Only a few years ago the epidemic of heartworm disease was primarily located in the southern parts of the United States.

1. Tri-Heart Plus for Dogs to Prevent Parasites and Heartworm Infection
PRODUCT INFO
Tri-heart plus is a microfilaricide monthly, oral preventative medication used in dogs to prevent parasites.
WHAT THIS PRODUCT CURES
Tri-heart Plus is formulated to kill the immature heartworm
(Dirofilaria immitis) and is also used to treat/control
hookworm (Ancylostoma caninum, A. brasiliense,
and Uncinaria stenocephala) infestations.
For product details click at http://www.allvetmed.com/TriHeart-Plus-p/TRIHPK61.htm
PET SYMPTOMS
The early stages of the heartworm (Dirofilaria immitis) and
the hookworm (Ancylostoma caninum, A. brasiliense,
and Uncinaria stenocephala) do not permit symptoms in
dogs. It is not until the parasites have thrived within the pet
will symptoms be noted. The heartworm is transmitted into
a dog through the mosquito bite. As the mosquito takes his blood meal, he injects the larvae stage heartworm into
the dermal layer of the dog’s body. Once the heartworm has matured into mature larvae he will travel into the
blood stream of the dog until he reaches the heart.
After several years definite signs will develop as the parasite reproduces, invading the heart and lungs. A dog will
develop a cough due to worms beginning to crowd the lungs. This cough could be very mild or severe. Your pet
may also appear to be tired or worn out. You would notice these symptoms quickly in a high spirited pet. Loss of
appetite and weight loss are also common signs your pet could be infested with heartworms as well as jaundice
and fever. Jaundice, or a yellowing of the mucus membranes, occurs when the liver is failing. These signs are more
serious and are reaching the stage of no return.
Hookworms are potentially dangerous to cats, dogs, rodents, and humans. In other words hookworm disease is
Zoonotic, meaning a disease of animals that is transmitted to humans. The hookworm that takes host to canines is
called Ancylostoma caninum. This hookworm can penetrate the human skin causing a condition called cutaneous
larval migrants, more commonly called creeping eruption or ground itch in lament terms. The life cycle of the
hookworms begins like many others, as eggs. These eggs pass through fecal matter of infected mammals and
under warm conditions, hatch into larva within approximately one to two days. These larvae thrive in the fecal
matter and soil for about a week, where they then proceed to molt two more times.

2. The hookworm searches for a host at the stage three life cycles. The hookworm will hook onto the skin of a host,
penetrating the skin deep. Once inside the host, they are carried through the blood vessels to the heart and then
into the lungs. The worms now begin to move quickly, piercing through the pulmonary alveoli, reaching the
bronchial tree to the pharynx (lung and throat region) and the host swallows them. The larva then move toward
the intestines where they will mature, reproduce, and thrive. A pet infected with hookworms will display severe
diarrhea, bloody diarrhea, become weak, develop a poor hair coat, and lose weight.
Pet Aliment
Only a few years ago the epidemic of heartworm disease was primarily located in the southern parts of the United
States. Over the years, heartworm disease has spread all over the world as the migration of mosquitoes (the vector
of heartworm filarial) enters into new locations of the world. Pet owners should take heartworm disease as well as
hookworm infestations very seriously as pet aliments include; sudden collapse, harsh cough, drowsiness, diarrhea,
and sudden death.
PETS WITH ALIMENTS
Pale mucus membrane due to
hookworm infestation.
Removed heart filled with heartworms
after dog's sudden death.
RELATIVE INFO ON BREED MOST ASSOCIATED WITH THIS AILMENT
Heartworm disease and hookworms affects all dogs and cats around the world. There is only one breed of heart
worm; Dirofilaria immitis and two breeds of hookworms; Ancylostoma caninum, A. brasiliense, and Uncinaria
stenocephala.
QUESTIONS FOR MY VET
My dog weighs less than 10lbs but the package says give to dogs of 25 pounds. So I administer the whole pill?
a.) Yes. Entire tablet should be taken but break up the pill for easy swallow.
®
Can Tri-Heart Plus tablets be given to pregnant females?
a.) Active ingredients; Ivermectin/pyrantel are extremely safe ingredients. These ingredients make the product safe
enough to be used in pregnant, lactating females, and puppies 6 weeks old.

3. I accidentally administered two tablets of the product in one day, will my dog be alright?
a.)Contact your veterinarian immediately if accidental overdose occurs. A good rule of thumb when it comes to
treating your pet is to have a calendar of the day you administered product.
My dog is currently taking other medications; will this product interact with medication?
A.) flea collars, dips, shampoos, anthelmintics (deworming medications), antibiotics, vaccines, and steroid have all
been tested as safe to take with this product. On specific medications consult your veterinarian.
I realized my dog has not had his dose from last month administered. Could there be a chance he is no longer
protected?
Doses which are more than 30days apart decrees protective effect of product. Consult your veterinarian to have a
heartworm test taken to insure your pet is not infected. Administer dose once you remember.
Where could I purchase Tri-Heart Plus tablets?
a.) This product is available only by veterinary prescription and can be purchased at your local veterinary clinic.
How safe is this product safe?
a.) Tri-heart Plus tablets are FDA approved as safe when administered according to enclosed directions.
One of the tablets within my package of Tri-heart plus came out of its blister pocket. Is this pill still good?
A.) Each tablet is placed within a foil blister pocket to shield said tablet from light and moisture. A pill which has
come in contact with either element should not be administered to your pet.
I have a cat which also needs a heartworm preventative; can I use a smaller dose of my dog’s medication?
a.) No. The active ingredients in this product are hazardous to cats and should never be given to felines.
1. Is this product still effective to administer after the expiration date?
®
a.) Tri-Heart Plus, should never be administered after the expiration date.
How it Works
Tri-heart Plus is a combination medicine containing both ivermectin and pyrantel pamoate. Ivermectin interferes
with the parasite’s transmition of nerves leading to paralysis and termination of heartworms. Pyrantel Pamoate
interferes with the parasite’s transmition of nerves leading to paralysis and termination of hookworms.
Heartworm
Microfilaria in the
bloodstream of a
dog.
Tri-heart Plus
tablet given with
food to terminate
microfloria.
Clean blood
sample after
treatment.

4. DIRECTIONS FOR USE:
Dogs:
1.
2.
3.
4.
Product is to be given orally and meant to be chewed.
Medication can be given alongside food.
Break down large pills to ease digestion in small dogs.
Administer pills once a month.
Pet owners; prevent overdose to your pet by scheduling the date to administer. Place a reminder or check off list
to ensure dosage on appropriate day.
DOSAGE AND ADMINISTRATION:
Administer once monthly for prevention of heartworms and hookworms. Product is to be given according to
weight. Pills available for small, medium, and large dogs.
Ingredients
Active ingredients
ivermectin
Pyrantel pamoate.
Product Cautions
1.
2.
3.
Do not use this product in cats.
Not intended for use in puppies under 6 weeks of age.
Safe for all herding dog breeds, pregnant, and lactating females.
Storage: Store away from sunlight and moisture. Store at room temperature.
BRAND VS GENERIC COMPARISON
Two generic equivalencies of Tri-heart plus are available for use in dogs. Iverhart Plus ad Heartgard Plus contain
the same active ingredients as Tri-heart Plus and vary in price. These two generic forms are proven just as effective
as Tri-heart when stored appropriately. Generic forms of medications not purchased from a veterinarian may have
come into contact with sunlight, decreasing effectiveness.