTI MAT August 2001. Total BZD=42%

Pharmacotherapy received by Panic Disorder patients in the HARP study (1989-2001) SE Bruce et al, poster presented at the 22 nd ADAA meeting, March 2002

Current Diagnostic Trends ,[object Object],[object Object],[object Object]

Current Treatment Options ,[object Object],[object Object]

Sites of Action - Benzodiazepines ,[object Object],Fear Stahl SM. J Clin Psychiatry 63:9, 2002

SSRIs for Anxiety Disorders: Disadvantages ,[object Object],[object Object],[object Object],[object Object],[object Object]

Benzodiazepines for Anxiety Disorders: Advantages ,[object Object],[object Object],[object Object],[object Object],[object Object],Ballenger et al. J Clin Psychiatry. 1998;59(suppl 9):51. Furukawa et al. J Affect Disord. 2001;65:173. Goddard et al. Arch Gen Psychiatry. 2001;58:681. .

Benzodiazepines for Anxiety Disorders: Disadvantages ,[object Object],[object Object],[object Object],Ninan. J Clin Psychiatry. 1999;60(suppl 22). Petursson and Lader. Br J Addict. 1981;76:133.

Is Long-term Benzodiazepine Treatment Justified? ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],DuPont and DuPont. Clinical Textbook of Addictive Disorders. 1998.

Combining Antidepressants with Benzodiazepines ,[object Object],[object Object],[object Object],[object Object]

Patient History ,[object Object],[object Object],[object Object],[object Object]

Patient History (cont.) ,[object Object],[object Object],[object Object],[object Object],[object Object]

Management Questions ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

Conclusions ,[object Object],[object Object]

Prof Riaz Ahmed

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Prof Riaz Ahmed